THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02-27

AUTHORS

Seeyoung Choi, Claude Warzecha, Ekaterina Zvezdova, Jan Lee, Jérémy Argenty, Renaud Lesourne, L Aravind, Paul E Love

ABSTRACT

THEMIS, a T cell-specific protein with high expression in CD4+CD8+ thymocytes, has a crucial role in positive selection and T cell development. THEMIS lacks defined catalytic domains but contains two tandem repeats of a distinctive module of unknown function (CABIT). Here we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1. This action was mediated by the CABIT modules, which bound to the phosphatase domain of SHP-1 and promoted or stabilized oxidation of SHP-1's catalytic cysteine residue, which inhibited the tyrosine-phosphatase activity of SHP-1. Deletion of SHP-1 alleviated the developmental block in Themis-/- thymocytes. Thus, THEMIS facilitates thymocyte positive selection by enhancing the T cell antigen receptor signaling response to low-affinity ligands. More... »

PAGES

433-441

References to SciGraph publications

  • 2010-03. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species in NATURE IMMUNOLOGY
  • 2014-09. In vivo functional mapping of the conserved protein domains within murine Themis1 in IMMUNOLOGY AND CELL BIOLOGY
  • 2003-03. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways in NATURE IMMUNOLOGY
  • 2004-08. T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation in NATURE IMMUNOLOGY
  • 2013-04. T cell receptor signalling networks: branched, diversified and bounded in NATURE REVIEWS IMMUNOLOGY
  • 2015-12. Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis in NATURE COMMUNICATIONS
  • 2013-12. Themis sets the signal threshold for positive and negative selection in T-cell development in NATURE
  • 2009-08. Themis controls thymocyte selection through regulation of T cell antigen receptor–mediated signaling in NATURE IMMUNOLOGY
  • 2014-09. The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function in NATURE IMMUNOLOGY
  • 2009-08. Themis, a T cell–specific protein important for late thymocyte development in NATURE IMMUNOLOGY
  • 2009-08. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection in NATURE IMMUNOLOGY
  • 2015-09. Trx1/TrxR1 system regulates post-selected DP thymocytes survival by modulating ASK1-JNK/p38 MAPK activities in IMMUNOLOGY AND CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.3692

