The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development View Full Text


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Article Info

DATE

2004-05

AUTHORS

Heather J Hinton, Dario R Alessi, Doreen A Cantrell

ABSTRACT

T lymphocyte activation is associated with activation of diverse AGC serine kinases (named after family members protein kinase A, protein kinase G and protein kinase C). It has been difficult to assess the function of these molecules in T cell development with simple gene-deletion strategies because different isoforms of AGC kinases are coexpressed in the thymus and have overlapping, redundant functions. To circumvent these problems, we explored the consequences of genetic manipulation of phosphoinositide-dependent kinase 1 (PDK1), a rate-limiting 'upstream' activator of AGC kinases. Here we analyzed the effect of PDK1 deletion on T lineage development. We also assessed the consequences of reducing PDK1 levels to 10% of normal. Complete PDK1 loss blocked T cell differentiation in the thymus, whereas reduced PDK1 expression allowed T cell differentiation but blocked proliferative expansion. These studies show that AGC family kinases are essential for T cell development. More... »

PAGES

539-545

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1062

DOI

http://dx.doi.org/10.1038/ni1062

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010176249

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15077109


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N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni1062'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ni1062'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni1062'


 

This table displays all metadata directly associated to this object as RDF triples.

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