Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-04

AUTHORS

Shih-Chin Cheng, Brendon P Scicluna, Rob J W Arts, Mark S Gresnigt, Ekta Lachmandas, Evangelos J Giamarellos-Bourboulis, Matthijs Kox, Ganesh R Manjeri, Jori A L Wagenaars, Olaf L Cremer, Jenneke Leentjens, Anne J van der Meer, Frank L van de Veerdonk, Marc J Bonten, Marcus J Schultz, Peter H G M Willems, Peter Pickkers, Leo A B Joosten, Tom van der Poll, Mihai G Netea

ABSTRACT

The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages in some patients, immunoparalysis may be encountered, which is associated with a poor outcome. By transcriptional and metabolic profiling of human patients with sepsis, we found that a shift from oxidative phosphorylation to aerobic glycolysis was an important component of initial activation of host defense. Blocking metabolic pathways with metformin diminished cytokine production and increased mortality in systemic fungal infection in mice. In contrast, in leukocytes rendered tolerant by exposure to lipopolysaccharide or after isolation from patients with sepsis and immunoparalysis, a generalized metabolic defect at the level of both glycolysis and oxidative metabolism was apparent, which was restored after recovery of the patients. Finally, the immunometabolic defects in humans were partially restored by therapy with recombinant interferon-γ, which suggested that metabolic processes might represent a therapeutic target in sepsis. More... »

