Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-01

AUTHORS

Ping-Hui Tseng, Atsushi Matsuzawa, Weizhou Zhang, Takashi Mino, Dario A A Vignali, Michael Karin

ABSTRACT

Balanced production of type I interferons and proinflammatory cytokines after engagement of Toll-like receptors (TLRs), which signal through adaptors containing a Toll-interleukin 1 receptor (TIR) domain, such as MyD88 and TRIF, has been proposed to control the pathogenesis of autoimmune disease and tumor responses to inflammation. Here we show that TRAF3, a ubiquitin ligase that interacts with both MyD88 and TRIF, regulated the production of interferon and proinflammatory cytokines in different ways. Degradative ubiquitination of TRAF3 during MyD88-dependent TLR signaling was essential for the activation of mitogen-activated protein kinases (MAPKs) and production of inflammatory cytokines. In contrast, TRIF-dependent signaling triggered noncanonical TRAF3 self-ubiquitination that activated the interferon response. Inhibition of degradative ubiquitination of TRAF3 prevented the expression of all proinflammatory cytokines without affecting the interferon response. More... »

PAGES

70-75

References to SciGraph publications

  • 2008-12. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling in NATURE IMMUNOLOGY
  • 2007-05. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling in NATURE REVIEWS IMMUNOLOGY
  • 2005-04. IAPs, RINGs and ubiquitylation in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2005. Toll-Like Receptors: Linking Innate and Adaptive Immunity in MECHANISMS OF LYMPHOCYTE ACTIVATION AND IMMUNE REGULATION X
  • 2006-09. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling in NATURE IMMUNOLOGY
  • 2005-11. Essential function for the kinase TAK1 in innate and adaptive immune responses in NATURE IMMUNOLOGY
  • 2005-04. IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation in NATURE
  • 2006-01. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6 in NATURE
  • 2002-03. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2 in NATURE
  • 2006-01. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response in NATURE
  • 2003-11. TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway in NATURE IMMUNOLOGY
  • 2007. Characteristics and Biological Functions of TRAF6 in TNF RECEPTOR ASSOCIATED FACTORS (TRAFS)
  • 2007. Ubiquitination and TRAF signaling in TNF RECEPTOR ASSOCIATED FACTORS (TRAFS)
  • 2003-08. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling in NATURE
  • 2001-09. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction in NATURE
  • 2008-04. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β in NATURE IMMUNOLOGY
  • 2004-07. Toll-like receptor signalling in NATURE REVIEWS IMMUNOLOGY
  • 2001-09. TIRAP: an adapter molecule in the Toll signaling pathway in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.1819

