An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-01

AUTHORS

Gérard Eberl, Shana Marmon, Mary-Jean Sunshine, Paul D Rennert, Yongwon Choi, Dan R Littman

ABSTRACT

Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes and Peyer's patches. We show here that during fetal life the nuclear hormone receptor RORgamma(t) is expressed exclusively in and is required for the generation of LTi cells. RORgamma(t+) LTi cells provide essential factors, among which lymphotoxin-alpha1beta2 is necessary but not sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues. More... »

PAGES

64-73

Journal

TITLE

Nature Immunology

ISSUE

1

VOLUME

5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1022

DOI

http://dx.doi.org/10.1038/ni1022

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049866186

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14691482


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryonic and Fetal Development", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Green Fluorescent Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intercellular Adhesion Molecule-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Luminescent Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoid Tissue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphotoxin-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Receptor Subfamily 1, Group F, Member 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Interleukin-7", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Retinoic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Thyroid Hormone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes, Helper-Inducer", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Cell Adhesion Molecule-1", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eberl", 
        "givenName": "G\u00e9rard", 
        "id": "sg:person.01220406175.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220406175.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marmon", 
        "givenName": "Shana", 
        "id": "sg:person.01243253361.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243253361.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.", 
            "Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sunshine", 
        "givenName": "Mary-Jean", 
        "id": "sg:person.01333263770.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333263770.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biogen (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417832.b", 
          "name": [
            "Department of Immunology, Biogen, Cambridge, Massachusetts 02142, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rennert", 
        "givenName": "Paul D", 
        "id": "sg:person.01336670561.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336670561.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Yongwon", 
        "id": "sg:person.010624305154.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010624305154.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.", 
            "Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Littman", 
        "givenName": "Dan R", 
        "id": "sg:person.01120551745.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120551745.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1084/jem.20011885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000490084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/ir:25:3:219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001076751", 
          "https://doi.org/10.1385/ir:25:3:219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/11.5.643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003805470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005801952", 
          "https://doi.org/10.1038/ni903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005801952", 
          "https://doi.org/10.1038/ni903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-1119(96)00504-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006097134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(02)00339-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007200634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1997.4980", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008255158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.17.1.399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010944975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.189.2.403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012696781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80588-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015336876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017023674", 
          "https://doi.org/10.1038/nri1054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017023674", 
          "https://doi.org/10.1038/nri1054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1521-4141(199912)29:12<4072::aid-immu4072>3.0.co;2-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018241115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.18.10132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019683640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.193.5.621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020872761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80371-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022179174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/10.1.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022928209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830240224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023549183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(02)00395-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025110476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(02)00423-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026712898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(02)00479-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027059773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81798-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028129628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1062677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028561095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/9.4.507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029378306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830271020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030982668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35018581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031928930", 
          "https://doi.org/10.1038/35018581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35018581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031928930", 
          "https://doi.org/10.1038/35018581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.189.7.1025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033424235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80589-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034133442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038075405", 
          "https://doi.org/10.1038/ni791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038075405", 
          "https://doi.org/10.1038/ni791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.184.5.1999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039553480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20021294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040335750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-065x.2003.00074.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043143119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.192.10.1467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043455245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20030169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044168662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.20.11019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044470757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81511-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044913244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/17812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045754219", 
          "https://doi.org/10.1038/17812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/17812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045754219", 
          "https://doi.org/10.1038/17812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(90)90214-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046578655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.184.1.259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046837865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-065x.2002.18905.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051275210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80645-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051729079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.288.5475.2369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062570082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8171322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062653000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083238723", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-01", 
    "datePublishedReg": "2004-01-01", 
    "description": "Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes and Peyer's patches. We show here that during fetal life the nuclear hormone receptor RORgamma(t) is expressed exclusively in and is required for the generation of LTi cells. RORgamma(t+) LTi cells provide essential factors, among which lymphotoxin-alpha1beta2 is necessary but not sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ni1022", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1022778", 
        "issn": [
          "1529-2908", 
          "1529-2916"
        ], 
        "name": "Nature Immunology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "An essential function for the nuclear receptor ROR\u03b3t in the generation of fetal lymphoid tissue inducer cells", 
    "pagination": "64-73", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ed8bb48db6e495988bd131e2e166b52abc14c4f33eedcb7c6f67a7b20f424f94"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14691482"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100941354"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ni1022"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049866186"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ni1022", 
      "https://app.dimensions.ai/details/publication/pub.1049866186"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87097_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/ni1022"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ni1022'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni1022'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ni1022'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni1022'


