Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-12

AUTHORS

Sascha Rutz, Rajkumar Noubade, Céline Eidenschenk, Naruhisa Ota, Wenwen Zeng, Yan Zheng, Jason Hackney, Jiabing Ding, Harinder Singh, Wenjun Ouyang

ABSTRACT

Interleukin 22 (IL-22), which is produced by cells of the T(H)17 subset of helper T cells and other leukocytes, not only enhances proinflammatory innate defense mechanisms in epithelial cells but also provides crucial protection to tissues from damage caused by inflammation and infection. In T(H)17 cells, transforming growth factor-β (TGF-β) regulates IL-22 and IL-17 differently. IL-6 alone induces T cells to produce only IL-22, whereas the combination of IL-6 and high concentrations of TGF-β results in the production of IL-17 but not IL-22 by T cells. Here we identify the transcription factor c-Maf, which is induced by TGF-β, as a downstream repressor of Il22. We found that c-Maf bound to the Il22 promoter and was both necessary and sufficient for the TGF-β-dependent suppression of IL-22 production in T(H)17 cells. More... »

PAGES

1238

References to SciGraph publications

  • 2008-05. Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor in NATURE
  • 2007-02. Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis in NATURE
  • 2006-05. Transforming growth factor-β induces development of the TH17 lineage in NATURE
  • 2009-07. The AP-1 transcription factor Batf controls TH17 differentiation in NATURE
  • 2007-12. TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology in NATURE IMMUNOLOGY
  • 2010-10. Generation of pathogenic TH17 cells in the absence of TGF-β signalling in NATURE
  • 2002-08. c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction in ONCOGENE
  • 2006-05. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells in NATURE
  • 2009-08. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells in NATURE IMMUNOLOGY
  • 2008-05. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins in NATURE
  • 2009-08. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells in NATURE IMMUNOLOGY
  • 2010-09. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27 in NATURE IMMUNOLOGY
  • 2008-12. Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset in NATURE IMMUNOLOGY
  • 2007-07. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells in NATURE
  • 2008-03. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens in NATURE MEDICINE
  • 2008-03. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.2134

