Inflammation meets cancer, with NF-κB as the matchmaker View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-07-19

AUTHORS

Yinon Ben-Neriah, Michael Karin

ABSTRACT

Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-κB in inflammation and cancer. Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-κB has a confounding role in certain tumors. Understanding the activity and function of NF-κB in the context of tumorigenesis is critical for its successful taming, an important challenge for modern cancer biology. More... »

PAGES

715-723

References to SciGraph publications

  • 2004-08-25. NF-κB functions as a tumour promoter in inflammation-associated cancer in NATURE
  • 2003-11-13. An inhibitor of IκB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice in INFLAMMATION RESEARCH
  • 2001-12. Possible new role for NF-κB in the resolution of inflammation in NATURE MEDICINE
  • 2007-01-01. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment in NATURE REVIEWS IMMUNOLOGY
  • 2005-09-20. NF-κB: linking inflammation and immunity to cancer development and progression in NATURE REVIEWS IMMUNOLOGY
  • 1974-03. Epithelial proliferation and morphogenesis of hyperplastic adenomatous and villous polyps of the human colon in VIRCHOWS ARCHIV A PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
  • 2010-03. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer in NATURE
  • 2010-09-20. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm in NATURE IMMUNOLOGY
  • 2009-05-03. Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma in NATURE
  • 2000-05. High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-κB activation in NATURE MEDICINE
  • 2011-06-19. Return to homeostasis: downregulation of NF-κB responses in NATURE IMMUNOLOGY
  • 2009-04. The cancer genome in NATURE
  • 2011-07-19. Hierarchies of NF-κB target-gene regulation in NATURE IMMUNOLOGY
  • 2003. The Rel/NF-κB/IκB Signal Transduction Pathway and Cancer in SIGNAL TRANSDUCTION IN CANCER
  • 1992-09. The candidate oncoprotein Bcl-3 is an antagonist of pSO/NF-κB-mediated inhibition in NATURE
  • 2006-03-29. A loss-of-function RNA interference screen for molecular targets in cancer in NATURE
  • 2005-04. Nuclear factor-κB inhibitors as sensitizers to anticancer drugs in NATURE REVIEWS CANCER
  • 2011-02-16. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling in NATURE
  • 2011-02-16. CKIα ablation highlights a critical role for p53 in invasiveness control in NATURE
  • 2002-04. NF-κB in cancer: from innocent bystander to major culprit in NATURE REVIEWS CANCER
  • 2010-12-19. IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ in NATURE IMMUNOLOGY
  • 2007-05-30. Gene-specific control of inflammation by TLR-induced chromatin modifications in NATURE
  • 2003-02. NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia in NATURE
  • 2008-12-17. Crypt stem cells as the cells-of-origin of intestinal cancer in NATURE
  • 2003-01-06. Activation of the transcription factor NF-κB in Schwann cells is required for peripheral myelin formation in NATURE NEUROSCIENCE
  • 2007-04-29. p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway in NATURE GENETICS
  • 2002-12. Inflammation and cancer in NATURE
  • 2010-03-03. Cancer and Inflammation: Implications for Pharmacology and Therapeutics in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2007-03-14. Epithelial NEMO links innate immunity to chronic intestinal inflammation in NATURE
  • 2003-04. NF-κB in Mammary Gland Development and Breast Cancer in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • 2009-11. Regulation of tissue homeostasis by NF-κB signalling: implications for inflammatory diseases in NATURE REVIEWS IMMUNOLOGY
  • 1998-12. Identification of the receptor component of the IκBα–ubiquitin ligase in NATURE
  • 2010-07-06. Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-κB activity in myeloma cells in MOLECULAR CANCER
  • 2010-09-29. RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis in NATURE
  • 2010-11-28. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts in NATURE
  • 2010-08. The Amphimedon queenslandica genome and the evolution of animal complexity in NATURE
  • 2006-05-24. Nuclear factor-κB in cancer development and progression in NATURE
  • 2007-03-18. Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin in NATURE
  • 2010-12-22. Oncogenically active MYD88 mutations in human lymphoma in NATURE
  • 2009-11. STATs in cancer inflammation and immunity: a leading role for STAT3 in NATURE REVIEWS CANCER
  • 2003-04-07. The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion in NATURE MEDICINE
  • 2008-12-01. Here, there, everywhere? in NATURE
  • 2010-05-21. Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa in BMC BIOLOGY
  • 2011-03-23. Initial genome sequencing and analysis of multiple myeloma in NATURE
  • 2010-09-29. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer in NATURE
  • 1996-09. Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF–κB abrogates established experimental colitis in mice in NATURE MEDICINE
  • 2011-03-23. FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR in NATURE
  • 2010-09-28. Involvement of activation-induced cytidine deaminase in the development of colitis-associated colorectal cancers in JOURNAL OF GASTROENTEROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.2060