    DOI

    http://dx.doi.org/10.1038/ni.1819

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011969709

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19898473


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adaptor Proteins, Vesicular Transport", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoblotting", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inflammation Mediators", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inhibitor of Apoptosis Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interferon Type I", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lipopolysaccharides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Macrophages", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitogen-Activated Protein Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myeloid Differentiation Factor 88", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphorylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Binding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reverse Transcriptase Polymerase Chain Reaction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "TNF Receptor-Associated Factor 3", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "TNF Receptor-Associated Factor 6", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Toll-Like Receptor 4", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ubiquitination", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "National Yang Ming University", 
              "id": "https://www.grid.ac/institutes/grid.260770.4", 
              "name": [
                "Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, USA.", 
                "Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tseng", 
            "givenName": "Ping-Hui", 
            "id": "sg:person.01057655622.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057655622.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, USA.", 
                "Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsuzawa", 
            "givenName": "Atsushi", 
            "id": "sg:person.01012667130.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012667130.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Diego", 
              "id": "https://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Weizhou", 
            "id": "sg:person.01311621713.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311621713.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Diego", 
              "id": "https://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mino", 
            "givenName": "Takashi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Jude Children's Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.240871.8", 
              "name": [
                "Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vignali", 
            "givenName": "Dario A A", 
            "id": "sg:person.0711622372.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711622372.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Diego", 
              "id": "https://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Karin", 
            "givenName": "Michael", 
            "id": "sg:person.0706540600.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706540600.87"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nri2079", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005511542", 
              "https://doi.org/10.1038/nri2079"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2005.08.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006857288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2005.08.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006857288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0000788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007384798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2007.08.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008093277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009798136", 
              "https://doi.org/10.1038/ni1367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009798136", 
              "https://doi.org/10.1038/ni1367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011667818", 
              "https://doi.org/10.1038/nature04369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011667818", 
              "https://doi.org/10.1038/nature04369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011667818", 
              "https://doi.org/10.1038/nature04369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1157340", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011843378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35092578", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012150444", 
              "https://doi.org/10.1038/35092578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35092578", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012150444", 
              "https://doi.org/10.1038/35092578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015350802", 
              "https://doi.org/10.1038/nature04374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015350802", 
              "https://doi.org/10.1038/nature04374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015350802", 
              "https://doi.org/10.1038/nature04374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016882586", 
              "https://doi.org/10.1038/ni1255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016882586", 
              "https://doi.org/10.1038/ni1255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017708694", 
              "https://doi.org/10.1038/ni.1678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/0-387-24180-9_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017918564", 
              "https://doi.org/10.1007/0-387-24180-9_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-291x(77)90249-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019181050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-70630-6_7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020499530", 
              "https://doi.org/10.1007/978-0-387-70630-6_7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-70630-6_7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020499530", 
              "https://doi.org/10.1007/978-0-387-70630-6_7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023753307", 
              "https://doi.org/10.1038/nri1391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023753307", 
              "https://doi.org/10.1038/nri1391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-70630-6_6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025684039", 
              "https://doi.org/10.1007/978-0-387-70630-6_6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-70630-6_6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025684039", 
              "https://doi.org/10.1007/978-0-387-70630-6_6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-70630-6_6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025684039", 
              "https://doi.org/10.1007/978-0-387-70630-6_6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2443.2001.00426.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025945490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2007.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025985820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci31537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027236338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.169.12.6668", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027946692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m104994200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029462603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)00521-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029513979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030777085", 
              "https://doi.org/10.1038/ni986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030777085", 
              "https://doi.org/10.1038/ni986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03491", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031720585", 
              "https://doi.org/10.1038/nature03491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03491", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031720585", 
              "https://doi.org/10.1038/nature03491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032010638", 
              "https://doi.org/10.1038/nrm1621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032010638", 
              "https://doi.org/10.1038/nrm1621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1569", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032207157", 
              "https://doi.org/10.1038/ni1569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2006.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035479622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m303451200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035774951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0901-835", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037156244", 
              "https://doi.org/10.1038/ni0901-835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0901-835", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037156244", 
              "https://doi.org/10.1038/ni0901-835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m609503200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037225474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.02.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037898031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.smim.2006.12.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041216221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(02)00390-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043398905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80086-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044146057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(00)80136-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044317166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2006.08.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044397575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.r700009200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044883374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2004.08.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046593922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/416345a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047676603", 
              "https://doi.org/10.1038/416345a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/416345a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047676603", 
              "https://doi.org/10.1038/416345a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050980808", 
              "https://doi.org/10.1038/nature01889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050980808", 
              "https://doi.org/10.1038/nature01889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.111.5.1811", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052111633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mi.3.8.466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062438406"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1062438406", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mi.3.8.466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062438406"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1098231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062449652"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-01", 
        "datePublishedReg": "2010-01-01", 
        "description": "Balanced production of type I interferons and proinflammatory cytokines after engagement of Toll-like receptors (TLRs), which signal through adaptors containing a Toll-interleukin 1 receptor (TIR) domain, such as MyD88 and TRIF, has been proposed to control the pathogenesis of autoimmune disease and tumor responses to inflammation. Here we show that TRAF3, a ubiquitin ligase that interacts with both MyD88 and TRIF, regulated the production of interferon and proinflammatory cytokines in different ways. Degradative ubiquitination of TRAF3 during MyD88-dependent TLR signaling was essential for the activation of mitogen-activated protein kinases (MAPKs) and production of inflammatory cytokines. In contrast, TRIF-dependent signaling triggered noncanonical TRAF3 self-ubiquitination that activated the interferon response. Inhibition of degradative ubiquitination of TRAF3 prevented the expression of all proinflammatory cytokines without affecting the interferon response.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ni.1819", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2479741", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438833", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2454205", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2665920", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2455904", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2597939", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1022778", 
            "issn": [
              "1529-2908", 
              "1529-2916"
            ], 
            "name": "Nature Immunology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "11"
          }
        ], 
        "name": "Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines", 
        "pagination": "70-75", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "3907d476e1d33ff854bdd3e464c54030572d4be045a614a3d4f702a079a9784a"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19898473"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100941354"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ni.1819"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1011969709"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ni.1819", 
          "https://app.dimensions.ai/details/publication/pub.1011969709"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:32", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99809_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/ni/journal/v11/n1/full/ni.1819.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ni.1819'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni.1819'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ni.1819'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni.1819'


