Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-01

AUTHORS

Melanie Wencker, Gleb Turchinovich, Rafael Di Marco Barros, Livija Deban, Anett Jandke, Andrew Cope, Adrian C Hayday

ABSTRACT

The subclassification of immunology into innate and adaptive immunity is challenged by innate-like T lymphocytes that use innate receptors to respond rapidly to stress despite expressing T cell antigen receptors (TCRs), a hallmark of adaptive immunity. In studies that explain how such cells can straddle innate and adaptive immunity, we found that signaling via antigen receptors, whose conventional role is to facilitate clonal T cell activation, was critical for the development of innate-like T cells but then was rapidly attenuated, which accommodated the cells' innate responsiveness. These findings permitted the identification of a previously unknown innate-like T cell subset and indicate that T cell hyporesponsiveness, a state traditionally linked to tolerance, may be fundamental to T cells entering the innate compartment and thereby providing lymphoid stress surveillance. More... »

PAGES

80-87

References to SciGraph publications

  • 2013-02. Six-of-the-best: unique contributions of γδ T cells to immunology in NATURE REVIEWS IMMUNOLOGY
  • 2012-03. Body-barrier surveillance by epidermal γδ TCRs in NATURE IMMUNOLOGY
  • 2012-09. Endogenous antigen tunes the responsiveness of naive B cells but not T cells in NATURE
  • 2003-11. Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice in NATURE
  • 2006-08. Selection of the cutaneous intraepithelial γδ+ T cell repertoire by a thymic stromal determinant in NATURE IMMUNOLOGY
  • 2012-08-12. Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor in NATURE IMMUNOLOGY
  • 2010-09. NFAT, immunity and cancer: a transcription factor comes of age in NATURE REVIEWS IMMUNOLOGY
  • 2009-04. CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets in NATURE IMMUNOLOGY
  • 2008-05. Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells in NATURE GENETICS
  • 2006-11. Disruption of diacylglycerol metabolism impairs the induction of T cell anergy in NATURE IMMUNOLOGY
  • 1990-02. Homing of a γδ thymocyte subset with homogeneous T-cell receptors to mucosal epithelia in NATURE
  • 2003-03. Immunoregulation in the tissues by γδ T cells in NATURE REVIEWS IMMUNOLOGY
  • 2012-06. Clonal deletion and the fate of autoreactive thymocytes that survive negative selection in NATURE IMMUNOLOGY
  • 2008-02. Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.2773

