Gsk3 is a metabolic checkpoint regulator in B cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-01-23

AUTHORS

Julia Jellusova, Matthew H Cato, John R Apgar, Parham Ramezani-Rad, Charlotte R Leung, Cindi Chen, Adam D Richardson, Elaine M Conner, Robert J Benschop, James R Woodgett, Robert C Rickert

ABSTRACT

Mature B cells remain in a quiescent state until activated. Rickert and colleagues identify a prominent role for the kinase Gsk3 in resting naive B cells and in activated germinal center B cells that restrains the production of Myc and reactive oxygen species and prevents metabolic collapse.

PAGES

303-312

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni.3664

DOI

http://dx.doi.org/10.1038/ni.3664

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1074213041

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28114292


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