Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01

AUTHORS

Trevor Siggers, Abraham B Chang, Ana Teixeira, Daniel Wong, Kevin J Williams, Bilal Ahmed, Jiannis Ragoussis, Irina A Udalova, Stephen T Smale, Martha L Bulyk

ABSTRACT

The unique DNA-binding properties of distinct NF-κB dimers influence the selective regulation of NF-κB target genes. To more thoroughly investigate these dimer-specific differences, we combined protein-binding microarrays and surface plasmon resonance to evaluate DNA sites recognized by eight different NF-κB dimers. We observed three distinct binding-specificity classes and clarified mechanisms by which dimers might regulate distinct sets of genes. We identified many new nontraditional NF-κB binding site (κB site) sequences and highlight the plasticity of NF-κB dimers in recognizing κB sites with a single consensus half-site. This study provides a database that can be used in efforts to identify NF-κB target sites and uncover gene regulatory circuitry. More... »

PAGES

95

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni.2151

DOI

http://dx.doi.org/10.1038/ni.2151

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013900878

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22101729


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