 

This table displays all metadata directly associated to this object as RDF triples.

331 TRIPLES      21 PREDICATES      92 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ni1022 schema:about N1dab7c93ef484de7a33aff385367d3da
2 N4038a295444349a590f646ff094f3790
3 N49cb53982dda49dabc6c4ea23202cf0c
4 N52c7937c9b3d45e8973633ec729f993a
5 N5c4802377ef347cba3d08cafadf1966c
6 N600c24ce8eb449b2a7bd2dfa10ed4bda
7 N60c4e3693bb9489e8c58dbbbddda4f9f
8 N77c38b02889b49b59d97f90d1dfcf0f5
9 N7fc168d557704d548879f9e0a371bea3
10 Nad3f280914354c88aa3f39858da8409b
11 Nad5da506a8a14113bb0cb24126de5ecf
12 Nb5e19a938e0943d288d5e33fe06df30a
13 Nb906e7857b8b4b6bbd03739d593adb01
14 Nd3273b6986dd4857841e155b67760579
15 Nd6d75b6497f7460890cf5ca5e4edc578
16 Ndb3f49d7cf93461e86aba3ef931666a6
17 Ne3ea832a49f44b8894606c9b6a18f053
18 Ne6b2da2babd744769e0ec00816461e93
19 Nf3103dc865be4bc7b7722b889eadd25f
20 Nf91ae52d54004472925a6fff7987f41d
21 anzsrc-for:06
22 anzsrc-for:0601
23 schema:author Nfe60a6e3e95f43d58cc3573cd06da891
24 schema:citation sg:pub.10.1038/17812
25 sg:pub.10.1038/35018581
26 sg:pub.10.1038/ni791
27 sg:pub.10.1038/ni903
28 sg:pub.10.1038/nri1054
29 sg:pub.10.1385/ir:25:3:219
30 https://app.dimensions.ai/details/publication/pub.1083238723
31 https://doi.org/10.1002/(sici)1521-4141(199912)29:12<4072::aid-immu4072>3.0.co;2-e
32 https://doi.org/10.1002/eji.1830240224
33 https://doi.org/10.1002/eji.1830271020
34 https://doi.org/10.1006/geno.1997.4980
35 https://doi.org/10.1016/0092-8674(90)90214-y
36 https://doi.org/10.1016/s0092-8674(00)81511-1
37 https://doi.org/10.1016/s0092-8674(00)81798-5
38 https://doi.org/10.1016/s0378-1119(96)00504-5
39 https://doi.org/10.1016/s1074-7613(00)80371-4
40 https://doi.org/10.1016/s1074-7613(00)80588-9
41 https://doi.org/10.1016/s1074-7613(00)80589-0
42 https://doi.org/10.1016/s1074-7613(00)80645-7
43 https://doi.org/10.1016/s1074-7613(02)00339-4
44 https://doi.org/10.1016/s1074-7613(02)00395-3
45 https://doi.org/10.1016/s1074-7613(02)00423-5
46 https://doi.org/10.1016/s1074-7613(02)00479-x
47 https://doi.org/10.1034/j.1600-065x.2002.18905.x
48 https://doi.org/10.1034/j.1600-065x.2003.00074.x
49 https://doi.org/10.1073/pnas.93.20.11019
50 https://doi.org/10.1073/pnas.97.18.10132
51 https://doi.org/10.1084/jem.184.1.259
52 https://doi.org/10.1084/jem.184.5.1999
53 https://doi.org/10.1084/jem.189.2.403
54 https://doi.org/10.1084/jem.189.7.1025
55 https://doi.org/10.1084/jem.192.10.1467
56 https://doi.org/10.1084/jem.193.5.621
57 https://doi.org/10.1084/jem.20011885
58 https://doi.org/10.1084/jem.20021294
59 https://doi.org/10.1084/jem.20030169
60 https://doi.org/10.1093/intimm/10.1.1
61 https://doi.org/10.1093/intimm/11.5.643
62 https://doi.org/10.1093/intimm/9.4.507
63 https://doi.org/10.1126/science.1062677
64 https://doi.org/10.1126/science.288.5475.2369
65 https://doi.org/10.1126/science.8171322
66 https://doi.org/10.1146/annurev.immunol.17.1.399
67 schema:datePublished 2004-01
68 schema:datePublishedReg 2004-01-01
69 schema:description Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes and Peyer's patches. We show here that during fetal life the nuclear hormone receptor RORgamma(t) is expressed exclusively in and is required for the generation of LTi cells. RORgamma(t+) LTi cells provide essential factors, among which lymphotoxin-alpha1beta2 is necessary but not sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues.
70 schema:genre research_article
71 schema:inLanguage en
72 schema:isAccessibleForFree false
73 schema:isPartOf Na88ca0add85f4d88a99dd6b9fd1085d0
74 Ne659766f8ed84957885781b61f9674f4
75 sg:journal.1022778
76 schema:name An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells
77 schema:pagination 64-73
78 schema:productId N0ce6a22867d34f46a531a0c8985268cb
79 N419511b0d2534d7c9ea6a5386fadc17b
80 N440fc36f7b124229a2b057d3928ba6ca
81 Nd7e1af6636d441d3a15e4d53e43daea1
82 Nf133c8f9b3b84422a358592c450da21b
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049866186
84 https://doi.org/10.1038/ni1022
85 schema:sdDatePublished 2019-04-11T12:24
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher N6ca494501fda4841bc8f4effbc93a609
88 schema:url http://www.nature.com/articles/ni1022
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N0ce6a22867d34f46a531a0c8985268cb schema:name nlm_unique_id
93 schema:value 100941354
94 rdf:type schema:PropertyValue
