IL-7 signaling must be intermittent, not continuous, during CD8+ T cell homeostasis to promote cell survival instead of cell death View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-02

AUTHORS

Motoko Y Kimura, Leonid A Pobezinsky, Terry I Guinter, Julien Thomas, Anthony Adams, Jung-Hyun Park, Xuguang Tai, Alfred Singer

ABSTRACT

The maintenance of naive CD8(+) T cells is necessary for lifelong immunocompetence but for unknown reasons requires signaling via both interleukin 7 (IL-7) and the T cell antigen receptor (TCR). We now report that naive CD8(+) T cells required IL-7 signaling to be intermittent, not continuous, because prolonged IL-7 signaling induced naive CD8(+) T cells to proliferate, produce interferon-γ (IFN-γ) and undergo IFN-γ-triggered cell death. Homeostatic engagement of the TCR interrupted IL-7 signaling and thereby supported the survival and quiescence of CD8(+) T cells. However, CD8(+) T cells with insufficient TCR affinity for self ligands received prolonged IL-7 signaling and died during homeostasis. In this study we identified regulation of the duration of IL-7 signaling by homeostatic engagement of the TCR as the basis for in vivo CD8(+) T cell homeostasis. More... »

PAGES

143

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni.2494

DOI

http://dx.doi.org/10.1038/ni.2494

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052081172

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23242416


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