    DOI

    http://dx.doi.org/10.1038/ni.3692

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084129196

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28250424


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Clonal Selection, Antigen-Mediated", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Deletion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intracellular Signaling Peptides and Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxidation-Reduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Binding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Interaction Domains and Motifs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Tyrosine Phosphatase, Non-Receptor Type 6", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reactive Oxygen Species", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Antigen, T-Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Thymocytes", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "National Institute of Child Health and Human Development", 
              "id": "https://www.grid.ac/institutes/grid.420089.7", 
              "name": [
                "Section on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Choi", 
            "givenName": "Seeyoung", 
            "id": "sg:person.01062520523.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062520523.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Child Health and Human Development", 
              "id": "https://www.grid.ac/institutes/grid.420089.7", 
              "name": [
                "Section on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Warzecha", 
            "givenName": "Claude", 
            "id": "sg:person.01170611744.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170611744.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Child Health and Human Development", 
              "id": "https://www.grid.ac/institutes/grid.420089.7", 
              "name": [
                "Section on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zvezdova", 
            "givenName": "Ekaterina", 
            "id": "sg:person.01107746605.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107746605.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Child Health and Human Development", 
              "id": "https://www.grid.ac/institutes/grid.420089.7", 
              "name": [
                "Section on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Jan", 
            "id": "sg:person.01116425535.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116425535.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Physiopathology Center of Toulouse-Purpan", 
              "id": "https://www.grid.ac/institutes/grid.462366.3", 
              "name": [
                "Centre de Physiopathologie de Toulouse Purpan, Toulouse, France.", 
                "Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1043, Centre National de la Recherche Scientifique, U5282, and Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Toulouse, France."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Argenty", 
            "givenName": "J\u00e9r\u00e9my", 
            "id": "sg:person.01176747123.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176747123.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Physiopathology Center of Toulouse-Purpan", 
              "id": "https://www.grid.ac/institutes/grid.462366.3", 
              "name": [
                "Centre de Physiopathologie de Toulouse Purpan, Toulouse, France.", 
                "Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1043, Centre National de la Recherche Scientifique, U5282, and Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Toulouse, France."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lesourne", 
            "givenName": "Renaud", 
            "id": "sg:person.01165542441.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165542441.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "United States National Library of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.280285.5", 
              "name": [
                "National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aravind", 
            "givenName": "L", 
            "id": "sg:person.01106662166.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106662166.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Child Health and Human Development", 
              "id": "https://www.grid.ac/institutes/grid.420089.7", 
              "name": [
                "Section on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Love", 
            "givenName": "Paul E", 
            "id": "sg:person.0601463310.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601463310.22"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2008.00760.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000806221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2008.00760.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000806221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001845429", 
              "https://doi.org/10.1038/ni895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001845429", 
              "https://doi.org/10.1038/ni895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80327-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003969747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0908593106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004017047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0905039107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005199304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1163/15685530152744617", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005932368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0089115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006339505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.21.120601.141107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007566154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009622882", 
              "https://doi.org/10.1038/ni.1769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009622882", 
              "https://doi.org/10.1038/ni.1769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0040566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010282611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms9859", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011115934", 
              "https://doi.org/10.1038/ncomms9859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.23.021704.115647", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011985211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0105-2896.2006.00343.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012051348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0105-2896.2006.00343.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012051348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2007.04.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012571366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/intimm/dxm070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013795329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(01)00227-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015309312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1843", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016629576", 
              "https://doi.org/10.1038/ni.1843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019615920", 
              "https://doi.org/10.1038/nri3403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024448954", 
              "https://doi.org/10.1038/ni.2938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.02.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024476398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00793-09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025552516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20010659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030015772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/icb.2015.36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030234541", 
              "https://doi.org/10.1038/icb.2015.36"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030963266", 
              "https://doi.org/10.1038/ni1096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030963266", 
              "https://doi.org/10.1038/ni1096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/hsz-2014-0312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031554097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.21.21.7117-7136.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031862751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1768", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033246139", 
              "https://doi.org/10.1038/ni.1768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1768", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033246139", 
              "https://doi.org/10.1038/ni.1768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/icb.2014.43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034052141", 
              "https://doi.org/10.1038/icb.2014.43"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039404543", 
              "https://doi.org/10.1038/ni.1766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039404543", 
              "https://doi.org/10.1038/ni.1766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-cellbio-092910-154008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040318167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1742-4658.2012.08626.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040418183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200424962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040936250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042044646", 
              "https://doi.org/10.1038/nature12718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.021908.132706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043621383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2015.01.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045996923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.272.2.843", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047720580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/embj.201387725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050178878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.272.38.23552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052184808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.188.10.1867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053407118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.aad1576", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053560816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi801973z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055209268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi801973z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055209268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/0264-6021:3470173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056714649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/ars.2010.3611", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059231416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.272.5265.1173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062553126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.167.6.3391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074877106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.179.10.6456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077511686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1200123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078582921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1203389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078698176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4103/2319-4170.128725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078926852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1995.tb00043.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082446271"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-02-27", 
        "datePublishedReg": "2017-02-27", 
        "description": "THEMIS, a T cell-specific protein with high expression in CD4+CD8+ thymocytes, has a crucial role in positive selection and T cell development. THEMIS lacks defined catalytic domains but contains two tandem repeats of a distinctive module of unknown function (CABIT). Here we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1. This action was mediated by the CABIT modules, which bound to the phosphatase domain of SHP-1 and promoted or stabilized oxidation of SHP-1's catalytic cysteine residue, which inhibited the tyrosine-phosphatase activity of SHP-1. Deletion of SHP-1 alleviated the developmental block in Themis-/- thymocytes. Thus, THEMIS facilitates thymocyte positive selection by enhancing the T cell antigen receptor signaling response to low-affinity ligands.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ni.3692", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2725546", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2718383", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1022778", 
            "issn": [
              "1529-2908", 
              "1529-2916"
            ], 
            "name": "Nature Immunology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "18"
          }
        ], 
        "name": "THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1", 
        "pagination": "433-441", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "9088a3beef1aecdef74559b82bcfd840029898d8a3088fcf0e582206dc39c119"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28250424"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100941354"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ni.3692"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1084129196"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ni.3692", 
          "https://app.dimensions.ai/details/publication/pub.1084129196"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:18", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000339_0000000339/records_109493_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/ni/journal/v18/n4/full/ni.3692.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ni.3692'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni.3692'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ni.3692'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni.3692'


     

    This table displays all metadata directly associated to this object as RDF triples.