95 N1dab7c93ef484de7a33aff385367d3da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Female
97 rdf:type schema:DefinedTerm
98 N28579d422f574b38bb2c2331d71266bc rdf:first sg:person.01243253361.07
99 rdf:rest Nca5946d8cf5f4c94bff013c15a9bbafc
100 N30022ec7ed104a428bb2944ad4ace53f rdf:first sg:person.01120551745.00
101 rdf:rest rdf:nil
102 N4038a295444349a590f646ff094f3790 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Embryonic and Fetal Development
104 rdf:type schema:DefinedTerm
105 N419511b0d2534d7c9ea6a5386fadc17b schema:name pubmed_id
106 schema:value 14691482
107 rdf:type schema:PropertyValue
108 N440fc36f7b124229a2b057d3928ba6ca schema:name dimensions_id
109 schema:value pub.1049866186
110 rdf:type schema:PropertyValue
111 N49cb53982dda49dabc6c4ea23202cf0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Luminescent Proteins
113 rdf:type schema:DefinedTerm
114 N4a3cb623423e48319cffab53aff3185f rdf:first sg:person.010624305154.23
115 rdf:rest N30022ec7ed104a428bb2944ad4ace53f
116 N52c7937c9b3d45e8973633ec729f993a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Immunohistochemistry
118 rdf:type schema:DefinedTerm
119 N5c4802377ef347cba3d08cafadf1966c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Intercellular Adhesion Molecule-1
121 rdf:type schema:DefinedTerm
122 N600c24ce8eb449b2a7bd2dfa10ed4bda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Mice
124 rdf:type schema:DefinedTerm
125 N60c4e3693bb9489e8c58dbbbddda4f9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Lymphotoxin-alpha
127 rdf:type schema:DefinedTerm
128 N6520e5f37e9647cab300222072eba736 schema:name Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.
129 rdf:type schema:Organization
130 N6ca494501fda4841bc8f4effbc93a609 schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 N7302a99ddf8a49f19122e7241148079d schema:name Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.
133 Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.
134 rdf:type schema:Organization
135 N77c38b02889b49b59d97f90d1dfcf0f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Lymphoid Tissue
137 rdf:type schema:DefinedTerm
138 N7e0c206e46e442649f61514fd6e75a9d rdf:first sg:person.01336670561.54
139 rdf:rest N4a3cb623423e48319cffab53aff3185f
140 N7fc168d557704d548879f9e0a371bea3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Organogenesis
142 rdf:type schema:DefinedTerm
143 N828bedc0b56e43da921d461a26f97e33 schema:name Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.
144 rdf:type schema:Organization
145 Na88ca0add85f4d88a99dd6b9fd1085d0 schema:issueNumber 1
146 rdf:type schema:PublicationIssue
147 Nad3f280914354c88aa3f39858da8409b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Green Fluorescent Proteins
149 rdf:type schema:DefinedTerm
150 Nad5da506a8a14113bb0cb24126de5ecf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Receptors, Thyroid Hormone
152 rdf:type schema:DefinedTerm
153 Nb5e19a938e0943d288d5e33fe06df30a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Vascular Cell Adhesion Molecule-1
155 rdf:type schema:DefinedTerm
156 Nb906e7857b8b4b6bbd03739d593adb01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Flow Cytometry
158 rdf:type schema:DefinedTerm
159 Nca5946d8cf5f4c94bff013c15a9bbafc rdf:first sg:person.01333263770.18
160 rdf:rest N7e0c206e46e442649f61514fd6e75a9d
161 Nd3273b6986dd4857841e155b67760579 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Animals
163 rdf:type schema:DefinedTerm
164 Nd6d75b6497f7460890cf5ca5e4edc578 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Receptors, Retinoic Acid
166 rdf:type schema:DefinedTerm
167 Nd7e1af6636d441d3a15e4d53e43daea1 schema:name doi
168 schema:value 10.1038/ni1022
169 rdf:type schema:PropertyValue
170 Ndb3f49d7cf93461e86aba3ef931666a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name T-Lymphocytes, Helper-Inducer
172 rdf:type schema:DefinedTerm
173 Ne3ea832a49f44b8894606c9b6a18f053 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Mice, Knockout
175 rdf:type schema:DefinedTerm
176 Ne659766f8ed84957885781b61f9674f4 schema:volumeNumber 5
177 rdf:type schema:PublicationVolume
178 Ne6b2da2babd744769e0ec00816461e93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Receptors, Interleukin-7
180 rdf:type schema:DefinedTerm
181 Nf133c8f9b3b84422a358592c450da21b schema:name readcube_id
182 schema:value ed8bb48db6e495988bd131e2e166b52abc14c4f33eedcb7c6f67a7b20f424f94