    DOI

    http://dx.doi.org/10.1038/ni.2134

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019856387

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22001828


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Base Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Basic-Leucine Zipper Transcription Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Binding Sites", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HEK293 Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred BALB C", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nuclear Receptor Subfamily 1, Group F, Member 3", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nucleotide Motifs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Promoter Regions, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins c-maf", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Aryl Hydrocarbon", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Th17 Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transforming Growth Factor beta", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Roche (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418158.1", 
              "name": [
                "Department of Immunology, Genentech, South San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rutz", 
            "givenName": "Sascha", 
            "id": "sg:person.01242022037.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242022037.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Roche (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418158.1", 
              "name": [
                "Department of Immunology, Genentech, South San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Noubade", 
            "givenName": "Rajkumar", 
            "id": "sg:person.01151010403.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151010403.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Roche (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418158.1", 
              "name": [
                "Department of Immunology, Genentech, South San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eidenschenk", 
            "givenName": "C\u00e9line", 
            "id": "sg:person.01153234056.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153234056.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Roche (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418158.1", 
              "name": [
                "Department of Immunology, Genentech, South San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ota", 
            "givenName": "Naruhisa", 
            "id": "sg:person.01067037176.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067037176.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Roche (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418158.1", 
              "name": [
                "Department of Immunology, Genentech, South San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zeng", 
            "givenName": "Wenwen", 
            "id": "sg:person.013744340477.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013744340477.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Roche (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418158.1", 
              "name": [
                "Department of Immunology, Genentech, South San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zheng", 
            "givenName": "Yan", 
            "id": "sg:person.0675006270.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675006270.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Roche (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418158.1", 
              "name": [
                "Bioinformatics & Computational Biology, Genentech, South San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hackney", 
            "givenName": "Jason", 
            "id": "sg:person.01007162776.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007162776.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Roche (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418158.1", 
              "name": [
                "Department of Immunology, Genentech, South San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ding", 
            "givenName": "Jiabing", 
            "id": "sg:person.01124160511.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124160511.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Roche (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418158.1", 
              "name": [
                "Department of Immunology, Genentech, South San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Singh", 
            "givenName": "Harinder", 
            "id": "sg:person.01054753166.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054753166.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Roche (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418158.1", 
              "name": [
                "Department of Immunology, Genentech, South San Francisco, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ouyang", 
            "givenName": "Wenjun", 
            "id": "sg:person.0642223276.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642223276.95"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1002/eji.200838331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000319778"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001933444", 
              "https://doi.org/10.1038/ni1539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkh334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003138545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.174.6.3484", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006201514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007842569", 
              "https://doi.org/10.1038/nature05505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007842569", 
              "https://doi.org/10.1038/nature05505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2006.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009201806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.06.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010253104"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1710", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010575772", 
              "https://doi.org/10.1038/nm1710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1720", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012378283", 
              "https://doi.org/10.1038/nm1720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014700103", 
              "https://doi.org/10.1038/ni.1767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014700103", 
              "https://doi.org/10.1038/ni.1767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m000921200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016093588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019012655", 
              "https://doi.org/10.1038/ni.1659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81299-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020092418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200738075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020148913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.174.5.2720", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021085397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.0909639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021455735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.14.1.700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022510410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06881", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024002249", 
              "https://doi.org/10.1038/nature06881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.0902464", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024685535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06880", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025127308", 
              "https://doi.org/10.1038/nature06880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025981728", 
              "https://doi.org/10.1038/nature09447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025981728", 
              "https://doi.org/10.1038/nature09447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.22.012703.104622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026487544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1770", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028876950", 
              "https://doi.org/10.1038/ni.1770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1770", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028876950", 
              "https://doi.org/10.1038/ni.1770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2007.11.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030088683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205642", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031327761", 
              "https://doi.org/10.1038/sj.onc.1205642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205642", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031327761", 
              "https://doi.org/10.1038/sj.onc.1205642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20061308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033164618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2004.07.102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033686561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.0900123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034572957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1912", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035443919", 
              "https://doi.org/10.1038/ni.1912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037247321", 
              "https://doi.org/10.1038/nature04753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037247321", 
              "https://doi.org/10.1038/nature04753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037682433", 
              "https://doi.org/10.1038/nature05969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.03.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037791327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038119253", 
              "https://doi.org/10.1038/nature08114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038119253", 
              "https://doi.org/10.1038/nature08114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2007.07.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043060777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coph.2009.04.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043581609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.18.5.2729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043723519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80073-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044138158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.07.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046724496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.0901233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047471901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2133.2008.08769.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047809592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cytogfr.2010.10.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047985118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20030152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048335036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.164.4.1814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048868097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.194.4.519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049165263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20092054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049413261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.intimp.2004.01.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050890531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.021908.132710", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053134590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20081438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053601738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3001500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062686809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3001500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062686809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.23861/ejbm20072347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077582945"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-12", 
        "datePublishedReg": "2011-12-01", 
        "description": "Interleukin 22 (IL-22), which is produced by cells of the T(H)17 subset of helper T cells and other leukocytes, not only enhances proinflammatory innate defense mechanisms in epithelial cells but also provides crucial protection to tissues from damage caused by inflammation and infection. In T(H)17 cells, transforming growth factor-\u03b2 (TGF-\u03b2) regulates IL-22 and IL-17 differently. IL-6 alone induces T cells to produce only IL-22, whereas the combination of IL-6 and high concentrations of TGF-\u03b2 results in the production of IL-17 but not IL-22 by T cells. Here we identify the transcription factor c-Maf, which is induced by TGF-\u03b2, as a downstream repressor of Il22. We found that c-Maf bound to the Il22 promoter and was both necessary and sufficient for the TGF-\u03b2-dependent suppression of IL-22 production in T(H)17 cells.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ni.2134", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1022778", 
            "issn": [
              "1529-2908", 
              "1529-2916"
            ], 
            "name": "Nature Immunology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "12", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "12"
          }
        ], 
        "name": "Transcription factor c-Maf mediates the TGF-\u03b2-dependent suppression of IL-22 production in TH17 cells", 
        "pagination": "1238", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "5e9b44aad6e74b3db560ad67c48fb40a2392495ea2b44d9dd5997b8e3112786e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22001828"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100941354"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ni.2134"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1019856387"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ni.2134", 
          "https://app.dimensions.ai/details/publication/pub.1019856387"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:46", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000435.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/ni.2134"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ni.2134'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni.2134'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ni.2134'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni.2134'


     

    This table displays all metadata directly associated to this object as RDF triples.