    DOI

    http://dx.doi.org/10.1038/ni.2060

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045118814

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21772280


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunity, Innate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inflammation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "NF-kappa B", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Lautenberg Center for Immunology, Institute for Medical Research-Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel", 
              "id": "http://www.grid.ac/institutes/grid.9619.7", 
              "name": [
                "Lautenberg Center for Immunology, Institute for Medical Research-Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ben-Neriah", 
            "givenName": "Yinon", 
            "id": "sg:person.01123165765.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123165765.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacology and Cancer Center, Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, La Jolla, California, USA.", 
              "id": "http://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Department of Pharmacology and Cancer Center, Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, La Jolla, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Karin", 
            "givenName": "Michael", 
            "id": "sg:person.0706540600.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706540600.87"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature08782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013990990", 
              "https://doi.org/10.1038/nature08782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02924", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042163603", 
              "https://doi.org/10.1038/nature02924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/456581a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033101878", 
              "https://doi.org/10.1038/456581a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027634754", 
              "https://doi.org/10.1038/nature05656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043364117", 
              "https://doi.org/10.1038/nature04870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn995", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004743482", 
              "https://doi.org/10.1038/nn995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004744235", 
              "https://doi.org/10.1038/nature01283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/0-306-48158-8_10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020593566", 
              "https://doi.org/10.1007/0-306-48158-8_10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022123078", 
              "https://doi.org/10.1038/nrc2734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024581782", 
              "https://doi.org/10.1038/nrc780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2655", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033551392", 
              "https://doi.org/10.1038/nri2655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047923424", 
              "https://doi.org/10.1038/ng2033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09707", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031128276", 
              "https://doi.org/10.1038/nature09707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022516418", 
              "https://doi.org/10.1038/ni.1976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0996-998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014827861", 
              "https://doi.org/10.1038/nm0996-998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020963310", 
              "https://doi.org/10.1038/nature07602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-010-0326-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050330919", 
              "https://doi.org/10.1007/s00535-010-0326-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030733290", 
              "https://doi.org/10.1038/nature05698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07968", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047607151", 
              "https://doi.org/10.1038/nature07968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/75057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040989563", 
              "https://doi.org/10.1038/75057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032966632", 
              "https://doi.org/10.1038/nature05836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033506792", 
              "https://doi.org/10.1038/nature09870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/25159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040632613", 
              "https://doi.org/10.1038/25159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-9-176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012381365", 
              "https://doi.org/10.1186/1476-4598-9-176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00011-003-1206-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023919345", 
              "https://doi.org/10.1007/s00011-003-1206-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09837", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007161398", 
              "https://doi.org/10.1038/nature09837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm849", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040348344", 
              "https://doi.org/10.1038/nm849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1937", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042773705", 