183 rdf:type schema:PropertyValue
184 Nf3103dc865be4bc7b7722b889eadd25f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Nuclear Receptor Subfamily 1, Group F, Member 3
186 rdf:type schema:DefinedTerm
187 Nf91ae52d54004472925a6fff7987f41d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Male
189 rdf:type schema:DefinedTerm
190 Nf9647466c20c4bbdb8f80a5ff34ecd13 schema:name Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.
191 Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.
192 rdf:type schema:Organization
193 Nfe60a6e3e95f43d58cc3573cd06da891 rdf:first sg:person.01220406175.50
194 rdf:rest N28579d422f574b38bb2c2331d71266bc
195 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
196 schema:name Biological Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
199 schema:name Biochemistry and Cell Biology
200 rdf:type schema:DefinedTerm
201 sg:journal.1022778 schema:issn 1529-2908
202 1529-2916
203 schema:name Nature Immunology
204 rdf:type schema:Periodical
205 sg:person.010624305154.23 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
206 schema:familyName Choi
207 schema:givenName Yongwon
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010624305154.23
209 rdf:type schema:Person
210 sg:person.01120551745.00 schema:affiliation N7302a99ddf8a49f19122e7241148079d
211 schema:familyName Littman
212 schema:givenName Dan R
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120551745.00
214 rdf:type schema:Person
215 sg:person.01220406175.50 schema:affiliation N828bedc0b56e43da921d461a26f97e33
216 schema:familyName Eberl
217 schema:givenName Gérard
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220406175.50
219 rdf:type schema:Person
220 sg:person.01243253361.07 schema:affiliation N6520e5f37e9647cab300222072eba736
221 schema:familyName Marmon
222 schema:givenName Shana
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243253361.07
224 rdf:type schema:Person
225 sg:person.01333263770.18 schema:affiliation Nf9647466c20c4bbdb8f80a5ff34ecd13
226 schema:familyName Sunshine
227 schema:givenName Mary-Jean
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333263770.18
229 rdf:type schema:Person
230 sg:person.01336670561.54 schema:affiliation https://www.grid.ac/institutes/grid.417832.b
231 schema:familyName Rennert
232 schema:givenName Paul D
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336670561.54
234 rdf:type schema:Person
235 sg:pub.10.1038/17812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045754219
236 https://doi.org/10.1038/17812
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/35018581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031928930
239 https://doi.org/10.1038/35018581
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/ni791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038075405
242 https://doi.org/10.1038/ni791
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/ni903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005801952
245 https://doi.org/10.1038/ni903
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/nri1054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017023674
248 https://doi.org/10.1038/nri1054
249 rdf:type schema:CreativeWork
250 sg:pub.10.1385/ir:25:3:219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001076751
251 https://doi.org/10.1385/ir:25:3:219
252 rdf:type schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1083238723 schema:CreativeWork
254 https://doi.org/10.1002/(sici)1521-4141(199912)29:12<4072::aid-immu4072>3.0.co;2-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1018241115
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/eji.1830240224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023549183
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1002/eji.1830271020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030982668
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1006/geno.1997.4980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008255158
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/0092-8674(90)90214-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1046578655
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/s0092-8674(00)81511-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044913244
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/s0092-8674(00)81798-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028129628