    382 TRIPLES      21 PREDICATES      100 URIs      41 LITERALS      29 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ni.2134 schema:about N022014af61124795a7e1ff0d823de16f
    2 N091325a9b4df4e3f90b602737e9ed5a8
    3 N09faf4659d594d36a026c6e627e16e46
    4 N0fd68d4db57949cba30bb6f2e39dc6f6
    5 N1bc542c4629b4950b36bd9b397fe5fc1
    6 N202fdf6185cd4145957de873e25c1062
    7 N2b654885ce4649f2844b99bccfe4ec8f
    8 N437e987b142c4150be1379d847aa29fe
    9 N43bf744c20d247f4a7090e13080d2383
    10 N4616101e48804e368e48e36543b3ffa3
    11 N63ae270b5851487da43afe12f75e3ab7
    12 N7c33502d73a744e9ae24129064388f6b
    13 N86ef9ed55129459f9d71ca871a6488d8
    14 N8bd9c3e7c5df43ef949c2085018a0107
    15 N8c3e1a56b4ae4438be4f783f5208efdc
    16 N9b7c134c9e92400891cce9eac796c681
    17 Nbd17e5dbe04e49ccbae4c7e91ea2bf7e
    18 Ncdf377bb5faa4feb82e27f18cd9b11fe
    19 Nd9e9cbc8b2044cb99f1f1ad0956a3db3
    20 Nf4b39bab6707468aa98efa5835d21ba4
    21 anzsrc-for:11
    22 anzsrc-for:1107
    23 schema:author N23a47c5557124f82a46118f05881d2c1
    24 schema:citation sg:pub.10.1038/nature04753
    25 sg:pub.10.1038/nature04754
    26 sg:pub.10.1038/nature05505
    27 sg:pub.10.1038/nature05969
    28 sg:pub.10.1038/nature06880
    29 sg:pub.10.1038/nature06881
    30 sg:pub.10.1038/nature08114
    31 sg:pub.10.1038/nature09447
    32 sg:pub.10.1038/ni.1659
    33 sg:pub.10.1038/ni.1767
    34 sg:pub.10.1038/ni.1770
    35 sg:pub.10.1038/ni.1912
    36 sg:pub.10.1038/ni1539
    37 sg:pub.10.1038/nm1710
    38 sg:pub.10.1038/nm1720
    39 sg:pub.10.1038/sj.onc.1205642
    40 https://doi.org/10.1002/eji.200738075
    41 https://doi.org/10.1002/eji.200838331
    42 https://doi.org/10.1016/j.cell.2006.07.035
    43 https://doi.org/10.1016/j.coph.2009.04.008
    44 https://doi.org/10.1016/j.cytogfr.2010.10.007
    45 https://doi.org/10.1016/j.immuni.2006.01.001
    46 https://doi.org/10.1016/j.immuni.2007.07.023
    47 https://doi.org/10.1016/j.immuni.2007.11.016
    48 https://doi.org/10.1016/j.immuni.2008.03.004
    49 https://doi.org/10.1016/j.immuni.2009.06.008
    50 https://doi.org/10.1016/j.intimp.2004.01.016
    51 https://doi.org/10.1016/j.jmb.2004.07.102
    52 https://doi.org/10.1016/s0092-8674(00)81299-4
    53 https://doi.org/10.1016/s1074-7613(00)80073-4
    54 https://doi.org/10.1074/jbc.m000921200
    55 https://doi.org/10.1084/jem.194.4.519
    56 https://doi.org/10.1084/jem.20030152
    57 https://doi.org/10.1084/jem.20061308
    58 https://doi.org/10.1084/jem.20081438
    59 https://doi.org/10.1084/jem.20092054
    60 https://doi.org/10.1093/nar/gkh334
    61 https://doi.org/10.1111/j.1365-2133.2008.08769.x
    62 https://doi.org/10.1126/scitranslmed.3001500
    63 https://doi.org/10.1128/mcb.14.1.700
    64 https://doi.org/10.1128/mcb.18.5.2729
    65 https://doi.org/10.1146/annurev.immunol.021908.132710
    66 https://doi.org/10.1146/annurev.immunol.22.012703.104622
    67 https://doi.org/10.1189/jlb.0909639
    68 https://doi.org/10.23861/ejbm20072347
    69 https://doi.org/10.4049/jimmunol.0900123
    70 https://doi.org/10.4049/jimmunol.0901233
    71 https://doi.org/10.4049/jimmunol.0902464
    72 https://doi.org/10.4049/jimmunol.164.4.1814
    73 https://doi.org/10.4049/jimmunol.174.5.2720
    74 https://doi.org/10.4049/jimmunol.174.6.3484
    75 schema:datePublished 2011-12
    76 schema:datePublishedReg 2011-12-01
    77 schema:description Interleukin 22 (IL-22), which is produced by cells of the T(H)17 subset of helper T cells and other leukocytes, not only enhances proinflammatory innate defense mechanisms in epithelial cells but also provides crucial protection to tissues from damage caused by inflammation and infection. In T(H)17 cells, transforming growth factor-β (TGF-β) regulates IL-22 and IL-17 differently. IL-6 alone induces T cells to produce only IL-22, whereas the combination of IL-6 and high concentrations of TGF-β results in the production of IL-17 but not IL-22 by T cells. Here we identify the transcription factor c-Maf, which is induced by TGF-β, as a downstream repressor of Il22. We found that c-Maf bound to the Il22 promoter and was both necessary and sufficient for the TGF-β-dependent suppression of IL-22 production in T(H)17 cells.
    78 schema:genre research_article
    79 schema:inLanguage en
    80 schema:isAccessibleForFree false
    81 schema:isPartOf N35e4c06765df43ad94568d06feba9d82
    82 N68ca9e05795a46a184c6b566006b2c75
    83 sg:journal.1022778
    84 schema:name Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells
    85 schema:pagination 1238
    86 schema:productId N350fc56622e44e6394699aa191334701
    87 N57b14294bab54b02a6ce29fe2e7d37e3
    88 Na72a658d7fee47c2a03783bafd63b70d
    89 Nc8786d4b790a4d94824d2d8bddfa1883
    90 Nd9532731fab1469a8f3465a9974a4d9f
    91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019856387
    92 https://doi.org/10.1038/ni.2134
    93 schema:sdDatePublished 2019-04-10T19:46
    94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    95 schema:sdPublisher N19d325bb91b9429785007d9a4432dccd
    96 schema:url https://www.nature.com/articles/ni.2134
    97 sgo:license sg:explorer/license/
    98 sgo:sdDataset articles
    99 rdf:type schema:ScholarlyArticle
    100 N022014af61124795a7e1ff0d823de16f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Th17 Cells