PAGES

406-413

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni.3398

DOI

http://dx.doi.org/10.1038/ni.3398

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043334409

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26950237


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine Triphosphate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antifungal Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aspergillosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Candidiasis, Invasive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endotoxemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Energy Metabolism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Escherichia coli Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycolysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immune Tolerance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunity, Innate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoblotting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-gamma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lactic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipopolysaccharides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Monocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NAD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxygen Consumption", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sepsis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcriptome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "Shih-Chin", 
        "id": "sg:person.01233444754.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233444754.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center of Experimental & Molecular Medicine, Division of Infectious Diseases, Amsterdam Medical Center, University of Amsterdam, Amsterdam, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scicluna", 
        "givenName": "Brendon P", 
        "id": "sg:person.01141407025.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141407025.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arts", 
        "givenName": "Rob J W", 
        "id": "sg:person.014610477307.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014610477307.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gresnigt", 
        "givenName": "Mark S", 
        "id": "sg:person.01257242266.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257242266.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lachmandas", 
        "givenName": "Ekta", 
        "id": "sg:person.01074074465.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074074465.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giamarellos-Bourboulis", 
        "givenName": "Evangelos J", 
        "id": "sg:person.01116645416.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116645416.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Intensive Care and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kox", 
        "givenName": "Matthijs", 
        "id": "sg:person.01117674501.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117674501.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands.", 
            "Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manjeri", 
        "givenName": "Ganesh R", 
        "id": "sg:person.01114466025.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114466025.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud Institute for Molecular Life Sciences", 
          "id": "https://www.grid.ac/institutes/grid.461760.2", 
          "name": [
            "Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wagenaars", 
        "givenName": "Jori A L", 
        "id": "sg:person.01047711423.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047711423.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Utrecht", 
          "id": "https://www.grid.ac/institutes/grid.7692.a", 
          "name": [
            "Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cremer", 
        "givenName": "Olaf L", 
        "id": "sg:person.01035404167.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035404167.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.", 
            "Department of Intensive Care and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leentjens", 
        "givenName": "Jenneke", 
        "id": "sg:person.0751251524.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751251524.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center of Experimental & Molecular Medicine, Division of Infectious Diseases, Amsterdam Medical Center, University of Amsterdam, Amsterdam, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "van der Meer", 
        "givenName": "Anne J", 
        "id": "sg:person.01200544270.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200544270.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "van de Veerdonk", 
        "givenName": "Frank L", 
        "id": "sg:person.01311216724.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311216724.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Utrecht", 
          "id": "https://www.grid.ac/institutes/grid.7692.a", 
          "name": [
            "Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.", 
            "Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonten", 
        "givenName": "Marc J", 
        "id": "sg:person.010710050004.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010710050004.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Intensive Care Medicine Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schultz", 
        "givenName": "Marcus J", 
        "id": "sg:person.01007146366.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007146366.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud Institute for Molecular Life Sciences", 
          "id": "https://www.grid.ac/institutes/grid.461760.2", 
          "name": [
            "Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Willems", 
        "givenName": "Peter H G M", 
        "id": "sg:person.010154322272.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010154322272.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Intensive Care and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pickkers", 
        "givenName": "Peter", 
        "id": "sg:person.0622036530.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622036530.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joosten", 
        "givenName": "Leo A B", 
        "id": "sg:person.014645240657.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014645240657.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center of Experimental & Molecular Medicine, Division of Infectious Diseases, Amsterdam Medical Center, University of Amsterdam, Amsterdam, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "van der Poll", 
        "givenName": "Tom", 
        "id": "sg:person.01065476534.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065476534.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Netea", 
        "givenName": "Mihai G", 
        "id": "sg:person.01263677437.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263677437.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ccm.2008.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000936972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prca.200800016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001124221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prca.200800016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001124221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkr984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002391987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbabio.2008.04.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003420803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btg405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003878496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0901698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005113830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(02)09459-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006354524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gki624", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006993826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007525476", 
          "https://doi.org/10.1038/nri3901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000295593.25106.c4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008497320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0030161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009683731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010326831", 
          "https://doi.org/10.1038/nature03985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010326831", 
          "https://doi.org/10.1038/nature03985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010326831", 
          "https://doi.org/10.1038/nature03985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0914005107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011637541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/19.2.185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011853799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cytogfr.2014.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012497093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.1001759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013540250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2334-14-166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014226015", 
          "https://doi.org/10.1186/1471-2334-14-166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/biostatistics/kxj037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016217055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0079051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016567898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.3205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017102595", 
          "https://doi.org/10.1038/ni.3205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2004-5-10-r80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018457673", 
          "https://doi.org/10.1186/gb-2004-5-10-r80"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e3182923712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019418606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e3182923712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019418606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08830185.2014.969421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021028383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1100/2011/397971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022014723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms2343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024567785", 
          "https://doi.org/10.1038/ncomms2343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms1667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025863486", 
          "https://doi.org/10.1038/ncomms1667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0697-678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026465919", 
          "https://doi.org/10.1038/nm0697-678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2009.08.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027313040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkp427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027845966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkp427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027845966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2013-0015oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032002151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circheartfailure.112.000177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032123194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circheartfailure.112.000177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032123194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1208623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032706237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0000000000000949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032886629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0000000000000949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032886629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034144948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1251086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035224090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/1744666x.2014.943192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035934150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2015.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037365100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201003-0326oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038668601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2014.00680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038906616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198510000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039110630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198510000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039110630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/icb.2013.37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040202826", 
          "https://doi.org/10.1038/icb.2013.37"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201204-0645oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040357028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2006.05.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040848247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1478-811x-10-41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041070938", 
          "https://doi.org/10.1186/1478-811x-10-41"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btm311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042939614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btn647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043301996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2013.08.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045055863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1250684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045685233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mmbr.69.1.79-100.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045767507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10059-013-0169-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046946266", 
          "https://doi.org/10.1007/s10059-013-0169-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000321365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049453821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201307-1376oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049847752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11986", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051643661", 
          "https://doi.org/10.1038/nature11986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.362343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053354635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr801006e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056294743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/187152010793498663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069218346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7164/antibiotics.28.721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073629937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1302375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078850405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1402077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079053280"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-04", 
    "datePublishedReg": "2016-04-01", 
    "description": "The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages in some patients, immunoparalysis may be encountered, which is associated with a poor outcome. By transcriptional and metabolic profiling of human patients with sepsis, we found that a shift from oxidative phosphorylation to aerobic glycolysis was an important component of initial activation of host defense. Blocking metabolic pathways with metformin diminished cytokine production and increased mortality in systemic fungal infection in mice. In contrast, in leukocytes rendered tolerant by exposure to lipopolysaccharide or after isolation from patients with sepsis and immunoparalysis, a generalized metabolic defect at the level of both glycolysis and oxidative metabolism was apparent, which was restored after recovery of the patients. Finally, the immunometabolic defects in humans were partially restored by therapy with recombinant interferon-\u03b3, which suggested that metabolic processes might represent a therapeutic target in sepsis. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ni.3398", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3797303", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1022778", 
        "issn": [
          "1529-2908", 
          "1529-2916"
        ], 
        "name": "Nature Immunology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis", 
    "pagination": "406-413", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ce6b293750d67e5494db47e032d479460d4537c9dacfdfac64f139fa17a52661"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26950237"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100941354"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ni.3398"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043334409"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ni.3398", 
      "https://app.dimensions.ai/details/publication/pub.1043334409"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000467.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ni/journal/v17/n4/full/ni.3398.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ni.3398'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni.3398'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ni.3398'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni.3398'


 

This table displays all metadata directly associated to this object as RDF triples.

