Origin of monocytes and macrophages in a committed progenitor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-08

AUTHORS

Jan Hettinger, David M Richards, Jenny Hansson, Melanie M Barra, Ann-Cathrin Joschko, Jeroen Krijgsveld, Markus Feuerer

ABSTRACT

Monocytes, macrophages and dendritic cells (DCs) are developmentally related regulators of the immune system that share the monocyte-macrophage DC progenitor (MDP) as a common precursor. Unlike differentiation into DCs, the distal pathways for differentiation into monocytes and monocyte-derived macrophages are not fully elucidated. We have now demonstrated the existence of a clonogenic, monocyte- and macrophage-restricted progenitor cell derived from the MDP. This progenitor was a Ly6C(+) proliferating cell present in the bone marrow and spleen that generated the major monocyte subsets and macrophages, but not DCs or neutrophils. By in-depth quantitative proteomics, we characterized changes in the proteome during monocyte differentiation, which provided insight into the molecular principles of developing monocytes, such as their functional maturation. Thus, we found that monocytes and macrophages were renewed independently of DCs from a committed progenitor. More... »

PAGES

821-830

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.2638

    DOI

    http://dx.doi.org/10.1038/ni.2638

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047954337

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23812096


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