Diversification of TAM receptor tyrosine kinase function View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-09-07

AUTHORS

Anna Zagórska, Paqui G Través, Erin D Lew, Ian Dransfield, Greg Lemke

ABSTRACT

The clearance of apoptotic cells is critical for both tissue homeostasis and the resolution of inflammation. We found that the TAM receptor tyrosine kinases Axl and Mer had distinct roles as phagocytic receptors in these two settings, in which they exhibited divergent expression, regulation and activity. Mer acted as a tolerogenic receptor in resting macrophages and during immunosuppression. In contrast, Axl was an inflammatory response receptor whose expression was induced by proinflammatory stimuli. Axl and Mer differed in their ligand specificities, ligand-receptor complex formation in tissues, and receptor shedding upon activation. These differences notwithstanding, phagocytosis by either protein was strictly dependent on receptor activation triggered by bridging of TAM receptor-ligand complexes to the 'eat-me' signal phosphatidylserine on the surface of apoptotic cells. More... »

PAGES

920-928

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni.2986

DOI

http://dx.doi.org/10.1038/ni.2986

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046332407

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25194421


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