546 TRIPLES      21 PREDICATES      120 URIs      53 LITERALS      41 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ni.3398 schema:about N1613ebd76afe4398be288ad2ef0c701e
2 N258c2d6ecd304b73a2eb3d940ce72494
3 N2ad2a72677d443d0bcdc3a7e51cb114f
4 N2fb8517303624c1faeaff55f4b62d451
5 N3d341dacf9b24521bb3330bc82ed1412
6 N410edca5b451494d9908ab3d9bc9369e
7 N4e3e1609c43b41b6b23b3eb481014065
8 N5601185ea90d48c08874c3214d1f837c
9 N5c5ad2d7814841819e9779cb8bf8d121
10 N5de95224de184dfdb216d0023226f230
11 N6495f0c9b89040bfa4ca720d0f2ed4e7
12 N79818e83f7ee4d808f2d8ff2469d4e55
13 N81c1462a944d4d88b970e748e9189877
14 N8c1579a9b1714125b5bfdbae5006d8a5
15 N8f821d34acd748b68a0180e8c552f793
16 N919a8f1f453541bcbe6bbf9e3aa43766
17 N934478c8832f411ea4ec83e8016211f9
18 N997d237fdf5b4b4da58d7e4812381209
19 N9a794db4c7134e5f9d066b39ae67b159
20 N9eb6efec3ac44a10843a806d9e7a08be
21 N9edf5a8d8cca4c9eaaa77560bb52825f
22 Na089b97254374c6c93e4ae042d10dc5a
23 Na93abcf1f5ba47cb890749524c1a652b
24 Nb3417a77201c403284702272154112a8
25 Nb391ace142a94d3f89c1ec4d46c1fb73
26 Nb98d48663185473d897b8c8afce98ecb
27 Nc2f468b46d8b4271b50fb9e48447c348
28 Ne2b381141a3049a3b331bd0c88e93949
29 Ne3b02cc2a2f645bd819ff53174bc928b
30 Ne7221b7c2e1b4db183acd6828c6cb9ad
31 Ne925c9ddd55d4d9c98945ab74a5aaa73
32 Nfb856700a0b24a62a937c8d10159b919
33 anzsrc-for:11
34 anzsrc-for:1103
35 schema:author Na29a34004b4f4b63b894627f81b94fb3
36 schema:citation sg:pub.10.1007/s10059-013-0169-8
37 sg:pub.10.1038/icb.2013.37
38 sg:pub.10.1038/nature03985
39 sg:pub.10.1038/nature11986
40 sg:pub.10.1038/ncomms1667
41 sg:pub.10.1038/ncomms2343
42 sg:pub.10.1038/ni.3205
43 sg:pub.10.1038/nm0697-678
44 sg:pub.10.1038/nri3901
45 sg:pub.10.1186/1471-2334-14-166
46 sg:pub.10.1186/1478-811x-10-41
47 sg:pub.10.1186/gb-2004-5-10-r80
48 https://doi.org/10.1002/prca.200800016
49 https://doi.org/10.1016/j.bbabio.2008.04.024
50 https://doi.org/10.1016/j.ccm.2008.06.003
51 https://doi.org/10.1016/j.cmet.2006.05.011
52 https://doi.org/10.1016/j.cytogfr.2014.06.008
53 https://doi.org/10.1016/j.freeradbiomed.2009.08.019
54 https://doi.org/10.1016/j.immuni.2013.08.009
55 https://doi.org/10.1016/j.immuni.2015.02.001
56 https://doi.org/10.1016/s0140-6736(02)09459-x
57 https://doi.org/10.1021/pr801006e
58 https://doi.org/10.1056/nejmra1208623
59 https://doi.org/10.1073/pnas.0914005107
60 https://doi.org/10.1074/jbc.m112.362343
61 https://doi.org/10.1093/bioinformatics/19.2.185
62 https://doi.org/10.1093/bioinformatics/btg405
63 https://doi.org/10.1093/bioinformatics/btm311
64 https://doi.org/10.1093/bioinformatics/btn647
65 https://doi.org/10.1093/biostatistics/kxj037
66 https://doi.org/10.1093/nar/gki624
67 https://doi.org/10.1093/nar/gkm427
68 https://doi.org/10.1093/nar/gkp427
69 https://doi.org/10.1093/nar/gkr984
70 https://doi.org/10.1097/00003246-198510000-00009
71 https://doi.org/10.1097/01.ccm.0000295593.25106.c4
72 https://doi.org/10.1097/ccm.0000000000000949
73 https://doi.org/10.1097/ccm.0b013e3182923712
74 https://doi.org/10.1100/2011/397971
75 https://doi.org/10.1126/science.1250684
76 https://doi.org/10.1126/science.1251086
77 https://doi.org/10.1128/mmbr.69.1.79-100.2005
78 https://doi.org/10.1159/000321365
79 https://doi.org/10.1161/circheartfailure.112.000177
80 https://doi.org/10.1164/rccm.201003-0326oc
81 https://doi.org/10.1164/rccm.201204-0645oc
82 https://doi.org/10.1164/rccm.201307-1376oc
83 https://doi.org/10.1165/rcmb.2013-0015oc
84 https://doi.org/10.1371/journal.pbio.1001759
85 https://doi.org/10.1371/journal.pgen.0030161
86 https://doi.org/10.1371/journal.pone.0079051
87 https://doi.org/10.1586/1744666x.2014.943192
88 https://doi.org/10.2174/187152010793498663
89 https://doi.org/10.3109/08830185.2014.969421
90 https://doi.org/10.3389/fimmu.2014.00680
91 https://doi.org/10.4049/jimmunol.0901698
92 https://doi.org/10.4049/jimmunol.1302375
93 https://doi.org/10.4049/jimmunol.1402077
94 https://doi.org/10.7164/antibiotics.28.721
95 schema:datePublished 2016-04
96 schema:datePublishedReg 2016-04-01
97 schema:description The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages in some patients, immunoparalysis may be encountered, which is associated with a poor outcome. By transcriptional and metabolic profiling of human patients with sepsis, we found that a shift from oxidative phosphorylation to aerobic glycolysis was an important component of initial activation of host defense. Blocking metabolic pathways with metformin diminished cytokine production and increased mortality in systemic fungal infection in mice. In contrast, in leukocytes rendered tolerant by exposure to lipopolysaccharide or after isolation from patients with sepsis and immunoparalysis, a generalized metabolic defect at the level of both glycolysis and oxidative metabolism was apparent, which was restored after recovery of the patients. Finally, the immunometabolic defects in humans were partially restored by therapy with recombinant interferon-γ, which suggested that metabolic processes might represent a therapeutic target in sepsis.
