Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-12

AUTHORS

Sascha Rutz, Rajkumar Noubade, Céline Eidenschenk, Naruhisa Ota, Wenwen Zeng, Yan Zheng, Jason Hackney, Jiabing Ding, Harinder Singh, Wenjun Ouyang

ABSTRACT

Interleukin 22 (IL-22), which is produced by cells of the T(H)17 subset of helper T cells and other leukocytes, not only enhances proinflammatory innate defense mechanisms in epithelial cells but also provides crucial protection to tissues from damage caused by inflammation and infection. In T(H)17 cells, transforming growth factor-β (TGF-β) regulates IL-22 and IL-17 differently. IL-6 alone induces T cells to produce only IL-22, whereas the combination of IL-6 and high concentrations of TGF-β results in the production of IL-17 but not IL-22 by T cells. Here we identify the transcription factor c-Maf, which is induced by TGF-β, as a downstream repressor of Il22. We found that c-Maf bound to the Il22 promoter and was both necessary and sufficient for the TGF-β-dependent suppression of IL-22 production in T(H)17 cells. More... »

PAGES

1238

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.2134

    DOI

    http://dx.doi.org/10.1038/ni.2134

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019856387

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22001828


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