     

    This table displays all metadata directly associated to this object as RDF triples.

    371 TRIPLES      21 PREDICATES      97 URIs      45 LITERALS      33 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ni.1819 schema:about N0fd5621e395949998eefe001e2708cce
    2 N181feabc7ae949539fad35159f4d48ea
    3 N202353e1ee614d0d950ef7b35387b2f5
    4 N3237f0be24114fbc88b584d0650b81b5
    5 N3c91c3bea0cb41acaff974237ddb68e2
    6 N6223aa11c92644d1ae47c9c690f19933
    7 N70720388e3204c4da356d724b157df23
    8 N709193a4af8c4acc8b9cbc3b9e3003aa
    9 N78e5946d84b146e2abcb9bdafb5de9b3
    10 N877add1234ff41a39416aa1632906eb5
    11 N8edfdf381cab47f0a352e3dc65080c55
    12 N9d24b8d71d9a45ed99187165fede5cb4
    13 Nc4efc4b228154356bfd4e0caf7f5d336
    14 Nc6bd65dbc2a643c3a3ca31e5975c435e
    15 Nce8f2f0aa42f40a8b227488560c3a61f
    16 Nd10f03273f914d59b9c23fc4b390360b
    17 Nd59ca899ac3b4b748888a0a4d50037e1
    18 Ndf0738d4c06146dba1b8341890350af0
    19 Ne587e2aaeb374231aa59cbcdaa7a2f06
    20 Ne708fce72b6642b3a591ff3b5d37f7cd
    21 Ne907f0874a3749a982c2d23a9883a7f2
    22 Neb3b5b9282734b949015cfd3f4078064
    23 Ned43751f066846e3986bbb4ba23c7736
    24 Nfcb53fcbeab64a0791751c6f54a970b1
    25 anzsrc-for:11
    26 anzsrc-for:1107
    27 schema:author N469148e9d1e5451c80bc104d1f26ecab
    28 schema:citation sg:pub.10.1007/0-387-24180-9_2
    29 sg:pub.10.1007/978-0-387-70630-6_6
    30 sg:pub.10.1007/978-0-387-70630-6_7
    31 sg:pub.10.1038/35092578
    32 sg:pub.10.1038/416345a
    33 sg:pub.10.1038/nature01889
    34 sg:pub.10.1038/nature03491
    35 sg:pub.10.1038/nature04369
    36 sg:pub.10.1038/nature04374
    37 sg:pub.10.1038/ni.1678
    38 sg:pub.10.1038/ni0901-835
    39 sg:pub.10.1038/ni1255
    40 sg:pub.10.1038/ni1367
    41 sg:pub.10.1038/ni1569
    42 sg:pub.10.1038/ni986
    43 sg:pub.10.1038/nri1391
    44 sg:pub.10.1038/nri2079
    45 sg:pub.10.1038/nrm1621
    46 https://app.dimensions.ai/details/publication/pub.1062438406
    47 https://doi.org/10.1016/0006-291x(77)90249-2
    48 https://doi.org/10.1016/j.ccr.2004.08.012
    49 https://doi.org/10.1016/j.ccr.2007.07.003
    50 https://doi.org/10.1016/j.ccr.2007.08.029
    51 https://doi.org/10.1016/j.cell.2006.02.016
    52 https://doi.org/10.1016/j.devcel.2006.04.002
    53 https://doi.org/10.1016/j.immuni.2005.08.010
    54 https://doi.org/10.1016/j.immuni.2006.08.010
    55 https://doi.org/10.1016/j.smim.2006.12.004
    56 https://doi.org/10.1016/s0092-8674(03)00521-x
    57 https://doi.org/10.1016/s1074-7613(00)80086-2
    58 https://doi.org/10.1016/s1074-7613(02)00390-4
    59 https://doi.org/10.1016/s1097-2765(00)80136-7
    60 https://doi.org/10.1046/j.1365-2443.2001.00426.x
    61 https://doi.org/10.1074/jbc.m104994200
    62 https://doi.org/10.1074/jbc.m303451200
    63 https://doi.org/10.1074/jbc.m609503200
    64 https://doi.org/10.1074/jbc.r700009200
    65 https://doi.org/10.1083/jcb.111.5.1811
    66 https://doi.org/10.1124/mi.3.8.466
    67 https://doi.org/10.1126/science.1098231
    68 https://doi.org/10.1126/science.1157340
    69 https://doi.org/10.1172/jci31537
    70 https://doi.org/10.1371/journal.pone.0000788
    71 https://doi.org/10.4049/jimmunol.169.12.6668
    72 schema:datePublished 2010-01
    73 schema:datePublishedReg 2010-01-01
    74 schema:description Balanced production of type I interferons and proinflammatory cytokines after engagement of Toll-like receptors (TLRs), which signal through adaptors containing a Toll-interleukin 1 receptor (TIR) domain, such as MyD88 and TRIF, has been proposed to control the pathogenesis of autoimmune disease and tumor responses to inflammation. Here we show that TRAF3, a ubiquitin ligase that interacts with both MyD88 and TRIF, regulated the production of interferon and proinflammatory cytokines in different ways. Degradative ubiquitination of TRAF3 during MyD88-dependent TLR signaling was essential for the activation of mitogen-activated protein kinases (MAPKs) and production of inflammatory cytokines. In contrast, TRIF-dependent signaling triggered noncanonical TRAF3 self-ubiquitination that activated the interferon response. Inhibition of degradative ubiquitination of TRAF3 prevented the expression of all proinflammatory cytokines without affecting the interferon response.
