IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-10

AUTHORS

Ivan D Mascanfroni, Ada Yeste, Silvio M Vieira, Evan J Burns, Bonny Patel, Ido Sloma, Yan Wu, Lior Mayo, Rotem Ben-Hamo, Sol Efroni, Vijay K Kuchroo, Simon C Robson, Francisco J Quintana

ABSTRACT

Dendritic cells (DCs) control the balance between effector T cells and regulatory T cells in vivo. Hence, the study of DCs might identify mechanisms of disease pathogenesis and guide new therapeutic approaches for disorders mediated by the immune system. We found that interleukin 27 (IL-27) signaling in mouse DCs limited the generation of effector cells of the TH1 and TH17 subsets of helper T cells and the development of experimental autoimmune encephalomyelitis (EAE). The effects of IL-27 were mediated at least in part through induction of the immunoregulatory molecule CD39 in DCs. IL-27-induced CD39 decreased the extracellular concentration of ATP and downregulated nucleotide-dependent activation of the NLRP3 inflammasome. Finally, therapeutic vaccination with IL-27-conditioned DCs suppressed established relapsing-remitting EAE. Thus, IL-27 signaling in DCs limited pathogenic T cell responses and the development of autoimmunity. More... »

PAGES

1054-1063

References to SciGraph publications

  • 2008-06. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants in NATURE
  • 2002-04. CD39 is the dominant Langerhans cell–associated ecto-NTPDase: Modulatory roles in inflammation and immune responsiveness in NATURE MEDICINE
  • 2005-03. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis in NATURE MEDICINE
  • 2005-03. Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis in NATURE MEDICINE
  • 2003-09. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis in NATURE BIOTECHNOLOGY
  • 2013-12. Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0 in BMC SYSTEMS BIOLOGY
  • 2010-09. Targeting dendritic cells to treat multiple sclerosis in NATURE REVIEWS NEUROLOGY
  • 2010-09. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27 in NATURE IMMUNOLOGY
  • 2006-09. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells in NATURE IMMUNOLOGY
  • 2006-09. Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system in NATURE IMMUNOLOGY
  • 2010-09. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells in NATURE IMMUNOLOGY
  • 2012-08. Aiolos promotes TH17 differentiation by directly silencing Il2 expression in NATURE IMMUNOLOGY
  • 2007-10. Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting in NATURE REVIEWS IMMUNOLOGY
  • 2007-12. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 in NATURE IMMUNOLOGY
  • 2012-11. A20: linking a complex regulator of ubiquitylation to immunity and human disease in NATURE REVIEWS IMMUNOLOGY
  • 2006-03. Cryopyrin activates the inflammasome in response to toxins and ATP in NATURE
  • 2007-12. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27–stimulated T cells in NATURE IMMUNOLOGY
  • 2008-05. Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor in NATURE
  • 2007-12. A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells in NATURE IMMUNOLOGY
  • 2007-02. CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ TH-17 cells in relapsing EAE in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.2695

    DOI

    http://dx.doi.org/10.1038/ni.2695

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005433890

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23995234


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