    DOI

    http://dx.doi.org/10.1038/ni.2773

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037969525

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24241693


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adaptive Immunity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals, Newborn", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Flow Cytometry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Green Fluorescent Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunity, Innate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-17", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred BALB C", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Transgenic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nuclear Receptor Subfamily 4, Group A, Member 1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Antigen, T-Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Antigen, T-Cell, gamma-delta", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocyte Subsets", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "ZAP-70 Protein-Tyrosine Kinase", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "King's College London", 
              "id": "https://www.grid.ac/institutes/grid.13097.3c", 
              "name": [
                "London Research Institute, Cancer Research UK, London, UK.", 
                "Peter Gorer Department of Immunobiology, King's College London, London, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wencker", 
            "givenName": "Melanie", 
            "id": "sg:person.01233175447.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233175447.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "King's College London", 
              "id": "https://www.grid.ac/institutes/grid.13097.3c", 
              "name": [
                "London Research Institute, Cancer Research UK, London, UK.", 
                "Peter Gorer Department of Immunobiology, King's College London, London, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Turchinovich", 
            "givenName": "Gleb", 
            "id": "sg:person.01163477627.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163477627.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College London", 
              "id": "https://www.grid.ac/institutes/grid.83440.3b", 
              "name": [
                "London Research Institute, Cancer Research UK, London, UK.", 
                "University College London, London, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Di Marco Barros", 
            "givenName": "Rafael", 
            "id": "sg:person.01245362330.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245362330.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "London Research Institute, Cancer Research UK, London, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deban", 
            "givenName": "Livija", 
            "id": "sg:person.0627664041.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627664041.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "London Research Institute, Cancer Research UK, London, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jandke", 
            "givenName": "Anett", 
            "id": "sg:person.01156457215.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156457215.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "King's College London", 
              "id": "https://www.grid.ac/institutes/grid.13097.3c", 
              "name": [
                "Centre for the Molecular and Cell Biology of Inflammation, King's College London, London, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cope", 
            "givenName": "Andrew", 
            "id": "sg:person.0622005006.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622005006.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "King's College London", 
              "id": "https://www.grid.ac/institutes/grid.13097.3c", 
              "name": [
                "London Research Institute, Cancer Research UK, London, UK.", 
                "Peter Gorer Department of Immunobiology, King's College London, London, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hayday", 
            "givenName": "Adrian C", 
            "id": "sg:person.0650365131.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650365131.57"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1126/science.1069639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002697167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003971889", 
              "https://doi.org/10.1038/nri1030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003971889", 
              "https://doi.org/10.1038/nri1030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molimm.2013.03.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004596303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004633454", 
              "https://doi.org/10.1038/nature11311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004728396", 
              "https://doi.org/10.1038/ni1363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004728396", 
              "https://doi.org/10.1038/ni1363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2818", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005689832", 
              "https://doi.org/10.1038/nri2818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2818", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005689832", 
              "https://doi.org/10.1038/nri2818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006653799", 
              "https://doi.org/10.1038/ni.2394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006653799", 
              "https://doi.org/10.1038/ni.2394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(02)00284-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009133843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/smim.1998.0136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009598447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3384", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010014687", 
              "https://doi.org/10.1038/nri3384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.04.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010554640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1134301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010751773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1204327109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013271437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1204327109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013271437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.08.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016266241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20111024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016647099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1001589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022492607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cyto.a.10072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022701923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1192698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024192657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.181.5.3456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024746225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.177.7.4662", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027260536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2011.04.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028160472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2010.08.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029780340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030665392", 
              "https://doi.org/10.1038/nature02119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030665392", 
              "https://doi.org/10.1038/nature02119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20101824", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031606481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2012.06.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032389822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032395563", 
              "https://doi.org/10.1038/ni.2292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033450095", 
              "https://doi.org/10.1038/ni1556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2011.08.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033896817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034118078", 
              "https://doi.org/10.1038/ni.1717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034118078", 
              "https://doi.org/10.1038/ni.1717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.18.9704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035251951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0906988106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040078409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.181.3.1627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040775157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(01)00097-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043218364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200939922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044104681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2012.06.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044464899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/343754a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046540947", 
              "https://doi.org/10.1038/343754a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048242401", 
              "https://doi.org/10.1038/ng.108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.08.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048883448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1002781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049604876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-020711-075053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050933093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2004.06.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051310437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-05-352732", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051393800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.81.13.4169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051518687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051558015", 
              "https://doi.org/10.1038/ni.2240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.smim.2010.04.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051756767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.1994.tb00894.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052190626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20110308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052758594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053206259", 
              "https://doi.org/10.1038/ni1400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053206259", 
              "https://doi.org/10.1038/ni1400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1211250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062465505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.279.5357.1729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062559933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.180.3.1442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077593495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.181.9.5940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077798825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fasebj.8.15.8001745", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082603376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083332955", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-01", 
        "datePublishedReg": "2014-01-01", 
        "description": "The subclassification of immunology into innate and adaptive immunity is challenged by innate-like T lymphocytes that use innate receptors to respond rapidly to stress despite expressing T cell antigen receptors (TCRs), a hallmark of adaptive immunity. In studies that explain how such cells can straddle innate and adaptive immunity, we found that signaling via antigen receptors, whose conventional role is to facilitate clonal T cell activation, was critical for the development of innate-like T cells but then was rapidly attenuated, which accommodated the cells' innate responsiveness. These findings permitted the identification of a previously unknown innate-like T cell subset and indicate that T cell hyporesponsiveness, a state traditionally linked to tolerance, may be fundamental to T cells entering the innate compartment and thereby providing lymphoid stress surveillance. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ni.2773", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1022778", 
            "issn": [
              "1529-2908", 
              "1529-2916"
            ], 
            "name": "Nature Immunology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "15"
          }
        ], 
        "name": "Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness", 
        "pagination": "80-87", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b4dfc487c5eea230ca76378230de11d462ede4ed6a60c2a80548fc7f8c60e565"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24241693"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100941354"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ni.2773"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1037969525"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ni.2773", 
          "https://app.dimensions.ai/details/publication/pub.1037969525"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:32", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000466.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/ni.2773"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ni.2773'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni.2773'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ni.2773'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni.2773'


     

    This table displays all metadata directly associated to this object as RDF triples.