98 schema:genre research_article
99 schema:inLanguage en
100 schema:isAccessibleForFree false
101 schema:isPartOf N93fd3998254849ed97d7ddde6e428f6e
102 Ndde7e085f26f43e9bd7bcc93065c4271
103 sg:journal.1022778
104 schema:name Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis
105 schema:pagination 406-413
106 schema:productId N7d2725460d6a463baf6953451df647c8
107 N81b36c476359453c84c44265fc67c59f
108 Nb9a097b831a54e189891683f5d09c62e
109 Ne1117435ca0342dbad08a32ae60a0a92
110 Nee07ed476a724ba381cca2f28013384e
111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043334409
112 https://doi.org/10.1038/ni.3398
113 schema:sdDatePublished 2019-04-10T19:00
114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
115 schema:sdPublisher N3d365d5aa0074679926b81b2cd49ab0b
116 schema:url http://www.nature.com/ni/journal/v17/n4/full/ni.3398.html
117 sgo:license sg:explorer/license/
118 sgo:sdDataset articles
119 rdf:type schema:ScholarlyArticle
120 N04dad546e09d483ba209eec9de610a76 rdf:first sg:person.014610477307.37
121 rdf:rest N21bb08ace2ab4e1a86c4070b2286f59f
122 N0abadcafed2d4fa6902e09e064771d99 rdf:first sg:person.01114466025.29
123 rdf:rest N5b1d575463894f8db1575d9ecf64fd86
124 N1613ebd76afe4398be288ad2ef0c701e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Glycolysis
126 rdf:type schema:DefinedTerm
127 N21bb08ace2ab4e1a86c4070b2286f59f rdf:first sg:person.01257242266.18
128 rdf:rest Naaa52c8b5df347f1b2826cacab8e3de4
129 N258c2d6ecd304b73a2eb3d940ce72494 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Leukocytes
131 rdf:type schema:DefinedTerm
132 N2850696155be4cc986ec4b9da1b4dbff rdf:first sg:person.01200544270.76
133 rdf:rest Nf34b0ea21dea4acc956d66b48e3958be
134 N285fcfaec85640769e71bdafb2a1119d schema:name Center of Experimental & Molecular Medicine, Division of Infectious Diseases, Amsterdam Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
135 rdf:type schema:Organization
136 N2ad2a72677d443d0bcdc3a7e51cb114f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Immunoblotting
138 rdf:type schema:DefinedTerm
139 N2fb8517303624c1faeaff55f4b62d451 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Antifungal Agents
141 rdf:type schema:DefinedTerm
142 N3d341dacf9b24521bb3330bc82ed1412 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Sepsis
144 rdf:type schema:DefinedTerm
145 N3d365d5aa0074679926b81b2cd49ab0b schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 N410edca5b451494d9908ab3d9bc9369e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Female
149 rdf:type schema:DefinedTerm
150 N41112848bfe740c59bf8443f64c1221d rdf:first sg:person.01141407025.78
151 rdf:rest N04dad546e09d483ba209eec9de610a76
152 N4e3e1609c43b41b6b23b3eb481014065 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Young Adult
154 rdf:type schema:DefinedTerm
155 N514667e9a94e4399999ccd349b8f5f71 rdf:first sg:person.0622036530.51
156 rdf:rest Nf8f73f1e19fc4acf82ffa906091fcad6
157 N5601185ea90d48c08874c3214d1f837c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Cytokines
159 rdf:type schema:DefinedTerm
160 N5b1d575463894f8db1575d9ecf64fd86 rdf:first sg:person.01047711423.48
161 rdf:rest N9d66d0591211454b8bc79721fb274475
162 N5c5ad2d7814841819e9779cb8bf8d121 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Adult
164 rdf:type schema:DefinedTerm
165 N5de95224de184dfdb216d0023226f230 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Oxidative Phosphorylation
167 rdf:type schema:DefinedTerm
168 N6495f0c9b89040bfa4ca720d0f2ed4e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Animals
170 rdf:type schema:DefinedTerm
171 N79818e83f7ee4d808f2d8ff2469d4e55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Lactic Acid
173 rdf:type schema:DefinedTerm
174 N7ab209bd35ff45f88ccaf6b3c6c6074e rdf:first sg:person.010710050004.99
175 rdf:rest N864b6f47fcfa4306908c214ebbaa5766
176 N7d2725460d6a463baf6953451df647c8 schema:name nlm_unique_id
177 schema:value 100941354
178 rdf:type schema:PropertyValue
179 N81b36c476359453c84c44265fc67c59f schema:name dimensions_id
180 schema:value pub.1043334409
181 rdf:type schema:PropertyValue
182 N81c1462a944d4d88b970e748e9189877 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Escherichia coli Infections
184 rdf:type schema:DefinedTerm
185 N864b6f47fcfa4306908c214ebbaa5766 rdf:first sg:person.01007146366.19
186 rdf:rest Nf4ba182bfd4d41b994265d8fd5da2da9
187 N8c1579a9b1714125b5bfdbae5006d8a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Macrophages
189 rdf:type schema:DefinedTerm
190 N8f821d34acd748b68a0180e8c552f793 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Energy Metabolism
192 rdf:type schema:DefinedTerm
193 N919a8f1f453541bcbe6bbf9e3aa43766 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Candidiasis, Invasive
195 rdf:type schema:DefinedTerm
196 N934478c8832f411ea4ec83e8016211f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Prospective Studies
198 rdf:type schema:DefinedTerm
199 N93fd3998254849ed97d7ddde6e428f6e schema:issueNumber 4
