Transcription factor Foxp3 and its protein partners form a complex regulatory network View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-08-26

AUTHORS

Dipayan Rudra, Paul deRoos, Ashutosh Chaudhry, Rachel E Niec, Aaron Arvey, Robert M Samstein, Christina Leslie, Scott A Shaffer, David R Goodlett, Alexander Y Rudensky

ABSTRACT

The transcription factor Foxp3 is essential for the function of regulatory T cells. Rudensky and colleagues show Foxp3 participates in large protein complexes that regulate gene expression of many of these components in self-reinforcing networks.

PAGES

1010-1019

References to SciGraph publications

  • 2010-01-13. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate in NATURE
  • 2001-01. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 in NATURE GENETICS
  • 2007-02-02. Regulatory T cell development in the absence of functional Foxp3 in NATURE IMMUNOLOGY
  • 2009-05-03. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation in NATURE IMMUNOLOGY
  • 2007-10-07. Deacetylase inhibition promotes the generation and function of regulatory T cells in NATURE MEDICINE
  • 2007-01-14. Foxp3-dependent programme of regulatory T-cell differentiation in NATURE
  • 2008-07-15. FOXP3 and its partners: structural and biochemical insights into the regulation of FOXP3 activity in IMMUNOLOGIC RESEARCH
  • 2007-01-21. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells in NATURE
  • 2007-01-14. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 in NATURE IMMUNOLOGY
  • 2007-01-21. Foxp3 occupancy and regulation of key target genes during T-cell stimulation in NATURE
  • 2007-03-21. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1 in NATURE
  • 2009-09-20. Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells in NATURE IMMUNOLOGY
  • 2009-02-01. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses in NATURE
  • 2004-04-04. Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide–based retroviral vector in NATURE BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.2402

    DOI

    http://dx.doi.org/10.1038/ni.2402

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019681771

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22922362


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