Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-04

AUTHORS

Pietro G Andres, Kimberly C Howland, Ajay Nirula, Lawrence P Kane, Luke Barron, Douglas Dresnek, Ali Sadra, John Imboden, Arthur Weiss, Abul K Abbas

ABSTRACT

CD28 costimulation is essential for CD4(+) T cell proliferation, survival, interleukin 2 (IL-2) production and T helper type 2 development. To define the nature of the signals that may drive different T cell responses, we have done a structure-function analysis of the CD28 cytoplasmic tail in primary T cells. CD28-mediated T cell proliferation and IL-2 production did not require a particular cytoplasmic domain. In contrast, IL-4 production was driven by the cooperative activity of specific motifs within the CD28 cytoplasmic tail. Using a gene-complementation approach, we provide evidence that one component of this T helper type 2 differentiation signal was mediated by 3-phosphoinositide-dependent protein kinase 1. Thus, different mechanisms underlie the induction of distinct T cell functional responses by CD28. More... »

PAGES

435-442

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1044

DOI

http://dx.doi.org/10.1038/ni1044

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043075527

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15004555


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