    363 TRIPLES      21 PREDICATES      96 URIs      38 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ni.3692 schema:about N067a42fc214b447098f6643638e3d5a7
    2 N1b64a109f4514afd91d50ad7f34a2aef
    3 N2dcf78995df849499991b9b5a0c42480
    4 N4d47a0fa86534aecb3050fc8df190a7d
    5 N4d7e003fefa84bb589c4c233d40e59e6
    6 N58d14fead8904525bc5f1a05bc4f4e9d
    7 N5932f3f9f77340c7beed79ee59711440
    8 N5e52cae861fd4dc2915a8654fe931490
    9 N6447553dd4964df5a2463262bccb5a28
    10 N69c96f6fccd1435189ece69fe37422cc
    11 N7cbbda83969049d291a56dce84b924bd
    12 Nb3a7e841b1ba4686b9e0125b3c1ab2be
    13 Nc32ba869f6b64171819fea407016a43e
    14 Ncceb87355af34cc4aa78921d54f67961
    15 Ne0a6d1b58e9d4ba9af92411c6e1f8102
    16 Nf4c64b727d474edbb6d977aafa071cf3
    17 Nfe3cc54d888f4ec5b769ef44de2bb107
    18 Nfec195dbadc143e7930bef80c891c0ba
    19 anzsrc-for:06
    20 anzsrc-for:0601
    21 schema:author N1ea213eed02d4759b1ee4eabe570c914
    22 schema:citation sg:pub.10.1038/icb.2014.43
    23 sg:pub.10.1038/icb.2015.36
    24 sg:pub.10.1038/nature12718
    25 sg:pub.10.1038/ncomms9859
    26 sg:pub.10.1038/ni.1766
    27 sg:pub.10.1038/ni.1768
    28 sg:pub.10.1038/ni.1769
    29 sg:pub.10.1038/ni.1843
    30 sg:pub.10.1038/ni.2938
    31 sg:pub.10.1038/ni1096
    32 sg:pub.10.1038/ni895
    33 sg:pub.10.1038/nri3403
    34 https://doi.org/10.1002/eji.200424962
    35 https://doi.org/10.1002/j.1460-2075.1995.tb00043.x
    36 https://doi.org/10.1016/j.cell.2005.02.036
    37 https://doi.org/10.1016/j.coi.2015.01.020
    38 https://doi.org/10.1016/j.immuni.2007.04.016
    39 https://doi.org/10.1016/s1074-7613(00)80327-1
    40 https://doi.org/10.1016/s1074-7613(01)00227-8
    41 https://doi.org/10.1021/bi801973z
    42 https://doi.org/10.1042/0264-6021:3470173
    43 https://doi.org/10.1073/pnas.0905039107
    44 https://doi.org/10.1073/pnas.0908593106
    45 https://doi.org/10.1074/jbc.272.2.843
    46 https://doi.org/10.1074/jbc.272.38.23552
    47 https://doi.org/10.1084/jem.188.10.1867
    48 https://doi.org/10.1084/jem.20010659
    49 https://doi.org/10.1089/ars.2010.3611
    50 https://doi.org/10.1093/intimm/dxm070
    51 https://doi.org/10.1111/j.0105-2896.2006.00343.x
    52 https://doi.org/10.1111/j.1600-065x.2008.00760.x
    53 https://doi.org/10.1111/j.1742-4658.2012.08626.x
    54 https://doi.org/10.1126/science.272.5265.1173
    55 https://doi.org/10.1126/scisignal.aad1576
    56 https://doi.org/10.1128/mcb.00793-09
    57 https://doi.org/10.1128/mcb.21.21.7117-7136.2001
    58 https://doi.org/10.1146/annurev-cellbio-092910-154008
    59 https://doi.org/10.1146/annurev.immunol.021908.132706
    60 https://doi.org/10.1146/annurev.immunol.21.120601.141107
    61 https://doi.org/10.1146/annurev.immunol.23.021704.115647
    62 https://doi.org/10.1163/15685530152744617
    63 https://doi.org/10.1371/journal.pone.0040566
    64 https://doi.org/10.1371/journal.pone.0089115
    65 https://doi.org/10.1515/hsz-2014-0312
    66 https://doi.org/10.15252/embj.201387725
    67 https://doi.org/10.4049/jimmunol.1200123
    68 https://doi.org/10.4049/jimmunol.1203389
    69 https://doi.org/10.4049/jimmunol.167.6.3391
    70 https://doi.org/10.4049/jimmunol.179.10.6456
    71 https://doi.org/10.4103/2319-4170.128725
    72 schema:datePublished 2017-02-27
    73 schema:datePublishedReg 2017-02-27
    74 schema:description THEMIS, a T cell-specific protein with high expression in CD4<sup>+</sup>CD8<sup>+</sup> thymocytes, has a crucial role in positive selection and T cell development. THEMIS lacks defined catalytic domains but contains two tandem repeats of a distinctive module of unknown function (CABIT). Here we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1. This action was mediated by the CABIT modules, which bound to the phosphatase domain of SHP-1 and promoted or stabilized oxidation of SHP-1's catalytic cysteine residue, which inhibited the tyrosine-phosphatase activity of SHP-1. Deletion of SHP-1 alleviated the developmental block in Themis<sup>-/-</sup> thymocytes. Thus, THEMIS facilitates thymocyte positive selection by enhancing the T cell antigen receptor signaling response to low-affinity ligands.
    75 schema:genre research_article
    76 schema:inLanguage en
    77 schema:isAccessibleForFree false
    78 schema:isPartOf N2e431f6060664754bb9fa1bbf2cff6e3
    79 N746fc35b67e046f191b244dff503851f
    80 sg:journal.1022778
    81 schema:name THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1
    82 schema:pagination 433-441
    83 schema:productId N1009bd7becce4b04816bfe9d924b82d7
    84 N23a041f91e714ad0acdcf17576dd6a7c
    85 N3428a937de074a2a9b61ef655110f713
    86 N994b1b8d50904b5a9c84013ab9dc628e
    87 Nbe54225c8a0b49408d22d21732fbb74b
    88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129196
    89 https://doi.org/10.1038/ni.3692
    90 schema:sdDatePublished 2019-04-11T09:18
    91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    92 schema:sdPublisher Nc92a08ba16df407cbc9cea253070e2d3
    93 schema:url http://www.nature.com/ni/journal/v18/n4/full/ni.3692.html
    94 sgo:license sg:explorer/license/
    95 sgo:sdDataset articles
    96 rdf:type schema:ScholarlyArticle