              "https://doi.org/10.1038/ni.1937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039295960", 
              "https://doi.org/10.1038/nature09387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1741-7007-8-66", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000808139", 
              "https://doi.org/10.1186/1741-7007-8-66"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01230856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025308127", 
              "https://doi.org/10.1007/bf01230856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004829095", 
              "https://doi.org/10.1038/nature07943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019336134", 
              "https://doi.org/10.1038/nature01322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002056529", 
              "https://doi.org/10.1038/nature09671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023010419", 
              "https://doi.org/10.1038/ni.2070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028032153", 
              "https://doi.org/10.1038/nature09495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040307540", 
              "https://doi.org/10.1038/ni.2055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003293768", 
              "https://doi.org/10.1038/nrc1588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09637", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030684957", 
              "https://doi.org/10.1038/nature09637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042005558", 
              "https://doi.org/10.1038/nature09201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04687", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000514179", 
              "https://doi.org/10.1038/nature04687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/359339a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053158066", 
              "https://doi.org/10.1038/359339a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011428149", 
              "https://doi.org/10.1038/nri1703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1995", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052092567", 
              "https://doi.org/10.1038/nri1995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09673", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016270819", 
              "https://doi.org/10.1038/nature09673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1201-1291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042511547", 
              "https://doi.org/10.1038/nm1201-1291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.2009.312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022908421", 
              "https://doi.org/10.1038/clpt.2009.312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1025905008934", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021972748", 
              "https://doi.org/10.1023/a:1025905008934"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-07-19", 
        "datePublishedReg": "2011-07-19", 
        "description": "Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-\u03baB in inflammation and cancer. Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-\u03baB has a confounding role in certain tumors. Understanding the activity and function of NF-\u03baB in the context of tumorigenesis is critical for its successful taming, an important challenge for modern cancer biology.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/ni.2060", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1022778", 
            "issn": [
              "1529-2908", 
              "1529-2916"
            ], 
            "name": "Nature Immunology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "12"
          }
        ], 
        "keywords": [
          "context of tumorigenesis", 
          "modern cancer biology", 
          "NF-\u03baB", 
          "transcription factor NF-\u03baB", 
          "evolutionary relationships", 
          "tumor-promoting role", 
          "factor NF-\u03baB", 
          "chronic human diseases", 
          "human diseases", 
          "cancer biology", 
          "types of cancer", 
          "major cofactor", 
          "certain tumors", 
          "protective response", 
          "biology", 
          "cofactor", 
          "inflammation", 
          "cancer", 
          "tumorigenesis", 
          "role", 
          "confounding role", 
          "function", 
          "pathogenesis", 
          "tumors", 
          "disease", 
          "activity", 
          "response", 
          "important challenge", 
          "matchmaker", 
          "types", 
          "relationship", 
          "context", 
          "challenges", 
          "taming"
        ], 
        "name": "Inflammation meets cancer, with NF-\u03baB as the matchmaker", 
        "pagination": "715-723", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1045118814"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ni.2060"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21772280"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ni.2060", 
          "https://app.dimensions.ai/details/publication/pub.1045118814"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-20T07:26", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_530.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/ni.2060"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ni.2060'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni.2060'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ni.2060'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni.2060'


     

    This table displays all metadata directly associated to this object as RDF triples.

