CTLA-4: new insights into its biological function and use in tumor immunotherapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-07

AUTHORS

Jackson G Egen, Michael S Kuhns, James P Allison

ABSTRACT

The discovery of multiple costimulatory cell surface molecules that influence the course of T cell activation has increased our appreciation of the complexity of the T cell response. It remains clear, however, that CD28 and cytotoxic T lymphocyte antigen 4 (CTLA-4) are the critical costimulatory receptors that determine the early outcome of stimulation through the T cell antigen receptor (TCR). Details of how the T cell integrates TCR stimulation with the costimulatory signals of CD28 and the inhibitory signals of CTLA-4 remain to be established, but unique features of the cell biology of CTLA-4 provide important insights into its function. We summarize here recent findings that suggest a previously unrecognized role for CTLA-4 in the regulation of T cell responses. We also describe preclinical and clinical results that indicate manipulation of CTLA-4 has considerable promise as a strategy for the immunotherapy of cancer. More... »

PAGES

611-618

References to SciGraph publications

  • 2002-02. Secretory lysosomes in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2001-12. T-cell regulation by CD28 and CTLA-4 in NATURE REVIEWS IMMUNOLOGY
  • 1987-07. A new member of the immunoglobulin superfamily—CTLA-4 in NATURE
  • 2002-05. Structural mechanisms of costimulation in NATURE IMMUNOLOGY
  • 2002-02. The B7–CD28 superfamily in NATURE REVIEWS IMMUNOLOGY
  • Journal

    TITLE

    Nature Immunology

    ISSUE

    7

    VOLUME

    3

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni0702-611

    DOI

    http://dx.doi.org/10.1038/ni0702-611

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024203574

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12087419


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