    97 N067a42fc214b447098f6643638e3d5a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Animals
    99 rdf:type schema:DefinedTerm
    100 N0a7dbee2c3124d99be91fe9d32abd64e rdf:first sg:person.01106662166.38
    101 rdf:rest Nf2e6534c6d0f433fb62ec477a95a9291
    102 N1009bd7becce4b04816bfe9d924b82d7 schema:name nlm_unique_id
    103 schema:value 100941354
    104 rdf:type schema:PropertyValue
    105 N1b64a109f4514afd91d50ad7f34a2aef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Gene Deletion
    107 rdf:type schema:DefinedTerm
    108 N1ea213eed02d4759b1ee4eabe570c914 rdf:first sg:person.01062520523.99
    109 rdf:rest Nbd052edd7042410396cd774d50082c73
    110 N23a041f91e714ad0acdcf17576dd6a7c schema:name readcube_id
    111 schema:value 9088a3beef1aecdef74559b82bcfd840029898d8a3088fcf0e582206dc39c119
    112 rdf:type schema:PropertyValue
    113 N2dcf78995df849499991b9b5a0c42480 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Cell Line
    115 rdf:type schema:DefinedTerm
    116 N2e431f6060664754bb9fa1bbf2cff6e3 schema:volumeNumber 18
    117 rdf:type schema:PublicationVolume
    118 N2f35245bd8214c829f495d5d3566534a rdf:first sg:person.01107746605.77
    119 rdf:rest N4f5f0f3fc82d443d80df82ff4fbdf825
    120 N3428a937de074a2a9b61ef655110f713 schema:name doi
    121 schema:value 10.1038/ni.3692
    122 rdf:type schema:PropertyValue
    123 N493a9f276d17420ba077455171b91b88 rdf:first sg:person.01176747123.55
    124 rdf:rest Nf13f4c7c5e12423590f1e383c889a194
    125 N4d47a0fa86534aecb3050fc8df190a7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Reactive Oxygen Species
    127 rdf:type schema:DefinedTerm
    128 N4d7e003fefa84bb589c4c233d40e59e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Thymocytes
    130 rdf:type schema:DefinedTerm
    131 N4f5f0f3fc82d443d80df82ff4fbdf825 rdf:first sg:person.01116425535.87
    132 rdf:rest N493a9f276d17420ba077455171b91b88
    133 N58d14fead8904525bc5f1a05bc4f4e9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Receptors, Antigen, T-Cell
    135 rdf:type schema:DefinedTerm
    136 N5932f3f9f77340c7beed79ee59711440 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Signal Transduction
    138 rdf:type schema:DefinedTerm
    139 N5e52cae861fd4dc2915a8654fe931490 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name T-Lymphocytes
    141 rdf:type schema:DefinedTerm
    142 N6447553dd4964df5a2463262bccb5a28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Protein Binding
    144 rdf:type schema:DefinedTerm
    145 N69c96f6fccd1435189ece69fe37422cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Mice
    147 rdf:type schema:DefinedTerm
    148 N746fc35b67e046f191b244dff503851f schema:issueNumber 4
    149 rdf:type schema:PublicationIssue
    150 N7cbbda83969049d291a56dce84b924bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Protein Tyrosine Phosphatase, Non-Receptor Type 6
    152 rdf:type schema:DefinedTerm
    153 N994b1b8d50904b5a9c84013ab9dc628e schema:name pubmed_id
    154 schema:value 28250424
    155 rdf:type schema:PropertyValue
    156 Nb3a7e841b1ba4686b9e0125b3c1ab2be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Protein Interaction Domains and Motifs
    158 rdf:type schema:DefinedTerm
    159 Nbd052edd7042410396cd774d50082c73 rdf:first sg:person.01170611744.19
    160 rdf:rest N2f35245bd8214c829f495d5d3566534a
    161 Nbe54225c8a0b49408d22d21732fbb74b schema:name dimensions_id
    162 schema:value pub.1084129196
    163 rdf:type schema:PropertyValue
    164 Nc32ba869f6b64171819fea407016a43e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Cell Differentiation
    166 rdf:type schema:DefinedTerm
    167 Nc92a08ba16df407cbc9cea253070e2d3 schema:name Springer Nature - SN SciGraph project
    168 rdf:type schema:Organization
    169 Ncceb87355af34cc4aa78921d54f67961 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Intracellular Signaling Peptides and Proteins
    171 rdf:type schema:DefinedTerm
    172 Ne0a6d1b58e9d4ba9af92411c6e1f8102 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Clonal Selection, Antigen-Mediated
    174 rdf:type schema:DefinedTerm
    175 Nf13f4c7c5e12423590f1e383c889a194 rdf:first sg:person.01165542441.67
    176 rdf:rest N0a7dbee2c3124d99be91fe9d32abd64e
    177 Nf2e6534c6d0f433fb62ec477a95a9291 rdf:first sg:person.0601463310.22
    178 rdf:rest rdf:nil
    179 Nf4c64b727d474edbb6d977aafa071cf3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Mice, Knockout
    181 rdf:type schema:DefinedTerm
    182 Nfe3cc54d888f4ec5b769ef44de2bb107 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Humans
    184 rdf:type schema:DefinedTerm
    185 Nfec195dbadc143e7930bef80c891c0ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Oxidation-Reduction
    187 rdf:type schema:DefinedTerm
    188 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    189 schema:name Biological Sciences
    190 rdf:type schema:DefinedTerm
    191 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    192 schema:name Biochemistry and Cell Biology
    193 rdf:type schema:DefinedTerm
    194 sg:grant.2718383 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.3692
    195 rdf:type schema:MonetaryGrant
    196 sg:grant.2725546 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.3692
