The cellular composition of the human immune system is shaped by age and cohabitation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-04

AUTHORS

Edward J Carr, James Dooley, Josselyn E Garcia-Perez, Vasiliki Lagou, James C Lee, Carine Wouters, Isabelle Meyts, An Goris, Guy Boeckxstaens, Michelle A Linterman, Adrian Liston

ABSTRACT

Detailed population-level description of the human immune system has recently become achievable. We used a 'systems-level' approach to establish a resource of cellular immune profiles of 670 healthy individuals. We report a high level of interindividual variation, with low longitudinal variation, at the level of cellular subset composition of the immune system. Despite the profound effects of antigen exposure on individual antigen-specific clones, the cellular subset structure proved highly elastic, with transient vaccination-induced changes followed by a return to the individual's unique baseline. Notably, the largest influence on immunological variation identified was cohabitation, with 50% less immunological variation between individuals who share an environment (as parents) than between people in the wider population. These results identify local environmental conditions as a key factor in shaping the human immune system. More... »

PAGES

461-468

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni.3371

DOI

http://dx.doi.org/10.1038/ni.3371

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010629939

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26878114


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