    368 TRIPLES      21 PREDICATES      101 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ni.2773 schema:about N11cb28ff9f704bd994e756dfe046ca27
    2 N3a583531468f43b78468e26d710e9ae7
    3 N4bf0f7b1866b4875ae8ddc565e2f87c7
    4 N58c9e7cfca54437e80db4909ef7d144a
    5 N69737eec3d0949e8b27a9a9d842cc5a1
    6 N7cbf76f62be04cdc979db275ea1d1056
    7 N810c513c06d04ffa971381603f84d257
    8 N811add5ca7fa4aa080a33808a99bbfb5
    9 N8983129d6b364c819993ed3906a4a319
    10 N8fc6e8b6eb73462c94c69a4d9d807099
    11 N93fe205c848c44daa9d851705fa6cd44
    12 N9c1380011e52465d82c7a4c713fa7244
    13 Nb6cbc82932eb421e854d70ca16b0b9c1
    14 Nbc9002a2fc434505b1d208d5f9337db7
    15 Nbe65eb1624d247cea5def501d829981b
    16 Ndcaa262270d44c8e8f8b77ac6dd8f711
    17 Nf648982d23f64d8ab66e05baf6f663c0
    18 Nfb0fb7a93e8b48e58c68ec106a64aac3
    19 anzsrc-for:11
    20 anzsrc-for:1107
    21 schema:author Ne9940d3a0bf847999a474eaefd00813c
    22 schema:citation sg:pub.10.1038/343754a0
    23 sg:pub.10.1038/nature02119
    24 sg:pub.10.1038/nature11311
    25 sg:pub.10.1038/ng.108
    26 sg:pub.10.1038/ni.1717
    27 sg:pub.10.1038/ni.2240
    28 sg:pub.10.1038/ni.2292
    29 sg:pub.10.1038/ni.2394
    30 sg:pub.10.1038/ni1363
    31 sg:pub.10.1038/ni1400
    32 sg:pub.10.1038/ni1556
    33 sg:pub.10.1038/nri1030
    34 sg:pub.10.1038/nri2818
    35 sg:pub.10.1038/nri3384
    36 https://app.dimensions.ai/details/publication/pub.1083332955
    37 https://doi.org/10.1002/cyto.a.10072
    38 https://doi.org/10.1002/eji.200939922
    39 https://doi.org/10.1006/smim.1998.0136
    40 https://doi.org/10.1016/j.immuni.2004.06.020
    41 https://doi.org/10.1016/j.immuni.2008.04.022
    42 https://doi.org/10.1016/j.immuni.2009.08.001
    43 https://doi.org/10.1016/j.immuni.2009.08.006
    44 https://doi.org/10.1016/j.immuni.2010.08.013
    45 https://doi.org/10.1016/j.immuni.2011.04.018
    46 https://doi.org/10.1016/j.immuni.2011.08.001
    47 https://doi.org/10.1016/j.immuni.2012.06.003
    48 https://doi.org/10.1016/j.immuni.2012.06.011
    49 https://doi.org/10.1016/j.molimm.2013.03.006
    50 https://doi.org/10.1016/j.smim.2010.04.005
    51 https://doi.org/10.1016/s1074-7613(01)00097-8
    52 https://doi.org/10.1016/s1074-7613(02)00284-4
    53 https://doi.org/10.1073/pnas.0906988106
    54 https://doi.org/10.1073/pnas.1204327109
    55 https://doi.org/10.1073/pnas.81.13.4169
    56 https://doi.org/10.1073/pnas.93.18.9704
    57 https://doi.org/10.1084/jem.20101824
    58 https://doi.org/10.1084/jem.20110308
    59 https://doi.org/10.1084/jem.20111024
    60 https://doi.org/10.1096/fasebj.8.15.8001745
    61 https://doi.org/10.1111/j.1600-065x.1994.tb00894.x
    62 https://doi.org/10.1126/science.1069639
    63 https://doi.org/10.1126/science.1134301
    64 https://doi.org/10.1126/science.1192698
    65 https://doi.org/10.1126/science.1211250
    66 https://doi.org/10.1126/science.279.5357.1729
    67 https://doi.org/10.1146/annurev-immunol-020711-075053
    68 https://doi.org/10.1182/blood-2011-05-352732
    69 https://doi.org/10.1371/journal.pbio.1001589
    70 https://doi.org/10.4049/jimmunol.1002781
    71 https://doi.org/10.4049/jimmunol.177.7.4662
    72 https://doi.org/10.4049/jimmunol.180.3.1442
    73 https://doi.org/10.4049/jimmunol.181.3.1627
    74 https://doi.org/10.4049/jimmunol.181.5.3456
    75 https://doi.org/10.4049/jimmunol.181.9.5940
    76 schema:datePublished 2014-01
    77 schema:datePublishedReg 2014-01-01
    78 schema:description The subclassification of immunology into innate and adaptive immunity is challenged by innate-like T lymphocytes that use innate receptors to respond rapidly to stress despite expressing T cell antigen receptors (TCRs), a hallmark of adaptive immunity. In studies that explain how such cells can straddle innate and adaptive immunity, we found that signaling via antigen receptors, whose conventional role is to facilitate clonal T cell activation, was critical for the development of innate-like T cells but then was rapidly attenuated, which accommodated the cells' innate responsiveness. These findings permitted the identification of a previously unknown innate-like T cell subset and indicate that T cell hyporesponsiveness, a state traditionally linked to tolerance, may be fundamental to T cells entering the innate compartment and thereby providing lymphoid stress surveillance.
    79 schema:genre research_article
    80 schema:inLanguage en
    81 schema:isAccessibleForFree false
    82 schema:isPartOf N0c6c0a5238e04c11a1efc1f635d91da6
    83 N97d514249a7e42fcbad1047d46baacd4
    84 sg:journal.1022778
    85 schema:name Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness
    86 schema:pagination 80-87
    87 schema:productId N19b37db986b649498cea11eb049f8eba
    88 N7ffc1248e9844a1b92a58d7fee855650
    89 N9e7c61a612b64bb0bf4fda04d0d31924
    90 Nbc5ccf7b375a447a8a744cc7e7514102
    91 Ncefad75d54d14f3584c9dc73d39a3490
    92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037969525
    93 https://doi.org/10.1038/ni.2773
    94 schema:sdDatePublished 2019-04-10T16:32
    95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    96 schema:sdPublisher N3222d49d0a264b86b698b64851b5a337