200 rdf:type schema:PublicationIssue
201 N98e4e70e4c064a6091ff409bd8cff4ef rdf:first sg:person.01116645416.05
202 rdf:rest Na9344634f7b44fe2b57bf9325cc895cb
203 N997d237fdf5b4b4da58d7e4812381209 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Adenosine Triphosphate
205 rdf:type schema:DefinedTerm
206 N9a794db4c7134e5f9d066b39ae67b159 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Male
208 rdf:type schema:DefinedTerm
209 N9d66d0591211454b8bc79721fb274475 rdf:first sg:person.01035404167.27
210 rdf:rest Ndd83d368fb924bb59b1e1aad5c88df8f
211 N9eb6efec3ac44a10843a806d9e7a08be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Interferon-gamma
213 rdf:type schema:DefinedTerm
214 N9edf5a8d8cca4c9eaaa77560bb52825f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Immune Tolerance
216 rdf:type schema:DefinedTerm
217 Na089b97254374c6c93e4ae042d10dc5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Monocytes
219 rdf:type schema:DefinedTerm
220 Na29a34004b4f4b63b894627f81b94fb3 rdf:first sg:person.01233444754.71
221 rdf:rest N41112848bfe740c59bf8443f64c1221d
222 Na7c0dfdd2e134118895f22e98ec35fe4 rdf:first sg:person.01263677437.18
223 rdf:rest rdf:nil
224 Na9344634f7b44fe2b57bf9325cc895cb rdf:first sg:person.01117674501.17
225 rdf:rest N0abadcafed2d4fa6902e09e064771d99
226 Na93abcf1f5ba47cb890749524c1a652b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Mice
228 rdf:type schema:DefinedTerm
229 Naaa52c8b5df347f1b2826cacab8e3de4 rdf:first sg:person.01074074465.58
230 rdf:rest N98e4e70e4c064a6091ff409bd8cff4ef
231 Nad991a031f5041a9b3005bad30a2feab rdf:first sg:person.01065476534.34
232 rdf:rest Na7c0dfdd2e134118895f22e98ec35fe4
233 Nb3417a77201c403284702272154112a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
234 schema:name Lipopolysaccharides
235 rdf:type schema:DefinedTerm
236 Nb391ace142a94d3f89c1ec4d46c1fb73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
237 schema:name Transcriptome
238 rdf:type schema:DefinedTerm
239 Nb98d48663185473d897b8c8afce98ecb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Oxygen Consumption
241 rdf:type schema:DefinedTerm
242 Nb9a097b831a54e189891683f5d09c62e schema:name readcube_id
243 schema:value ce6b293750d67e5494db47e032d479460d4537c9dacfdfac64f139fa17a52661
244 rdf:type schema:PropertyValue
245 Nc2f468b46d8b4271b50fb9e48447c348 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
246 schema:name Endotoxemia
247 rdf:type schema:DefinedTerm
248 Nd189b429a68e4a118510fa22da464234 schema:name Center of Experimental & Molecular Medicine, Division of Infectious Diseases, Amsterdam Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
249 rdf:type schema:Organization
250 Ndd83d368fb924bb59b1e1aad5c88df8f rdf:first sg:person.0751251524.50
251 rdf:rest N2850696155be4cc986ec4b9da1b4dbff
252 Ndde7e085f26f43e9bd7bcc93065c4271 schema:volumeNumber 17
253 rdf:type schema:PublicationVolume
254 Ne1117435ca0342dbad08a32ae60a0a92 schema:name pubmed_id
255 schema:value 26950237
256 rdf:type schema:PropertyValue
257 Ne2b381141a3049a3b331bd0c88e93949 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
258 schema:name Immunity, Innate
259 rdf:type schema:DefinedTerm
260 Ne3b02cc2a2f645bd819ff53174bc928b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
261 schema:name Humans
262 rdf:type schema:DefinedTerm
263 Ne7221b7c2e1b4db183acd6828c6cb9ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
264 schema:name Aspergillosis
265 rdf:type schema:DefinedTerm
266 Ne925c9ddd55d4d9c98945ab74a5aaa73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
267 schema:name NAD
268 rdf:type schema:DefinedTerm
269 Nee07ed476a724ba381cca2f28013384e schema:name doi
270 schema:value 10.1038/ni.3398
271 rdf:type schema:PropertyValue
272 Nf34b0ea21dea4acc956d66b48e3958be rdf:first sg:person.01311216724.81
273 rdf:rest N7ab209bd35ff45f88ccaf6b3c6c6074e
274 Nf4ba182bfd4d41b994265d8fd5da2da9 rdf:first sg:person.010154322272.51
275 rdf:rest N514667e9a94e4399999ccd349b8f5f71
276 Nf8f73f1e19fc4acf82ffa906091fcad6 rdf:first sg:person.014645240657.77
277 rdf:rest Nad991a031f5041a9b3005bad30a2feab
278 Nfb856700a0b24a62a937c8d10159b919 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
279 schema:name Middle Aged
280 rdf:type schema:DefinedTerm
281 Nfc896fd5133b43bea72ee15bb7f15d41 schema:name Center of Experimental & Molecular Medicine, Division of Infectious Diseases, Amsterdam Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
282 rdf:type schema:Organization
283 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
284 schema:name Medical and Health Sciences
285 rdf:type schema:DefinedTerm
286 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
287 schema:name Clinical Sciences
288 rdf:type schema:DefinedTerm
289 sg:grant.3797303 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.3398
290 rdf:type schema:MonetaryGrant
291 sg:journal.1022778 schema:issn 1529-2908
292 1529-2916
293 schema:name Nature Immunology
294 rdf:type schema:Periodical
