Regulatory T cells mediate maternal tolerance to the fetus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-03

AUTHORS

Varuna R Aluvihare, Marinos Kallikourdis, Alexander G Betz

ABSTRACT

Pregnancy constitutes a major challenge to the maternal immune system, as it has to tolerate the persistence of paternal alloantigen. Although localized mechanisms contribute to fetal evasion from immune attack, maternal alloreactive lymphocytes persist. We demonstrate here an alloantigen-independent, systemic expansion of the maternal CD25+ T cell pool during pregnancy and show that this population contains dominant regulatory T cell activity. In addition to their function in suppressing autoimmune responses, maternal regulatory T cells suppressed an aggressive allogeneic response directed against the fetus. Their absence led to a failure of gestation due to immunological rejection of the fetus. More... »

PAGES

266-271

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1037

DOI

http://dx.doi.org/10.1038/ni1037

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024409300

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14758358


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