    97 schema:url http://www.nature.com/articles/ni.2773
    98 sgo:license sg:explorer/license/
    99 sgo:sdDataset articles
    100 rdf:type schema:ScholarlyArticle
    101 N0a3eb7fe277c431ba253c149645aebec schema:name London Research Institute, Cancer Research UK, London, UK.
    102 rdf:type schema:Organization
    103 N0c6c0a5238e04c11a1efc1f635d91da6 schema:issueNumber 1
    104 rdf:type schema:PublicationIssue
    105 N11cb28ff9f704bd994e756dfe046ca27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Signal Transduction
    107 rdf:type schema:DefinedTerm
    108 N19b37db986b649498cea11eb049f8eba schema:name doi
    109 schema:value 10.1038/ni.2773
    110 rdf:type schema:PropertyValue
    111 N3222d49d0a264b86b698b64851b5a337 schema:name Springer Nature - SN SciGraph project
    112 rdf:type schema:Organization
    113 N3a583531468f43b78468e26d710e9ae7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Adaptive Immunity
    115 rdf:type schema:DefinedTerm
    116 N48752002f44f4e9da94a436d5b10ed8b rdf:first sg:person.0650365131.57
    117 rdf:rest rdf:nil
    118 N4bf0f7b1866b4875ae8ddc565e2f87c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name ZAP-70 Protein-Tyrosine Kinase
    120 rdf:type schema:DefinedTerm
    121 N56c4107086c745a390ef0b62b19e1770 rdf:first sg:person.01163477627.37
    122 rdf:rest Nd7f02a07457c427f985d1cc265c716f8
    123 N58c9e7cfca54437e80db4909ef7d144a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Green Fluorescent Proteins
    125 rdf:type schema:DefinedTerm
    126 N69737eec3d0949e8b27a9a9d842cc5a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Immunity, Innate
    128 rdf:type schema:DefinedTerm
    129 N79b857c063e74798b4736460f075c016 rdf:first sg:person.0622005006.12
    130 rdf:rest N48752002f44f4e9da94a436d5b10ed8b
    131 N7bfe905c72f54d6c98e2596387f29880 rdf:first sg:person.0627664041.11
    132 rdf:rest Nb0218a9ca34847c0aacc2d9fdbe7092c
    133 N7cbf76f62be04cdc979db275ea1d1056 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Interleukin-17
    135 rdf:type schema:DefinedTerm
    136 N7ffc1248e9844a1b92a58d7fee855650 schema:name pubmed_id
    137 schema:value 24241693
    138 rdf:type schema:PropertyValue
    139 N810c513c06d04ffa971381603f84d257 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Nuclear Receptor Subfamily 4, Group A, Member 1
    141 rdf:type schema:DefinedTerm
    142 N811add5ca7fa4aa080a33808a99bbfb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name T-Lymphocyte Subsets
    144 rdf:type schema:DefinedTerm
    145 N8983129d6b364c819993ed3906a4a319 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Mice, Inbred C57BL
    147 rdf:type schema:DefinedTerm
    148 N8fc6e8b6eb73462c94c69a4d9d807099 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Mice, Transgenic
    150 rdf:type schema:DefinedTerm
    151 N93fe205c848c44daa9d851705fa6cd44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Animals, Newborn
    153 rdf:type schema:DefinedTerm
    154 N97d514249a7e42fcbad1047d46baacd4 schema:volumeNumber 15
    155 rdf:type schema:PublicationVolume
    156 N9c1380011e52465d82c7a4c713fa7244 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Flow Cytometry
    158 rdf:type schema:DefinedTerm
    159 N9e7c61a612b64bb0bf4fda04d0d31924 schema:name readcube_id
    160 schema:value b4dfc487c5eea230ca76378230de11d462ede4ed6a60c2a80548fc7f8c60e565
    161 rdf:type schema:PropertyValue
    162 Nb0218a9ca34847c0aacc2d9fdbe7092c rdf:first sg:person.01156457215.48
    163 rdf:rest N79b857c063e74798b4736460f075c016
    164 Nb6cbc82932eb421e854d70ca16b0b9c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Receptors, Antigen, T-Cell
    166 rdf:type schema:DefinedTerm
    167 Nbc5ccf7b375a447a8a744cc7e7514102 schema:name dimensions_id
    168 schema:value pub.1037969525
    169 rdf:type schema:PropertyValue
    170 Nbc9002a2fc434505b1d208d5f9337db7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Animals
    172 rdf:type schema:DefinedTerm
    173 Nbe65eb1624d247cea5def501d829981b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Cells, Cultured
    175 rdf:type schema:DefinedTerm
    176 Ncefad75d54d14f3584c9dc73d39a3490 schema:name nlm_unique_id
    177 schema:value 100941354
    178 rdf:type schema:PropertyValue
    179 Nd7f02a07457c427f985d1cc265c716f8 rdf:first sg:person.01245362330.68
    180 rdf:rest N7bfe905c72f54d6c98e2596387f29880
    181 Ndcaa262270d44c8e8f8b77ac6dd8f711 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Mice, Inbred BALB C
    183 rdf:type schema:DefinedTerm
    184 Ne47fc0995419473690ce8e63cefc3884 schema:name London Research Institute, Cancer Research UK, London, UK.
    185 rdf:type schema:Organization
    186 Ne9940d3a0bf847999a474eaefd00813c rdf:first sg:person.01233175447.61
    187 rdf:rest N56c4107086c745a390ef0b62b19e1770
    188 Nf648982d23f64d8ab66e05baf6f663c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Receptors, Antigen, T-Cell, gamma-delta
    190 rdf:type schema:DefinedTerm
    191 Nfb0fb7a93e8b48e58c68ec106a64aac3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Mice
    193 rdf:type schema:DefinedTerm
    194 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    195 schema:name Medical and Health Sciences
