Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-08

AUTHORS

Andy L Johnson, L Aravind, Natalia Shulzhenko, Andre Morgun, See-Young Choi, Tanya L Crockford, Teresa Lambe, Heather Domaschenz, Edyta M Kucharska, Lixin Zheng, Carola G Vinuesa, Michael J Lenardo, Christopher C Goodnow, Richard J Cornall, Ronald H Schwartz

ABSTRACT

T cell antigen receptor (TCR) signaling in CD4(+)CD8(+) double-positive thymocytes determines cell survival and lineage commitment, but the genetic and molecular basis of this process is poorly defined. To address this issue, we used ethylnitrosourea mutagenesis to identify a previously unknown T lineage-specific gene, Themis, which is critical for the completion of positive selection. Themis contains a tandem repeat of a unique globular domain (called 'CABIT' here) that includes a cysteine motif that defines a family of five uncharacterized vertebrate proteins with orthologs in most animal species. Themis-deficient thymocytes showed no substantial impairment in early TCR signaling but did show altered expression of genes involved in the cell cycle and survival before and during positive selection. Our data suggest a unique function for Themis in sustaining positive selection. More... »

PAGES

831-839

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni.1769

DOI

http://dx.doi.org/10.1038/ni.1769

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009622882

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19597497


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