    197 rdf:type schema:MonetaryGrant
    198 sg:journal.1022778 schema:issn 1529-2908
    199 1529-2916
    200 schema:name Nature Immunology
    201 rdf:type schema:Periodical
    202 sg:person.01062520523.99 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
    203 schema:familyName Choi
    204 schema:givenName Seeyoung
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062520523.99
    206 rdf:type schema:Person
    207 sg:person.01106662166.38 schema:affiliation https://www.grid.ac/institutes/grid.280285.5
    208 schema:familyName Aravind
    209 schema:givenName L
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106662166.38
    211 rdf:type schema:Person
    212 sg:person.01107746605.77 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
    213 schema:familyName Zvezdova
    214 schema:givenName Ekaterina
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107746605.77
    216 rdf:type schema:Person
    217 sg:person.01116425535.87 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
    218 schema:familyName Lee
    219 schema:givenName Jan
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116425535.87
    221 rdf:type schema:Person
    222 sg:person.01165542441.67 schema:affiliation https://www.grid.ac/institutes/grid.462366.3
    223 schema:familyName Lesourne
    224 schema:givenName Renaud
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165542441.67
    226 rdf:type schema:Person
    227 sg:person.01170611744.19 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
    228 schema:familyName Warzecha
    229 schema:givenName Claude
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170611744.19
    231 rdf:type schema:Person
    232 sg:person.01176747123.55 schema:affiliation https://www.grid.ac/institutes/grid.462366.3
    233 schema:familyName Argenty
    234 schema:givenName Jérémy
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176747123.55
    236 rdf:type schema:Person
    237 sg:person.0601463310.22 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
    238 schema:familyName Love
    239 schema:givenName Paul E
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601463310.22
    241 rdf:type schema:Person
    242 sg:pub.10.1038/icb.2014.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034052141
    243 https://doi.org/10.1038/icb.2014.43
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/icb.2015.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030234541
    246 https://doi.org/10.1038/icb.2015.36
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nature12718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042044646
    249 https://doi.org/10.1038/nature12718
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/ncomms9859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011115934
    252 https://doi.org/10.1038/ncomms9859
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/ni.1766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039404543
    255 https://doi.org/10.1038/ni.1766
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/ni.1768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033246139
    258 https://doi.org/10.1038/ni.1768
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/ni.1769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009622882
    261 https://doi.org/10.1038/ni.1769
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/ni.1843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016629576
    264 https://doi.org/10.1038/ni.1843
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/ni.2938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024448954
    267 https://doi.org/10.1038/ni.2938
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/ni1096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030963266
    270 https://doi.org/10.1038/ni1096
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/ni895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001845429
    273 https://doi.org/10.1038/ni895
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nri3403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019615920
    276 https://doi.org/10.1038/nri3403
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1002/eji.200424962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040936250
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1002/j.1460-2075.1995.tb00043.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082446271
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.cell.2005.02.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024476398
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.coi.2015.01.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045996923
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.immuni.2007.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012571366
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/s1074-7613(00)80327-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003969747
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/s1074-7613(01)00227-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015309312
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1021/bi801973z schema:sameAs https://app.dimensions.ai/details/publication/pub.1055209268