    196 rdf:type schema:DefinedTerm
    197 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    198 schema:name Immunology
    199 rdf:type schema:DefinedTerm
    200 sg:journal.1022778 schema:issn 1529-2908
    201 1529-2916
    202 schema:name Nature Immunology
    203 rdf:type schema:Periodical
    204 sg:person.01156457215.48 schema:affiliation N0a3eb7fe277c431ba253c149645aebec
    205 schema:familyName Jandke
    206 schema:givenName Anett
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156457215.48
    208 rdf:type schema:Person
    209 sg:person.01163477627.37 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
    210 schema:familyName Turchinovich
    211 schema:givenName Gleb
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163477627.37
    213 rdf:type schema:Person
    214 sg:person.01233175447.61 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
    215 schema:familyName Wencker
    216 schema:givenName Melanie
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233175447.61
    218 rdf:type schema:Person
    219 sg:person.01245362330.68 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
    220 schema:familyName Di Marco Barros
    221 schema:givenName Rafael
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245362330.68
    223 rdf:type schema:Person
    224 sg:person.0622005006.12 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
    225 schema:familyName Cope
    226 schema:givenName Andrew
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622005006.12
    228 rdf:type schema:Person
    229 sg:person.0627664041.11 schema:affiliation Ne47fc0995419473690ce8e63cefc3884
    230 schema:familyName Deban
    231 schema:givenName Livija
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627664041.11
    233 rdf:type schema:Person
    234 sg:person.0650365131.57 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
    235 schema:familyName Hayday
    236 schema:givenName Adrian C
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650365131.57
    238 rdf:type schema:Person
    239 sg:pub.10.1038/343754a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046540947
    240 https://doi.org/10.1038/343754a0
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nature02119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030665392
    243 https://doi.org/10.1038/nature02119
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nature11311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004633454
    246 https://doi.org/10.1038/nature11311
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/ng.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048242401
    249 https://doi.org/10.1038/ng.108
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/ni.1717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034118078
    252 https://doi.org/10.1038/ni.1717
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/ni.2240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051558015
    255 https://doi.org/10.1038/ni.2240
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/ni.2292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032395563
    258 https://doi.org/10.1038/ni.2292
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/ni.2394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006653799
    261 https://doi.org/10.1038/ni.2394
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/ni1363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004728396
    264 https://doi.org/10.1038/ni1363
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/ni1400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053206259
    267 https://doi.org/10.1038/ni1400
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/ni1556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033450095
    270 https://doi.org/10.1038/ni1556
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/nri1030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003971889
    273 https://doi.org/10.1038/nri1030
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nri2818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005689832
    276 https://doi.org/10.1038/nri2818
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nri3384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010014687
    279 https://doi.org/10.1038/nri3384
    280 rdf:type schema:CreativeWork
    281 https://app.dimensions.ai/details/publication/pub.1083332955 schema:CreativeWork
    282 https://doi.org/10.1002/cyto.a.10072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022701923
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1002/eji.200939922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044104681
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1006/smim.1998.0136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009598447
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.immuni.2004.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051310437
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.immuni.2008.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010554640
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.immuni.2009.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048883448