    75 schema:genre research_article
    76 schema:inLanguage en
    77 schema:isAccessibleForFree true
    78 schema:isPartOf N3ea435cae20a4262ab51c1146c9e0dbb
    79 Ncacde754287a47a799d366649c054f03
    80 sg:journal.1022778
    81 schema:name Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
    82 schema:pagination 70-75
    83 schema:productId N0e704d45d05044f58e8b4ac5d7dce90e
    84 N3b5b51eb735643dba33f0e5d745c3cfe
    85 N487ecf5ba284445396a21a702068f624
    86 Nb55f0251e1854d5698cf3cfd60827a64
    87 Ncb8f77131cbc454c85dd622fa29797a6
    88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011969709
    89 https://doi.org/10.1038/ni.1819
    90 schema:sdDatePublished 2019-04-11T09:32
    91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    92 schema:sdPublisher Nea66780747454cb4bacd15d974439697
    93 schema:url http://www.nature.com/ni/journal/v11/n1/full/ni.1819.html
    94 sgo:license sg:explorer/license/
    95 sgo:sdDataset articles
    96 rdf:type schema:ScholarlyArticle
    97 N06a9e45383b04775a0d396ce6d8110c7 rdf:first sg:person.0711622372.47
    98 rdf:rest Nfe03bfcc9c9544a38ce0dbcda70f9970
    99 N06f4d5e54b434727b08ba713e4801697 rdf:first sg:person.01012667130.18
    100 rdf:rest Ncb589926b32948e089dfb6281f44efb5
    101 N0c7458d87f024eb2959dd236473c87ce schema:affiliation https://www.grid.ac/institutes/grid.266100.3
    102 schema:familyName Mino
    103 schema:givenName Takashi
    104 rdf:type schema:Person
    105 N0e704d45d05044f58e8b4ac5d7dce90e schema:name readcube_id
    106 schema:value 3907d476e1d33ff854bdd3e464c54030572d4be045a614a3d4f702a079a9784a
    107 rdf:type schema:PropertyValue
    108 N0fd5621e395949998eefe001e2708cce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Lipopolysaccharides
    110 rdf:type schema:DefinedTerm
    111 N181feabc7ae949539fad35159f4d48ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Adaptor Proteins, Vesicular Transport
    113 rdf:type schema:DefinedTerm
    114 N202353e1ee614d0d950ef7b35387b2f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Inhibitor of Apoptosis Proteins
    116 rdf:type schema:DefinedTerm
    117 N3237f0be24114fbc88b584d0650b81b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Cytokines
    119 rdf:type schema:DefinedTerm
    120 N3b5b51eb735643dba33f0e5d745c3cfe schema:name nlm_unique_id
    121 schema:value 100941354
    122 rdf:type schema:PropertyValue
    123 N3c91c3bea0cb41acaff974237ddb68e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Mice, Inbred C57BL
    125 rdf:type schema:DefinedTerm
    126 N3ea435cae20a4262ab51c1146c9e0dbb schema:volumeNumber 11
    127 rdf:type schema:PublicationVolume
    128 N469148e9d1e5451c80bc104d1f26ecab rdf:first sg:person.01057655622.51
    129 rdf:rest N06f4d5e54b434727b08ba713e4801697
    130 N487ecf5ba284445396a21a702068f624 schema:name dimensions_id
    131 schema:value pub.1011969709
    132 rdf:type schema:PropertyValue
    133 N6223aa11c92644d1ae47c9c690f19933 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name TNF Receptor-Associated Factor 3
    135 rdf:type schema:DefinedTerm
    136 N70720388e3204c4da356d724b157df23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name TNF Receptor-Associated Factor 6
    138 rdf:type schema:DefinedTerm
    139 N709193a4af8c4acc8b9cbc3b9e3003aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Mitogen-Activated Protein Kinases
    141 rdf:type schema:DefinedTerm
    142 N78e5946d84b146e2abcb9bdafb5de9b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Gene Expression Regulation
    144 rdf:type schema:DefinedTerm
    145 N877add1234ff41a39416aa1632906eb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Immunoblotting
    147 rdf:type schema:DefinedTerm
    148 N8edfdf381cab47f0a352e3dc65080c55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Inflammation Mediators
    150 rdf:type schema:DefinedTerm
    151 N9d24b8d71d9a45ed99187165fede5cb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Macrophages
    153 rdf:type schema:DefinedTerm
