Conformational states of the kinase Lck regulate clustering in early T cell signaling View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-01

AUTHORS

Jérémie Rossy, Dylan M Owen, David J Williamson, Zhengmin Yang, Katharina Gaus

ABSTRACT

Phosphorylation of the T cell antigen receptor (TCR) by the tyrosine kinase Lck is an essential step in the activation of T cells. Because Lck is constitutively active, spatial organization may regulate TCR signaling. Here we found that Lck distributions on the molecular level were controlled by the conformational states of Lck, with the open, active conformation inducing clustering and the closed, inactive conformation preventing clustering. In contrast, association with lipid domains and protein networks were not sufficient or necessary for Lck clustering. Conformation-driven Lck clustering was highly dynamic, so that TCR triggering resulted in Lck clusters that contained phosphorylated TCRs but excluded the phosphatase CD45. Our data suggest that Lck conformational states represent an intrinsic mechanism for the intermolecular organization of early T cell signaling. More... »

PAGES

82

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni.2488

DOI

http://dx.doi.org/10.1038/ni.2488

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037616905

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23202272


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