IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-10

AUTHORS

Ivan D Mascanfroni, Ada Yeste, Silvio M Vieira, Evan J Burns, Bonny Patel, Ido Sloma, Yan Wu, Lior Mayo, Rotem Ben-Hamo, Sol Efroni, Vijay K Kuchroo, Simon C Robson, Francisco J Quintana

ABSTRACT

Dendritic cells (DCs) control the balance between effector T cells and regulatory T cells in vivo. Hence, the study of DCs might identify mechanisms of disease pathogenesis and guide new therapeutic approaches for disorders mediated by the immune system. We found that interleukin 27 (IL-27) signaling in mouse DCs limited the generation of effector cells of the TH1 and TH17 subsets of helper T cells and the development of experimental autoimmune encephalomyelitis (EAE). The effects of IL-27 were mediated at least in part through induction of the immunoregulatory molecule CD39 in DCs. IL-27-induced CD39 decreased the extracellular concentration of ATP and downregulated nucleotide-dependent activation of the NLRP3 inflammasome. Finally, therapeutic vaccination with IL-27-conditioned DCs suppressed established relapsing-remitting EAE. Thus, IL-27 signaling in DCs limited pathogenic T cell responses and the development of autoimmunity. More... »

PAGES

1054-1063

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.2695

    DOI

    http://dx.doi.org/10.1038/ni.2695

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005433890

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23995234


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