Aiolos promotes TH17 differentiation by directly silencing Il2 expression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-08

AUTHORS

Francisco J Quintana, Hulin Jin, Evan J Burns, Meghan Nadeau, Ada Yeste, Deepak Kumar, Manu Rangachari, Chen Zhu, Sheng Xiao, John Seavitt, Katia Georgopoulos, Vijay K Kuchroo

ABSTRACT

CD4(+) interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) are instrumental in the immune response to pathogens. However, an overactive T(H)17 response results in tissue inflammation and autoimmunity, and therefore it is important to identify the molecular mechanisms that control the development of T(H)17 cells. IL-2 suppresses such development, but how IL-2 production is actively suppressed during T(H)7 differentiation is not understood. Here we report that under T(H)17-polarizing conditions, the transcription factors STAT3 and AhR upregulated the expression of Aiolos, a member of the Ikaros family of transcription factors. Using Aiolos-deficient mice, we demonstrated that Aiolos silenced the Il2 locus, promoting T(H)17 differentiation in vitro and in vivo. Thus, we have identified a module in the transcriptional program of T(H)17 cells that actively limits IL-2 production and promotes their differentiation. More... »

PAGES

770

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.2363

    DOI

    http://dx.doi.org/10.1038/ni.2363

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009732439

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22751139


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