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/j.immuni.2009.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016266241
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.immuni.2010.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029780340
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/j.immuni.2011.04.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028160472
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/j.immuni.2011.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033896817
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/j.immuni.2012.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044464899
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/j.immuni.2012.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032389822
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1016/j.molimm.2013.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004596303
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1016/j.smim.2010.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051756767
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/s1074-7613(01)00097-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043218364
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/s1074-7613(02)00284-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009133843
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1073/pnas.0906988106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040078409
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1073/pnas.1204327109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013271437
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1073/pnas.81.13.4169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051518687
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1073/pnas.93.18.9704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035251951
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1084/jem.20101824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031606481
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1084/jem.20110308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052758594
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1084/jem.20111024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016647099
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1096/fasebj.8.15.8001745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082603376
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1111/j.1600-065x.1994.tb00894.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052190626
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1126/science.1069639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002697167
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1126/science.1134301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010751773
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1126/science.1192698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024192657
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1126/science.1211250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062465505
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1126/science.279.5357.1729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062559933
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1146/annurev-immunol-020711-075053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050933093
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1182/blood-2011-05-352732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051393800
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1371/journal.pbio.1001589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022492607
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.4049/jimmunol.1002781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049604876
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.4049/jimmunol.177.7.4662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027260536
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.4049/jimmunol.180.3.1442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077593495
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.4049/jimmunol.181.3.1627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040775157
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.4049/jimmunol.181.5.3456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024746225
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.4049/jimmunol.181.9.5940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077798825
    359 rdf:type schema:CreativeWork
    360 https://www.grid.ac/institutes/grid.13097.3c schema:alternateName King's College London
    361 schema:name Centre for the Molecular and Cell Biology of Inflammation, King's College London, London, UK.
    362 London Research Institute, Cancer Research UK, London, UK.
    363 Peter Gorer Department of Immunobiology, King's College London, London, UK.
    364 rdf:type schema:Organization
    365 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
    366 schema:name London Research Institute, Cancer Research UK, London, UK.
    367 University College London, London, UK.
    368 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...