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1042/0264-6021:3470173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056714649
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1073/pnas.0905039107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005199304
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1073/pnas.0908593106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004017047
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1074/jbc.272.2.843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047720580
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1074/jbc.272.38.23552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052184808
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1084/jem.188.10.1867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053407118
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1084/jem.20010659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030015772
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1089/ars.2010.3611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059231416
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1093/intimm/dxm070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013795329
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1111/j.0105-2896.2006.00343.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012051348
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1111/j.1600-065x.2008.00760.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000806221
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1111/j.1742-4658.2012.08626.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040418183
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1126/science.272.5265.1173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062553126
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1126/scisignal.aad1576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053560816
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1128/mcb.00793-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025552516
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1128/mcb.21.21.7117-7136.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031862751
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1146/annurev-cellbio-092910-154008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040318167
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1146/annurev.immunol.021908.132706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043621383
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1146/annurev.immunol.21.120601.141107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007566154
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1146/annurev.immunol.23.021704.115647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011985211
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1163/15685530152744617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005932368
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1371/journal.pone.0040566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010282611
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1371/journal.pone.0089115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006339505
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1515/hsz-2014-0312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031554097
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.15252/embj.201387725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050178878
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.4049/jimmunol.1200123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078582921
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.4049/jimmunol.1203389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078698176
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.4049/jimmunol.167.6.3391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074877106
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.4049/jimmunol.179.10.6456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077511686
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.4103/2319-4170.128725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078926852
    353 rdf:type schema:CreativeWork
    354 https://www.grid.ac/institutes/grid.280285.5 schema:alternateName United States National Library of Medicine
    355 schema:name National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
    356 rdf:type schema:Organization
    357 https://www.grid.ac/institutes/grid.420089.7 schema:alternateName National Institute of Child Health and Human Development
    358 schema:name Section on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
    359 rdf:type schema:Organization
    360 https://www.grid.ac/institutes/grid.462366.3 schema:alternateName Physiopathology Center of Toulouse-Purpan
    361 schema:name Centre de Physiopathologie de Toulouse Purpan, Toulouse, France.
    362 Institut National de la Santé et de la Recherche Médicale, U1043, Centre National de la Recherche Scientifique, U5282, and Université de Toulouse, Université Paul Sabatier, Toulouse, France.
    363 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...