Acidic chitinase primes the protective immune response to gastrointestinal nematodes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05

AUTHORS

Kevin M Vannella, Thirumalai R Ramalingam, Kevin M Hart, Rafael de Queiroz Prado, Joshua Sciurba, Luke Barron, Lee A Borthwick, Allen D Smith, Margaret Mentink-Kane, Sandra White, Robert W Thompson, Allen W Cheever, Kevin Bock, Ian Moore, Lori J Fitz, Joseph F Urban, Thomas A Wynn

ABSTRACT

Acidic mammalian chitinase (AMCase) is known to be induced by allergens and helminths, yet its role in immunity is unclear. Using AMCase-deficient mice, we show that AMCase deficiency reduced the number of group 2 innate lymphoid cells during allergen challenge but was not required for establishment of type 2 inflammation in the lung in response to allergens or helminths. In contrast, AMCase-deficient mice showed a profound defect in type 2 immunity following infection with the chitin-containing gastrointestinal nematodes Nippostrongylus brasiliensis and Heligmosomoides polygyrus bakeri. The impaired immunity was associated with reduced mucus production and decreased intestinal expression of the signature type 2 response genes Il13, Chil3, Retnlb, and Clca1. CD103(+) dendritic cells, which regulate T cell homing, were also reduced in mesenteric lymph nodes of infected AMCase-deficient mice. Thus, AMCase functions as a critical initiator of protective type 2 responses to intestinal nematodes but is largely dispensable for allergic responses in the lung. More... »

PAGES

538-544

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni.3417

DOI

http://dx.doi.org/10.1038/ni.3417

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011889560

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27043413


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