Persistent Toll-like receptor signals are required for reversal of regulatory T cell–mediated CD8 tolerance View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-05

AUTHORS

Yiping Yang, Ching-Tai Huang, Xiaopei Huang, Drew M Pardoll

ABSTRACT

One chief barrier to cancer immunotherapy is tumor-specific T cell tolerance. Here we compared the ability of hemagglutinin (HA)-encoding recombinant viruses versus 'HA-loaded' dendritic cells to reverse HA-specific CD8 tolerance and to protect mice from tumor challenge. Both vaccines were comparable in activating naive HA-specific CD8(+) T cells. However, in circumstances of established tolerance, viral vaccines could break CD8 tolerance in the presence of CD4(+)CD25(+) regulatory T cells, whereas dendritic cell-based vaccines achieved this only after removal of regulatory T cells or the coadministration of a Toll-like receptor (TLR) ligand or irrelevant virus. These results demonstrate that virus provides TLR signals required for bypassing regulatory T cell-mediated tolerance and emphasize the importance of persistent TLR signals for immunotherapy in the setting of established tolerance. More... »

PAGES

508-515

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1059

DOI

http://dx.doi.org/10.1038/ni1059

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036107081

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15064759


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