Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-08-12

AUTHORS

Carrie R Willcox, Vincent Pitard, Sonia Netzer, Lionel Couzi, Mahboob Salim, Tobias Silberzahn, Jean-François Moreau, Adrian C Hayday, Benjamin E Willcox, Julie Déchanet-Merville

ABSTRACT

T cells bearing γδ T cell antigen receptors (TCRs) function in lymphoid stress surveillance. However, the contribution of γδ TCRs to such responses is unclear. Here we found that the TCR of a human V(γ)4V(δ)5 clone directly bound endothelial protein C receptor (EPCR), which allowed γδ T cells to recognize both endothelial cells targeted by cytomegalovirus and epithelial tumors. EPCR is a major histocompatibility complex-like molecule that binds lipids analogously to the antigen-presenting molecule CD1d. However, the V(γ)4V(δ)5 TCR bound EPCR independently of lipids, in an antibody-like way. Moreover, the recognition of target cells by γδ T cells required a multimolecular stress signature composed of EPCR and costimulatory ligand(s). Our results demonstrate how a γδ TCR mediates recognition of broadly stressed human cells by engaging a stress-regulated self antigen. More... »

PAGES

872

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni.2394

DOI

http://dx.doi.org/10.1038/ni.2394

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006653799

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22885985


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