295 sg:person.01007146366.19 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
296 schema:familyName Schultz
297 schema:givenName Marcus J
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007146366.19
299 rdf:type schema:Person
300 sg:person.010154322272.51 schema:affiliation https://www.grid.ac/institutes/grid.461760.2
301 schema:familyName Willems
302 schema:givenName Peter H G M
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010154322272.51
304 rdf:type schema:Person
305 sg:person.01035404167.27 schema:affiliation https://www.grid.ac/institutes/grid.7692.a
306 schema:familyName Cremer
307 schema:givenName Olaf L
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035404167.27
309 rdf:type schema:Person
310 sg:person.01047711423.48 schema:affiliation https://www.grid.ac/institutes/grid.461760.2
311 schema:familyName Wagenaars
312 schema:givenName Jori A L
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047711423.48
314 rdf:type schema:Person
315 sg:person.01065476534.34 schema:affiliation Nfc896fd5133b43bea72ee15bb7f15d41
316 schema:familyName van der Poll
317 schema:givenName Tom
318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065476534.34
319 rdf:type schema:Person
320 sg:person.010710050004.99 schema:affiliation https://www.grid.ac/institutes/grid.7692.a
321 schema:familyName Bonten
322 schema:givenName Marc J
323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010710050004.99
324 rdf:type schema:Person
325 sg:person.01074074465.58 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
326 schema:familyName Lachmandas
327 schema:givenName Ekta
328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074074465.58
329 rdf:type schema:Person
330 sg:person.01114466025.29 schema:affiliation https://www.grid.ac/institutes/grid.6572.6
331 schema:familyName Manjeri
332 schema:givenName Ganesh R
333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114466025.29
334 rdf:type schema:Person
335 sg:person.01116645416.05 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
336 schema:familyName Giamarellos-Bourboulis
337 schema:givenName Evangelos J
338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116645416.05
339 rdf:type schema:Person
340 sg:person.01117674501.17 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
341 schema:familyName Kox
342 schema:givenName Matthijs
343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117674501.17
344 rdf:type schema:Person
345 sg:person.01141407025.78 schema:affiliation N285fcfaec85640769e71bdafb2a1119d
346 schema:familyName Scicluna
347 schema:givenName Brendon P
348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141407025.78
349 rdf:type schema:Person
350 sg:person.01200544270.76 schema:affiliation Nd189b429a68e4a118510fa22da464234
351 schema:familyName van der Meer
352 schema:givenName Anne J
353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200544270.76
354 rdf:type schema:Person
355 sg:person.01233444754.71 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
356 schema:familyName Cheng
357 schema:givenName Shih-Chin
358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233444754.71
359 rdf:type schema:Person
360 sg:person.01257242266.18 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
361 schema:familyName Gresnigt
362 schema:givenName Mark S
363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257242266.18
364 rdf:type schema:Person
365 sg:person.01263677437.18 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
366 schema:familyName Netea
367 schema:givenName Mihai G
368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263677437.18
369 rdf:type schema:Person
370 sg:person.01311216724.81 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
371 schema:familyName van de Veerdonk
372 schema:givenName Frank L
373 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311216724.81
374 rdf:type schema:Person
375 sg:person.014610477307.37 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
376 schema:familyName Arts
377 schema:givenName Rob J W
378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014610477307.37
379 rdf:type schema:Person
380 sg:person.014645240657.77 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
381 schema:familyName Joosten
382 schema:givenName Leo A B
383 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014645240657.77
384 rdf:type schema:Person
385 sg:person.0622036530.51 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
386 schema:familyName Pickkers
387 schema:givenName Peter
388 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622036530.51
389 rdf:type schema:Person
390 sg:person.0751251524.50 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
391 schema:familyName Leentjens
392 schema:givenName Jenneke
393 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751251524.50
394 rdf:type schema:Person
395 sg:pub.10.1007/s10059-013-0169-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046946266
396 https://doi.org/10.1007/s10059-013-0169-8
397 rdf:type schema:CreativeWork
