The role of PI3K in immune cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-04

AUTHORS

Shigeo Koyasu

ABSTRACT

Members of the phosphoinositide-3 kinase (PI3K) family control several cellular responses including cell growth, survival, cytoskeletal remodeling and the trafficking of intracellular organelles in many different types of cell. In particular PI3K has important functions in the immune system. It has been difficult to evaluate the roles of distinct PI3Ks in cellular immune responses because no PI3K inhibitors are specific for individual family members and because most stimuli activate several PI3K enzymes. The development of gene-targeted mice now enables us to examine the physiological functions of individual PI3K enzymes in the immune system in vivo. More... »

PAGES

313-319

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni0403-313

    DOI

    http://dx.doi.org/10.1038/ni0403-313

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001831695

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12660731


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