Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-08

AUTHORS

Cornelia Lindner, Irene Thomsen, Benjamin Wahl, Milas Ugur, Maya K Sethi, Michaela Friedrichsen, Anna Smoczek, Stephan Ott, Ulrich Baumann, Sebastian Suerbaum, Stefan Schreiber, André Bleich, Valérie Gaboriau-Routhiau, Nadine Cerf-Bensussan, Helena Hazanov, Ramit Mehr, Preben Boysen, Philip Rosenstiel, Oliver Pabst

ABSTRACT

Secretory immunoglobulin A (SIgA) shields the gut epithelium from luminal antigens and contributes to host-microbe symbiosis. However, how antibody responses are regulated to achieve sustained host-microbe interactions is unknown. We found that mice and humans exhibited longitudinal persistence of clonally related B cells in the IgA repertoire despite major changes in the microbiota during antibiotic treatment or infection. Memory B cells recirculated between inductive compartments and were clonally related to plasma cells in gut and mammary glands. Our findings suggest that continuous diversification of memory B cells constitutes a central process for establishing symbiotic host-microbe interactions and offer an explanation of how maternal antibodies are optimized throughout life to protect the newborn. More... »

PAGES

880-888

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.3213

    DOI

    http://dx.doi.org/10.1038/ni.3213

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035747387

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26147688


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