398 sg:pub.10.1038/icb.2013.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040202826
399 https://doi.org/10.1038/icb.2013.37
400 rdf:type schema:CreativeWork
401 sg:pub.10.1038/nature03985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010326831
402 https://doi.org/10.1038/nature03985
403 rdf:type schema:CreativeWork
404 sg:pub.10.1038/nature11986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051643661
405 https://doi.org/10.1038/nature11986
406 rdf:type schema:CreativeWork
407 sg:pub.10.1038/ncomms1667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025863486
408 https://doi.org/10.1038/ncomms1667
409 rdf:type schema:CreativeWork
410 sg:pub.10.1038/ncomms2343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024567785
411 https://doi.org/10.1038/ncomms2343
412 rdf:type schema:CreativeWork
413 sg:pub.10.1038/ni.3205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017102595
414 https://doi.org/10.1038/ni.3205
415 rdf:type schema:CreativeWork
416 sg:pub.10.1038/nm0697-678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026465919
417 https://doi.org/10.1038/nm0697-678
418 rdf:type schema:CreativeWork
419 sg:pub.10.1038/nri3901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007525476
420 https://doi.org/10.1038/nri3901
421 rdf:type schema:CreativeWork
422 sg:pub.10.1186/1471-2334-14-166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014226015
423 https://doi.org/10.1186/1471-2334-14-166
424 rdf:type schema:CreativeWork
425 sg:pub.10.1186/1478-811x-10-41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041070938
426 https://doi.org/10.1186/1478-811x-10-41
427 rdf:type schema:CreativeWork
428 sg:pub.10.1186/gb-2004-5-10-r80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018457673
429 https://doi.org/10.1186/gb-2004-5-10-r80
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1002/prca.200800016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001124221
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1016/j.bbabio.2008.04.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003420803
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1016/j.ccm.2008.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000936972
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1016/j.cmet.2006.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040848247
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1016/j.cytogfr.2014.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012497093
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1016/j.freeradbiomed.2009.08.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027313040
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1016/j.immuni.2013.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045055863
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1016/j.immuni.2015.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037365100
446 rdf:type schema:CreativeWork
447 https://doi.org/10.1016/s0140-6736(02)09459-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006354524
448 rdf:type schema:CreativeWork
449 https://doi.org/10.1021/pr801006e schema:sameAs https://app.dimensions.ai/details/publication/pub.1056294743
450 rdf:type schema:CreativeWork
451 https://doi.org/10.1056/nejmra1208623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032706237
452 rdf:type schema:CreativeWork
453 https://doi.org/10.1073/pnas.0914005107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011637541
454 rdf:type schema:CreativeWork
455 https://doi.org/10.1074/jbc.m112.362343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053354635
456 rdf:type schema:CreativeWork
457 https://doi.org/10.1093/bioinformatics/19.2.185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011853799
458 rdf:type schema:CreativeWork
459 https://doi.org/10.1093/bioinformatics/btg405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003878496
460 rdf:type schema:CreativeWork
461 https://doi.org/10.1093/bioinformatics/btm311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042939614
462 rdf:type schema:CreativeWork
463 https://doi.org/10.1093/bioinformatics/btn647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043301996
464 rdf:type schema:CreativeWork
465 https://doi.org/10.1093/biostatistics/kxj037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016217055
466 rdf:type schema:CreativeWork
467 https://doi.org/10.1093/nar/gki624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006993826
468 rdf:type schema:CreativeWork
469 https://doi.org/10.1093/nar/gkm427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034144948
470 rdf:type schema:CreativeWork
471 https://doi.org/10.1093/nar/gkp427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027845966
472 rdf:type schema:CreativeWork
473 https://doi.org/10.1093/nar/gkr984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002391987
474 rdf:type schema:CreativeWork
475 https://doi.org/10.1097/00003246-198510000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039110630
476 rdf:type schema:CreativeWork