    322 TRIPLES      22 PREDICATES      114 URIs      58 LITERALS      13 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ni.2060 schema:about N0f39ba43c4664badbf98ea3f1e50ce67
    2 N76956c65d9c142399b62ccfb50f1266d
    3 N921e3d771e1a4685b5aa77f60b48facb
    4 Nc5f952dbf3ff4a36bc4a1ec547e7265a
    5 Nc6672439113b4874a8faa5a70262afb6
    6 Nd2c990c0ff2f4842b9b77c1be48fcaed
    7 anzsrc-for:11
    8 anzsrc-for:1107
    9 schema:author Nc084cdd71a94467eb860db07db0108fd
    10 schema:citation sg:pub.10.1007/0-306-48158-8_10
    11 sg:pub.10.1007/bf01230856
    12 sg:pub.10.1007/s00011-003-1206-4
    13 sg:pub.10.1007/s00535-010-0326-1
    14 sg:pub.10.1023/a:1025905008934
    15 sg:pub.10.1038/25159
    16 sg:pub.10.1038/359339a0
    17 sg:pub.10.1038/456581a
    18 sg:pub.10.1038/75057
    19 sg:pub.10.1038/clpt.2009.312
    20 sg:pub.10.1038/nature01283
    21 sg:pub.10.1038/nature01322
    22 sg:pub.10.1038/nature02924
    23 sg:pub.10.1038/nature04687
    24 sg:pub.10.1038/nature04870
    25 sg:pub.10.1038/nature05656
    26 sg:pub.10.1038/nature05698
    27 sg:pub.10.1038/nature05836
    28 sg:pub.10.1038/nature07602
    29 sg:pub.10.1038/nature07943
    30 sg:pub.10.1038/nature07968
    31 sg:pub.10.1038/nature08782
    32 sg:pub.10.1038/nature09201
    33 sg:pub.10.1038/nature09387
    34 sg:pub.10.1038/nature09495
    35 sg:pub.10.1038/nature09637
    36 sg:pub.10.1038/nature09671
    37 sg:pub.10.1038/nature09673
    38 sg:pub.10.1038/nature09707
    39 sg:pub.10.1038/nature09837
    40 sg:pub.10.1038/nature09870
    41 sg:pub.10.1038/ng2033
    42 sg:pub.10.1038/ni.1937
    43 sg:pub.10.1038/ni.1976
    44 sg:pub.10.1038/ni.2055
    45 sg:pub.10.1038/ni.2070
    46 sg:pub.10.1038/nm0996-998
    47 sg:pub.10.1038/nm1201-1291
    48 sg:pub.10.1038/nm849
    49 sg:pub.10.1038/nn995
    50 sg:pub.10.1038/nrc1588
    51 sg:pub.10.1038/nrc2734
    52 sg:pub.10.1038/nrc780
    53 sg:pub.10.1038/nri1703
    54 sg:pub.10.1038/nri1995
    55 sg:pub.10.1038/nri2655
    56 sg:pub.10.1186/1476-4598-9-176
    57 sg:pub.10.1186/1741-7007-8-66
    58 schema:datePublished 2011-07-19
    59 schema:datePublishedReg 2011-07-19
    60 schema:description Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-κB in inflammation and cancer. Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-κB has a confounding role in certain tumors. Understanding the activity and function of NF-κB in the context of tumorigenesis is critical for its successful taming, an important challenge for modern cancer biology.
    61 schema:genre article
    62 schema:inLanguage en
    63 schema:isAccessibleForFree false
    64 schema:isPartOf N5594deefb57d45bfa651bc0f14f0e081
    65 N68150f3d076e4b32a3217c675f07c2a3
    66 sg:journal.1022778
    67 schema:keywords NF-κB
    68 activity
    69 biology
    70 cancer
    71 cancer biology
    72 certain tumors
    73 challenges
    74 chronic human diseases
    75 cofactor
    76 confounding role
    77 context
    78 context of tumorigenesis
    79 disease
    80 evolutionary relationships
    81 factor NF-κB
    82 function
    83 human diseases
    84 important challenge
    85 inflammation
    86 major cofactor
    87 matchmaker
    88 modern cancer biology
    89 pathogenesis
    90 protective response
    91 relationship
    92 response
    93 role
    94 taming
    95 transcription factor NF-κB
    96 tumor-promoting role
    97 tumorigenesis
    98 tumors
    99 types
    100 types of cancer
    101 schema:name Inflammation meets cancer, with NF-κB as the matchmaker
    102 schema:pagination 715-723
    103 schema:productId N0825ccc29a3e4a87a193f7fd4c38be9f
    104 Nb537d641aef54af3a6566475c267d583
    105 Nf6c4feea6932418dbb0dfbc4bc5cc962
    106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045118814
    107 https://doi.org/10.1038/ni.2060
    108 schema:sdDatePublished 2022-05-20T07:26
    109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    110 schema:sdPublisher N3fa5f312e4d14c869e793ffad5f72b9e
    111 schema:url https://doi.org/10.1038/ni.2060
    112 sgo:license sg:explorer/license/
    113 sgo:sdDataset articles
    114 rdf:type schema:ScholarlyArticle
    115 N0825ccc29a3e4a87a193f7fd4c38be9f schema:name dimensions_id
    116 schema:value pub.1045118814
    117 rdf:type schema:PropertyValue
    118 N0f39ba43c4664badbf98ea3f1e50ce67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Animals
    120 rdf:type schema:DefinedTerm
    121 N3fa5f312e4d14c869e793ffad5f72b9e schema:name Springer Nature - SN SciGraph project
    122 rdf:type schema:Organization
    123 N5594deefb57d45bfa651bc0f14f0e081 schema:issueNumber 8
    124 rdf:type schema:PublicationIssue
    125 N68150f3d076e4b32a3217c675f07c2a3 schema:volumeNumber 12
    126 rdf:type schema:PublicationVolume
    127 N76956c65d9c142399b62ccfb50f1266d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Neoplasms
    129 rdf:type schema:DefinedTerm
    130 N921e3d771e1a4685b5aa77f60b48facb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name NF-kappa B
    132 rdf:type schema:DefinedTerm
    133 Nb537d641aef54af3a6566475c267d583 schema:name doi
    134 schema:value 10.1038/ni.2060
    135 rdf:type schema:PropertyValue
    136 Nc084cdd71a94467eb860db07db0108fd rdf:first sg:person.01123165765.15