    102 rdf:type schema:DefinedTerm
    103 N091325a9b4df4e3f90b602737e9ed5a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Cells, Cultured
    105 rdf:type schema:DefinedTerm
    106 N09faf4659d594d36a026c6e627e16e46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name HEK293 Cells
    108 rdf:type schema:DefinedTerm
    109 N0d0b7ce925f544719202cb4256e72767 rdf:first sg:person.01151010403.56
    110 rdf:rest Ned1fc55c0dd646be974f208aff27c1e2
    111 N0fd68d4db57949cba30bb6f2e39dc6f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Interleukins
    113 rdf:type schema:DefinedTerm
    114 N106fb7c1291a4559b5829e16a7d3f870 rdf:first sg:person.01007162776.28
    115 rdf:rest Ne34c94d82ab24d279946bc53c27b418c
    116 N19d325bb91b9429785007d9a4432dccd schema:name Springer Nature - SN SciGraph project
    117 rdf:type schema:Organization
    118 N1bc542c4629b4950b36bd9b397fe5fc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Gene Expression Regulation
    120 rdf:type schema:DefinedTerm
    121 N202fdf6185cd4145957de873e25c1062 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Transcription, Genetic
    123 rdf:type schema:DefinedTerm
    124 N222bb7afb70449dbafd4f33d34ce3e4e rdf:first sg:person.01054753166.41
    125 rdf:rest Nd5f737f09de94f6c8041fbeac9cd40c8
    126 N23a47c5557124f82a46118f05881d2c1 rdf:first sg:person.01242022037.84
    127 rdf:rest N0d0b7ce925f544719202cb4256e72767
    128 N2b654885ce4649f2844b99bccfe4ec8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Promoter Regions, Genetic
    130 rdf:type schema:DefinedTerm
    131 N350fc56622e44e6394699aa191334701 schema:name pubmed_id
    132 schema:value 22001828
    133 rdf:type schema:PropertyValue
    134 N35e4c06765df43ad94568d06feba9d82 schema:volumeNumber 12
    135 rdf:type schema:PublicationVolume
    136 N437e987b142c4150be1379d847aa29fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Mice
    138 rdf:type schema:DefinedTerm
    139 N43bf744c20d247f4a7090e13080d2383 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Receptors, Aryl Hydrocarbon
    141 rdf:type schema:DefinedTerm
    142 N4616101e48804e368e48e36543b3ffa3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Nucleotide Motifs
    144 rdf:type schema:DefinedTerm
    145 N57b14294bab54b02a6ce29fe2e7d37e3 schema:name readcube_id
    146 schema:value 5e9b44aad6e74b3db560ad67c48fb40a2392495ea2b44d9dd5997b8e3112786e
    147 rdf:type schema:PropertyValue
    148 N63ae270b5851487da43afe12f75e3ab7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Base Sequence
    150 rdf:type schema:DefinedTerm
    151 N68ca9e05795a46a184c6b566006b2c75 schema:issueNumber 12
    152 rdf:type schema:PublicationIssue
    153 N7c33502d73a744e9ae24129064388f6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Transforming Growth Factor beta
    155 rdf:type schema:DefinedTerm
    156 N86ef9ed55129459f9d71ca871a6488d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Proto-Oncogene Proteins c-maf
    158 rdf:type schema:DefinedTerm
    159 N8bd9c3e7c5df43ef949c2085018a0107 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Nuclear Receptor Subfamily 1, Group F, Member 3
    161 rdf:type schema:DefinedTerm
    162 N8c3e1a56b4ae4438be4f783f5208efdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Mice, Inbred BALB C
    164 rdf:type schema:DefinedTerm
    165 N9b7c134c9e92400891cce9eac796c681 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Gene Expression Profiling
    167 rdf:type schema:DefinedTerm
    168 Na72a658d7fee47c2a03783bafd63b70d schema:name doi
    169 schema:value 10.1038/ni.2134
    170 rdf:type schema:PropertyValue
    171 Nbd17e5dbe04e49ccbae4c7e91ea2bf7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Binding Sites
    173 rdf:type schema:DefinedTerm
    174 Nc8786d4b790a4d94824d2d8bddfa1883 schema:name nlm_unique_id
    175 schema:value 100941354
    176 rdf:type schema:PropertyValue
    177 Nca4c46cafa584d01a0e15316d4f95377 rdf:first sg:person.01067037176.22
    178 rdf:rest Ndf581d035b2948c6b20c406054389305
    179 Ncdf377bb5faa4feb82e27f18cd9b11fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Humans
    181 rdf:type schema:DefinedTerm
    182 Nd5f737f09de94f6c8041fbeac9cd40c8 rdf:first sg:person.0642223276.95
    183 rdf:rest rdf:nil
    184 Nd9532731fab1469a8f3465a9974a4d9f schema:name dimensions_id
    185 schema:value pub.1019856387
    186 rdf:type schema:PropertyValue
    187 Nd9e9cbc8b2044cb99f1f1ad0956a3db3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Animals
    189 rdf:type schema:DefinedTerm
    190 Ndf581d035b2948c6b20c406054389305 rdf:first sg:person.013744340477.30
    191 rdf:rest Nff7dd06e5949403cbb6743d9fb08a0ee
    192 Ne34c94d82ab24d279946bc53c27b418c rdf:first sg:person.01124160511.32
    193 rdf:rest N222bb7afb70449dbafd4f33d34ce3e4e
    194 Ned1fc55c0dd646be974f208aff27c1e2 rdf:first sg:person.01153234056.86
    195 rdf:rest Nca4c46cafa584d01a0e15316d4f95377
    196 Nf4b39bab6707468aa98efa5835d21ba4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Basic-Leucine Zipper Transcription Factors
    198 rdf:type schema:DefinedTerm
    199 Nff7dd06e5949403cbb6743d9fb08a0ee rdf:first sg:person.0675006270.74
    200 rdf:rest N106fb7c1291a4559b5829e16a7d3f870
    201 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    202 schema:name Medical and Health Sciences
