Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-09

AUTHORS

Marc Beyer, Yasser Thabet, Roman-Ulrich Müller, Timothy Sadlon, Sabine Classen, Katharina Lahl, Samik Basu, Xuyu Zhou, Samantha L Bailey-Bucktrout, Wolfgang Krebs, Eva A Schönfeld, Jan Böttcher, Tatiana Golovina, Christian T Mayer, Andrea Hofmann, Daniel Sommer, Svenja Debey-Pascher, Elmar Endl, Andreas Limmer, Keli L Hippen, Bruce R Blazar, Robert Balderas, Thomas Quast, Andreas Waha, Günter Mayer, Michael Famulok, Percy A Knolle, Claudia Wickenhauser, Waldemar Kolanus, Bernhard Schermer, Jeffrey A Bluestone, Simon C Barry, Tim Sparwasser, James L Riley, Joachim L Schultze

ABSTRACT

Regulatory T cells (T(reg) cells) are essential for self-tolerance and immune homeostasis. Lack of effector T cell (T(eff) cell) function and gain of suppressive activity by T(reg) cells are dependent on the transcriptional program induced by Foxp3. Here we report that repression of SATB1, a genome organizer that regulates chromatin structure and gene expression, was crucial for the phenotype and function of T(reg) cells. Foxp3, acting as a transcriptional repressor, directly suppressed the SATB1 locus and indirectly suppressed it through the induction of microRNAs that bound the SATB1 3' untranslated region. Release of SATB1 from the control of Foxp3 in T(reg) cells caused loss of suppressive function, establishment of transcriptional T(eff) cell programs and induction of T(eff) cell cytokines. Our data support the proposal that inhibition of SATB1-mediated modulation of global chromatin remodeling is pivotal for maintaining T(reg) cell functionality. More... »

PAGES

898

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.2084

    DOI

    http://dx.doi.org/10.1038/ni.2084

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002295466

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21841785


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    626 schema:name Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.
    627 rdf:type schema:Organization
    628 https://www.grid.ac/institutes/grid.6190.e schema:alternateName University of Cologne
    629 schema:name Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.
    630 Renal Division, Department of Medicine and Centre for Molecular Medicine, University of Cologne, Cologne, Germany.
    631 rdf:type schema:Organization
     




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