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s0378-1119(96)00504-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006097134
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/s1074-7613(00)80371-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022179174
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s1074-7613(00)80588-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015336876
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s1074-7613(00)80589-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034133442
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s1074-7613(00)80645-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051729079
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s1074-7613(02)00339-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007200634
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s1074-7613(02)00395-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025110476
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/s1074-7613(02)00423-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026712898
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s1074-7613(02)00479-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027059773
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1034/j.1600-065x.2002.18905.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051275210
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1034/j.1600-065x.2003.00074.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043143119
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1073/pnas.93.20.11019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044470757
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1073/pnas.97.18.10132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019683640
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1084/jem.184.1.259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046837865
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1084/jem.184.5.1999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039553480
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1084/jem.189.2.403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012696781
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1084/jem.189.7.1025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033424235
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1084/jem.192.10.1467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043455245
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1084/jem.193.5.621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020872761
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1084/jem.20011885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000490084
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1084/jem.20021294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040335750
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1084/jem.20030169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044168662
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1093/intimm/10.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022928209
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1093/intimm/11.5.643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003805470
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1093/intimm/9.4.507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029378306
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1126/science.1062677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028561095
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1126/science.288.5475.2369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062570082
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1126/science.8171322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653000
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1146/annurev.immunol.17.1.399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010944975
325 rdf:type schema:CreativeWork
326 https://www.grid.ac/institutes/grid.25879.31 schema:alternateName University of Pennsylvania
327 schema:name Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.417832.b schema:alternateName Biogen (United States)
330 schema:name Department of Immunology, Biogen, Cambridge, Massachusetts 02142, USA.
331 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...