The molecular basis of TCR germline bias for MHC is surprisingly simple View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02

AUTHORS

K Christopher Garcia, Jarrett J Adams, Dan Feng, Lauren K Ely

ABSTRACT

The elusive etiology of germline bias of the T cell receptor (TCR) for major histocompatibility complex (MHC) has been clarified by recent 'proof-of-concept' structural results demonstrating the conservation of specific TCR-MHC interfacial contacts in complexes bearing common variable segments and MHC allotypes. We suggest that each TCR variable-region gene product engages each type of MHC through a 'menu' of structurally coded recognition motifs that have arisen through coevolution. The requirement for MHC-restricted T cell recognition during thymic selection and peripheral surveillance has necessitated the existence of such a coded recognition system. Given these findings, a reconsideration of the TCR-peptide-MHC structural database shows that not only have the answers been there all along but also they were predictable by the first principles of physical chemistry. More... »

PAGES

143-147

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.f.219

    DOI

    http://dx.doi.org/10.1038/ni.f.219

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016211641

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19148199


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