    203 rdf:type schema:DefinedTerm
    204 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    205 schema:name Immunology
    206 rdf:type schema:DefinedTerm
    207 sg:journal.1022778 schema:issn 1529-2908
    208 1529-2916
    209 schema:name Nature Immunology
    210 rdf:type schema:Periodical
    211 sg:person.01007162776.28 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
    212 schema:familyName Hackney
    213 schema:givenName Jason
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007162776.28
    215 rdf:type schema:Person
    216 sg:person.01054753166.41 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
    217 schema:familyName Singh
    218 schema:givenName Harinder
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054753166.41
    220 rdf:type schema:Person
    221 sg:person.01067037176.22 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
    222 schema:familyName Ota
    223 schema:givenName Naruhisa
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067037176.22
    225 rdf:type schema:Person
    226 sg:person.01124160511.32 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
    227 schema:familyName Ding
    228 schema:givenName Jiabing
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124160511.32
    230 rdf:type schema:Person
    231 sg:person.01151010403.56 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
    232 schema:familyName Noubade
    233 schema:givenName Rajkumar
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151010403.56
    235 rdf:type schema:Person
    236 sg:person.01153234056.86 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
    237 schema:familyName Eidenschenk
    238 schema:givenName Céline
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153234056.86
    240 rdf:type schema:Person
    241 sg:person.01242022037.84 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
    242 schema:familyName Rutz
    243 schema:givenName Sascha
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242022037.84
    245 rdf:type schema:Person
    246 sg:person.013744340477.30 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
    247 schema:familyName Zeng
    248 schema:givenName Wenwen
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013744340477.30
    250 rdf:type schema:Person
    251 sg:person.0642223276.95 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
    252 schema:familyName Ouyang
    253 schema:givenName Wenjun
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642223276.95
    255 rdf:type schema:Person
    256 sg:person.0675006270.74 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
    257 schema:familyName Zheng
    258 schema:givenName Yan
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675006270.74
    260 rdf:type schema:Person
    261 sg:pub.10.1038/nature04753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037247321
    262 https://doi.org/10.1038/nature04753
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/nature04754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043278106
    265 https://doi.org/10.1038/nature04754
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/nature05505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007842569
    268 https://doi.org/10.1038/nature05505
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/nature05969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037682433
    271 https://doi.org/10.1038/nature05969
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/nature06880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025127308
    274 https://doi.org/10.1038/nature06880
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/nature06881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024002249
    277 https://doi.org/10.1038/nature06881
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/nature08114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038119253
    280 https://doi.org/10.1038/nature08114
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/nature09447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025981728
    283 https://doi.org/10.1038/nature09447
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/ni.1659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019012655
    286 https://doi.org/10.1038/ni.1659
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/ni.1767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014700103
    289 https://doi.org/10.1038/ni.1767
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/ni.1770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028876950
    292 https://doi.org/10.1038/ni.1770
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/ni.1912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035443919
    295 https://doi.org/10.1038/ni.1912
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/ni1539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001933444
    298 https://doi.org/10.1038/ni1539
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/nm1710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010575772
    301 https://doi.org/10.1038/nm1710
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/nm1720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012378283
    304 https://doi.org/10.1038/nm1720