    137 rdf:rest Nf114bee0e9b54ed1a5d57536315c07ab
    138 Nc5f952dbf3ff4a36bc4a1ec547e7265a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Inflammation
    140 rdf:type schema:DefinedTerm
    141 Nc6672439113b4874a8faa5a70262afb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Humans
    143 rdf:type schema:DefinedTerm
    144 Nd2c990c0ff2f4842b9b77c1be48fcaed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Immunity, Innate
    146 rdf:type schema:DefinedTerm
    147 Nf114bee0e9b54ed1a5d57536315c07ab rdf:first sg:person.0706540600.87
    148 rdf:rest rdf:nil
    149 Nf6c4feea6932418dbb0dfbc4bc5cc962 schema:name pubmed_id
    150 schema:value 21772280
    151 rdf:type schema:PropertyValue
    152 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    153 schema:name Medical and Health Sciences
    154 rdf:type schema:DefinedTerm
    155 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    156 schema:name Immunology
    157 rdf:type schema:DefinedTerm
    158 sg:journal.1022778 schema:issn 1529-2908
    159 1529-2916
    160 schema:name Nature Immunology
    161 schema:publisher Springer Nature
    162 rdf:type schema:Periodical
    163 sg:person.01123165765.15 schema:affiliation grid-institutes:grid.9619.7
    164 schema:familyName Ben-Neriah
    165 schema:givenName Yinon
    166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123165765.15
    167 rdf:type schema:Person
    168 sg:person.0706540600.87 schema:affiliation grid-institutes:grid.266100.3
    169 schema:familyName Karin
    170 schema:givenName Michael
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706540600.87
    172 rdf:type schema:Person
    173 sg:pub.10.1007/0-306-48158-8_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020593566
    174 https://doi.org/10.1007/0-306-48158-8_10
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1007/bf01230856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025308127
    177 https://doi.org/10.1007/bf01230856
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1007/s00011-003-1206-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023919345
    180 https://doi.org/10.1007/s00011-003-1206-4
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1007/s00535-010-0326-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050330919
    183 https://doi.org/10.1007/s00535-010-0326-1
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1023/a:1025905008934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021972748
    186 https://doi.org/10.1023/a:1025905008934
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1038/25159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040632613
    189 https://doi.org/10.1038/25159
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1038/359339a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053158066
    192 https://doi.org/10.1038/359339a0
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1038/456581a schema:sameAs https://app.dimensions.ai/details/publication/pub.1033101878
    195 https://doi.org/10.1038/456581a
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1038/75057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040989563
    198 https://doi.org/10.1038/75057
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/clpt.2009.312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022908421
    201 https://doi.org/10.1038/clpt.2009.312
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/nature01283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004744235
    204 https://doi.org/10.1038/nature01283
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/nature01322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019336134
    207 https://doi.org/10.1038/nature01322
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/nature02924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042163603
    210 https://doi.org/10.1038/nature02924
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/nature04687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000514179
    213 https://doi.org/10.1038/nature04687
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/nature04870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043364117
    216 https://doi.org/10.1038/nature04870
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/nature05656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027634754
    219 https://doi.org/10.1038/nature05656
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/nature05698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030733290
    222 https://doi.org/10.1038/nature05698
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/nature05836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032966632
    225 https://doi.org/10.1038/nature05836
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/nature07602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020963310
    228 https://doi.org/10.1038/nature07602
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/nature07943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004829095
    231 https://doi.org/10.1038/nature07943
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nature07968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047607151
    234 https://doi.org/10.1038/nature07968