    154 Nb55f0251e1854d5698cf3cfd60827a64 schema:name pubmed_id
    155 schema:value 19898473
    156 rdf:type schema:PropertyValue
    157 Nc4efc4b228154356bfd4e0caf7f5d336 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Toll-Like Receptor 4
    159 rdf:type schema:DefinedTerm
    160 Nc6bd65dbc2a643c3a3ca31e5975c435e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Signal Transduction
    162 rdf:type schema:DefinedTerm
    163 Ncacde754287a47a799d366649c054f03 schema:issueNumber 1
    164 rdf:type schema:PublicationIssue
    165 Ncb589926b32948e089dfb6281f44efb5 rdf:first sg:person.01311621713.63
    166 rdf:rest Nce00688c072e4ab8aa91579adce12466
    167 Ncb8f77131cbc454c85dd622fa29797a6 schema:name doi
    168 schema:value 10.1038/ni.1819
    169 rdf:type schema:PropertyValue
    170 Nce00688c072e4ab8aa91579adce12466 rdf:first N0c7458d87f024eb2959dd236473c87ce
    171 rdf:rest N06a9e45383b04775a0d396ce6d8110c7
    172 Nce8f2f0aa42f40a8b227488560c3a61f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Cell Line
    174 rdf:type schema:DefinedTerm
    175 Nd10f03273f914d59b9c23fc4b390360b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Interferon Type I
    177 rdf:type schema:DefinedTerm
    178 Nd59ca899ac3b4b748888a0a4d50037e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Protein Binding
    180 rdf:type schema:DefinedTerm
    181 Ndf0738d4c06146dba1b8341890350af0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Mice
    183 rdf:type schema:DefinedTerm
    184 Ne587e2aaeb374231aa59cbcdaa7a2f06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Reverse Transcriptase Polymerase Chain Reaction
    186 rdf:type schema:DefinedTerm
    187 Ne708fce72b6642b3a591ff3b5d37f7cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Animals
    189 rdf:type schema:DefinedTerm
    190 Ne907f0874a3749a982c2d23a9883a7f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Phosphorylation
    192 rdf:type schema:DefinedTerm
    193 Nea66780747454cb4bacd15d974439697 schema:name Springer Nature - SN SciGraph project
    194 rdf:type schema:Organization
    195 Neb3b5b9282734b949015cfd3f4078064 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Myeloid Differentiation Factor 88
    197 rdf:type schema:DefinedTerm
    198 Ned43751f066846e3986bbb4ba23c7736 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Ubiquitination
    200 rdf:type schema:DefinedTerm
    201 Nfcb53fcbeab64a0791751c6f54a970b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Mice, Knockout
    203 rdf:type schema:DefinedTerm
    204 Nfe03bfcc9c9544a38ce0dbcda70f9970 rdf:first sg:person.0706540600.87
    205 rdf:rest rdf:nil
    206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    207 schema:name Medical and Health Sciences
    208 rdf:type schema:DefinedTerm
    209 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Immunology
    211 rdf:type schema:DefinedTerm
    212 sg:grant.2438833 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1819
    213 rdf:type schema:MonetaryGrant
    214 sg:grant.2454205 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1819
    215 rdf:type schema:MonetaryGrant
    216 sg:grant.2455904 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1819
    217 rdf:type schema:MonetaryGrant
    218 sg:grant.2479741 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1819
    219 rdf:type schema:MonetaryGrant
    220 sg:grant.2597939 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1819
    221 rdf:type schema:MonetaryGrant
    222 sg:grant.2665920 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1819
    223 rdf:type schema:MonetaryGrant
    224 sg:journal.1022778 schema:issn 1529-2908
    225 1529-2916
    226 schema:name Nature Immunology
    227 rdf:type schema:Periodical
    228 sg:person.01012667130.18 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    229 schema:familyName Matsuzawa
    230 schema:givenName Atsushi
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012667130.18
    232 rdf:type schema:Person
    233 sg:person.01057655622.51 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
    234 schema:familyName Tseng
    235 schema:givenName Ping-Hui
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057655622.51