477 https://doi.org/10.1097/01.ccm.0000295593.25106.c4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008497320
478 rdf:type schema:CreativeWork
479 https://doi.org/10.1097/ccm.0000000000000949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032886629
480 rdf:type schema:CreativeWork
481 https://doi.org/10.1097/ccm.0b013e3182923712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019418606
482 rdf:type schema:CreativeWork
483 https://doi.org/10.1100/2011/397971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022014723
484 rdf:type schema:CreativeWork
485 https://doi.org/10.1126/science.1250684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045685233
486 rdf:type schema:CreativeWork
487 https://doi.org/10.1126/science.1251086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035224090
488 rdf:type schema:CreativeWork
489 https://doi.org/10.1128/mmbr.69.1.79-100.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045767507
490 rdf:type schema:CreativeWork
491 https://doi.org/10.1159/000321365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049453821
492 rdf:type schema:CreativeWork
493 https://doi.org/10.1161/circheartfailure.112.000177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032123194
494 rdf:type schema:CreativeWork
495 https://doi.org/10.1164/rccm.201003-0326oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1038668601
496 rdf:type schema:CreativeWork
497 https://doi.org/10.1164/rccm.201204-0645oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1040357028
498 rdf:type schema:CreativeWork
499 https://doi.org/10.1164/rccm.201307-1376oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1049847752
500 rdf:type schema:CreativeWork
501 https://doi.org/10.1165/rcmb.2013-0015oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1032002151
502 rdf:type schema:CreativeWork
503 https://doi.org/10.1371/journal.pbio.1001759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013540250
504 rdf:type schema:CreativeWork
505 https://doi.org/10.1371/journal.pgen.0030161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009683731
506 rdf:type schema:CreativeWork
507 https://doi.org/10.1371/journal.pone.0079051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016567898
508 rdf:type schema:CreativeWork
509 https://doi.org/10.1586/1744666x.2014.943192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035934150
510 rdf:type schema:CreativeWork
511 https://doi.org/10.2174/187152010793498663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069218346
512 rdf:type schema:CreativeWork
513 https://doi.org/10.3109/08830185.2014.969421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021028383
514 rdf:type schema:CreativeWork
515 https://doi.org/10.3389/fimmu.2014.00680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038906616
516 rdf:type schema:CreativeWork
517 https://doi.org/10.4049/jimmunol.0901698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005113830
518 rdf:type schema:CreativeWork
519 https://doi.org/10.4049/jimmunol.1302375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078850405
520 rdf:type schema:CreativeWork
521 https://doi.org/10.4049/jimmunol.1402077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079053280
522 rdf:type schema:CreativeWork
523 https://doi.org/10.7164/antibiotics.28.721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073629937
524 rdf:type schema:CreativeWork
525 https://www.grid.ac/institutes/grid.10417.33 schema:alternateName Radboud University Nijmegen Medical Centre
526 schema:name Department of Intensive Care and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
527 Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
528 rdf:type schema:Organization
529 https://www.grid.ac/institutes/grid.461760.2 schema:alternateName Radboud Institute for Molecular Life Sciences
530 schema:name Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands.
531 rdf:type schema:Organization
532 https://www.grid.ac/institutes/grid.5216.0 schema:alternateName National and Kapodistrian University of Athens
533 schema:name 4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece.
534 rdf:type schema:Organization
535 https://www.grid.ac/institutes/grid.6572.6 schema:alternateName University of Birmingham
536 schema:name Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands.
537 Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
538 rdf:type schema:Organization
539 https://www.grid.ac/institutes/grid.7177.6 schema:alternateName University of Amsterdam
540 schema:name Department of Intensive Care Medicine Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
541 rdf:type schema:Organization
542 https://www.grid.ac/institutes/grid.7692.a schema:alternateName University Medical Center Utrecht
543 schema:name Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
544 Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
545 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
546 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...