The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-09

AUTHORS

Lionel Apetoh, Francisco J Quintana, Caroline Pot, Nicole Joller, Sheng Xiao, Deepak Kumar, Evan J Burns, David H Sherr, Howard L Weiner, Vijay K Kuchroo

ABSTRACT

Type 1 regulatory T cells (Tr1 cells ) that produce interleukin 10 (IL-10) are instrumental in the prevention of tissue inflammation, autoimmunity and graft-versus-host disease. The transcription factor c-Maf is essential for the induction of IL-10 by Tr1 cells, but the molecular mechanisms that lead to the development of these cells remain unclear. Here we show that the ligand-activated transcription factor aryl hydrocarbon receptor (AhR), which was induced by IL-27, acted in synergy with c-Maf to promote the development of Tr1 cells. After T cell activation under Tr1-skewing conditions, the AhR bound to c-Maf and promoted transactivation of the Il10 and Il21 promoters, which resulted in the generation of Tr1 cells and the amelioration of experimental autoimmune encephalomyelitis. Manipulating AhR signaling could therefore be beneficial in the resolution of excessive inflammatory responses. More... »

PAGES

854

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.1912

    DOI

    http://dx.doi.org/10.1038/ni.1912

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035443919

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20676095


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