    237 rdf:type schema:Person
    238 sg:person.01311621713.63 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
    239 schema:familyName Zhang
    240 schema:givenName Weizhou
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311621713.63
    242 rdf:type schema:Person
    243 sg:person.0706540600.87 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
    244 schema:familyName Karin
    245 schema:givenName Michael
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706540600.87
    247 rdf:type schema:Person
    248 sg:person.0711622372.47 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
    249 schema:familyName Vignali
    250 schema:givenName Dario A A
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711622372.47
    252 rdf:type schema:Person
    253 sg:pub.10.1007/0-387-24180-9_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017918564
    254 https://doi.org/10.1007/0-387-24180-9_2
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1007/978-0-387-70630-6_6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025684039
    257 https://doi.org/10.1007/978-0-387-70630-6_6
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1007/978-0-387-70630-6_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020499530
    260 https://doi.org/10.1007/978-0-387-70630-6_7
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/35092578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012150444
    263 https://doi.org/10.1038/35092578
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/416345a schema:sameAs https://app.dimensions.ai/details/publication/pub.1047676603
    266 https://doi.org/10.1038/416345a
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/nature01889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050980808
    269 https://doi.org/10.1038/nature01889
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nature03491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031720585
    272 https://doi.org/10.1038/nature03491
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nature04369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011667818
    275 https://doi.org/10.1038/nature04369
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/nature04374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015350802
    278 https://doi.org/10.1038/nature04374
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/ni.1678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017708694
    281 https://doi.org/10.1038/ni.1678
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/ni0901-835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037156244
    284 https://doi.org/10.1038/ni0901-835
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/ni1255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016882586
    287 https://doi.org/10.1038/ni1255
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/ni1367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009798136
    290 https://doi.org/10.1038/ni1367
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/ni1569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032207157
    293 https://doi.org/10.1038/ni1569
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/ni986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030777085
    296 https://doi.org/10.1038/ni986
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/nri1391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023753307
    299 https://doi.org/10.1038/nri1391
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/nri2079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005511542
    302 https://doi.org/10.1038/nri2079
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/nrm1621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032010638
    305 https://doi.org/10.1038/nrm1621
    306 rdf:type schema:CreativeWork
    307 https://app.dimensions.ai/details/publication/pub.1062438406 schema:CreativeWork
    308 https://doi.org/10.1016/0006-291x(77)90249-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019181050
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/j.ccr.2004.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046593922
