TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-01

AUTHORS

Björn F Lillemeier, Manuel A Mörtelmaier, Martin B Forstner, Johannes B Huppa, Jay T Groves, Mark M Davis

ABSTRACT

The organization and dynamics of receptors and other molecules in the plasma membrane are not well understood. Here we analyzed the spatio-temporal dynamics of T cell antigen receptor (TCR) complexes and linker for activation of T cells (Lat), a key adaptor molecule in the TCR signaling pathway, in T cell membranes using high-speed photoactivated localization microscopy, dual-color fluorescence cross-correlation spectroscopy and transmission electron microscopy. In quiescent T cells, both molecules existed in separate membrane domains (protein islands), and these domains concatenated after T cell activation. These concatemers were identical to signaling microclusters, a prominent hallmark of T cell activation. This separation versus physical juxtapositioning of receptor domains and domains containing downstream signaling molecules in quiescent versus activated T cells may be a general feature of plasma membrane-associated signal transduction. More... »

PAGES

90-96

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni.1832

DOI

http://dx.doi.org/10.1038/ni.1832

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019926285

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20010844


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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

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