Transcription factor RORα is critical for nuocyte development View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01-22

AUTHORS

See Heng Wong, Jennifer A Walker, Helen E Jolin, Lesley F Drynan, Emily Hams, Ana Camelo, Jillian L Barlow, Daniel R Neill, Veera Panova, Ute Koch, Freddy Radtke, Clare S Hardman, You Yi Hwang, Padraic G Fallon, Andrew N J McKenzie

ABSTRACT

Nuocytes are innate cells with critical roles during infection with parasitic worms. McKenzie and colleagues show that nuocytes differentiate from common lymphoid progenitors and require IL-7, IL-33, Notch and RORα for development.

PAGES

229-236

References to SciGraph publications

  • 2011-09-11. Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161 in NATURE IMMUNOLOGY
  • 2010-11-28. The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling in NATURE IMMUNOLOGY
  • 2008-11-02. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity in NATURE
  • 2008-01. Launching the T-cell-lineage developmental programme in NATURE REVIEWS IMMUNOLOGY
  • 1996-02. Disruption of the nuclear hormone receptor RORα in staggerer mice in NATURE
  • 2009-12-20. Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells in NATURE
  • 2008-04. Adult T-cell progenitors retain myeloid potential in NATURE
  • 2004-02-25. Notch regulation of lymphocyte development and function in NATURE IMMUNOLOGY
  • 2008-11-23. Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin in NATURE IMMUNOLOGY
  • 2010-04-01. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity in NATURE
  • 2011-09-11. Notch signaling is necessary for adult, but not fetal, development of RORγt+ innate lymphoid cells in NATURE IMMUNOLOGY
  • 2011-05-29. Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity in NATURE IMMUNOLOGY
  • 2010-04-15. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology in NATURE
  • 2008-11-23. RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells in NATURE IMMUNOLOGY
  • 2008-11-23. Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.2208

    DOI

    http://dx.doi.org/10.1038/ni.2208

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005144013

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22267218


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