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/sj.onc.1205642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031327761
    307 https://doi.org/10.1038/sj.onc.1205642
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1002/eji.200738075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020148913
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1002/eji.200838331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000319778
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.cell.2006.07.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046724496
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.coph.2009.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043581609
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.cytogfr.2010.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047985118
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.immuni.2006.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009201806
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.immuni.2007.07.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043060777
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/j.immuni.2007.11.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030088683
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/j.immuni.2008.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037791327
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/j.immuni.2009.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010253104
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/j.intimp.2004.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050890531
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/j.jmb.2004.07.102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033686561
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/s0092-8674(00)81299-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020092418
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/s1074-7613(00)80073-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044138158
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1074/jbc.m000921200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016093588
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1084/jem.194.4.519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049165263
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1084/jem.20030152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048335036
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1084/jem.20061308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033164618
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1084/jem.20081438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053601738
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1084/jem.20092054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049413261
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1093/nar/gkh334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003138545
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1111/j.1365-2133.2008.08769.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047809592
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1126/scitranslmed.3001500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062686809
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1128/mcb.14.1.700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022510410
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1128/mcb.18.5.2729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043723519
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1146/annurev.immunol.021908.132710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053134590
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1146/annurev.immunol.22.012703.104622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026487544
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1189/jlb.0909639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021455735
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.23861/ejbm20072347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077582945
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.4049/jimmunol.0900123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034572957
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.4049/jimmunol.0901233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047471901
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.4049/jimmunol.0902464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024685535
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.4049/jimmunol.164.4.1814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048868097
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.4049/jimmunol.174.5.2720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021085397
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.4049/jimmunol.174.6.3484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006201514
    378 rdf:type schema:CreativeWork
    379 https://www.grid.ac/institutes/grid.418158.1 schema:alternateName Roche (United States)
    380 schema:name Bioinformatics & Computational Biology, Genentech, South San Francisco, California, USA.
    381 Department of Immunology, Genentech, South San Francisco, California, USA.
    382 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...