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/j.ccr.2007.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025985820
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/j.ccr.2007.08.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008093277
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/j.cell.2006.02.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037898031
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/j.devcel.2006.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035479622
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/j.immuni.2005.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006857288
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/j.immuni.2006.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044397575
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/j.smim.2006.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041216221
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1016/s0092-8674(03)00521-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029513979
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1016/s1074-7613(00)80086-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044146057
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1016/s1074-7613(02)00390-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043398905
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1016/s1097-2765(00)80136-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044317166
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1046/j.1365-2443.2001.00426.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025945490
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1074/jbc.m104994200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029462603
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1074/jbc.m303451200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035774951
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1074/jbc.m609503200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037225474
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1074/jbc.r700009200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044883374
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1083/jcb.111.5.1811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052111633
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1124/mi.3.8.466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062438406
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1126/science.1098231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062449652
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1126/science.1157340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011843378
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1172/jci31537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027236338
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1371/journal.pone.0000788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007384798
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.4049/jimmunol.169.12.6668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027946692
    357 rdf:type schema:CreativeWork
    358 https://www.grid.ac/institutes/grid.240871.8 schema:alternateName St. Jude Children's Research Hospital
    359 schema:name Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
    360 rdf:type schema:Organization
    361 https://www.grid.ac/institutes/grid.260770.4 schema:alternateName National Yang Ming University
    362 schema:name Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan.
    363 Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, USA.
    364 rdf:type schema:Organization
    365 https://www.grid.ac/institutes/grid.266100.3 schema:alternateName University of California, San Diego
    366 schema:name Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, USA.
    367 rdf:type schema:Organization
    368 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
    369 schema:name Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
    370 Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, USA.
    371 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...