Ontology type: schema:ScholarlyArticle
2011-07-19
AUTHORSYinon Ben-Neriah, Michael Karin
ABSTRACTInflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-κB in inflammation and cancer. Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-κB has a confounding role in certain tumors. Understanding the activity and function of NF-κB in the context of tumorigenesis is critical for its successful taming, an important challenge for modern cancer biology. More... »
PAGES715-723
http://scigraph.springernature.com/pub.10.1038/ni.2060
DOIhttp://dx.doi.org/10.1038/ni.2060
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