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nature08782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013990990
    237 https://doi.org/10.1038/nature08782
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nature09201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042005558
    240 https://doi.org/10.1038/nature09201
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nature09387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039295960
    243 https://doi.org/10.1038/nature09387
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nature09495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028032153
    246 https://doi.org/10.1038/nature09495
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nature09637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030684957
    249 https://doi.org/10.1038/nature09637
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/nature09671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002056529
    252 https://doi.org/10.1038/nature09671
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nature09673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016270819
    255 https://doi.org/10.1038/nature09673
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/nature09707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031128276
    258 https://doi.org/10.1038/nature09707
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/nature09837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007161398
    261 https://doi.org/10.1038/nature09837
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/nature09870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033506792
    264 https://doi.org/10.1038/nature09870
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/ng2033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047923424
    267 https://doi.org/10.1038/ng2033
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/ni.1937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042773705
    270 https://doi.org/10.1038/ni.1937
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/ni.1976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022516418
    273 https://doi.org/10.1038/ni.1976
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/ni.2055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040307540
    276 https://doi.org/10.1038/ni.2055
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/ni.2070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023010419
    279 https://doi.org/10.1038/ni.2070
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/nm0996-998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014827861
    282 https://doi.org/10.1038/nm0996-998
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nm1201-1291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042511547
    285 https://doi.org/10.1038/nm1201-1291
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nm849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040348344
    288 https://doi.org/10.1038/nm849
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/nn995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004743482
    291 https://doi.org/10.1038/nn995
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/nrc1588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003293768
    294 https://doi.org/10.1038/nrc1588
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/nrc2734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022123078
    297 https://doi.org/10.1038/nrc2734
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/nrc780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024581782
    300 https://doi.org/10.1038/nrc780
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/nri1703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011428149
    303 https://doi.org/10.1038/nri1703
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/nri1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052092567
    306 https://doi.org/10.1038/nri1995
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/nri2655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033551392
    309 https://doi.org/10.1038/nri2655
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1186/1476-4598-9-176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012381365
    312 https://doi.org/10.1186/1476-4598-9-176
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1186/1741-7007-8-66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000808139
    315 https://doi.org/10.1186/1741-7007-8-66
    316 rdf:type schema:CreativeWork
    317 grid-institutes:grid.266100.3 schema:alternateName Department of Pharmacology and Cancer Center, Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, La Jolla, California, USA.
    318 schema:name Department of Pharmacology and Cancer Center, Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, La Jolla, California, USA.
    319 rdf:type schema:Organization
    320 grid-institutes:grid.9619.7 schema:alternateName Lautenberg Center for Immunology, Institute for Medical Research-Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel
    321 schema:name Lautenberg Center for Immunology, Institute for Medical Research-Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel
    322 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...