The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-03

AUTHORS

Mandy J McGeachy, Yi Chen, Cristina M Tato, Arian Laurence, Barbara Joyce-Shaikh, Wendy M Blumenschein, Terrill K McClanahan, John J O'Shea, Daniel J Cua

ABSTRACT

Interleukin 23 (IL-23) is required for autoimmune inflammation mediated by IL-17-producing helper T cells (T(H)-17 cells) and has been linked to many human immune disorders. Here we restricted deficiency in the IL-23 receptor to defined cell populations in vivo to investigate the requirement for IL-23 signaling in the development and function of T(H)-17 cells in autoimmunity, inflammation and infection. In the absence of IL-23, T(H)-17 development was stalled at the early activation stage. T(H)-17 cells failed to downregulate IL-2 and also failed to maintain IL-17 production or upregulate expression of the IL-7 receptor alpha-chain. These defects were associated with less proliferation; consequently, fewer effector T(H)-17 cells were produced in the lymph nodes and hence available to emigrate to the bloodstream and tissues. More... »

PAGES

314-324

References to SciGraph publications

  • 2004-01. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 in NATURE
  • 2003-02. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain in NATURE
  • 2006-05. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells in NATURE
  • 2006-05. Transforming growth factor-β induces development of the TH17 lineage in NATURE
  • 2007-04. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge in NATURE IMMUNOLOGY
  • 2007-12. TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology in NATURE IMMUNOLOGY
  • 2007-02. Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis in NATURE
  • 2007-06. Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells in NATURE IMMUNOLOGY
  • 2007-09. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways in NATURE IMMUNOLOGY
  • 2005-11. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 in NATURE IMMUNOLOGY
  • 2005-11. Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages in NATURE IMMUNOLOGY
  • 2008-05. Polymorphisms in the IL-12β and IL-23R Genes Are Associated with Psoriasis of Early Onset in a UK Cohort in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2007-07. IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells in NATURE
  • 2007-07. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells in NATURE
  • 2006-11. Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease in NATURE IMMUNOLOGY
  • 2007-09. Development, cytokine profile and function of human interleukin 17–producing helper T cells in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.1698

    DOI

    http://dx.doi.org/10.1038/ni.1698

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031138082

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19182808


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Encephalomyelitis, Autoimmune, Experimental", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-17", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphocyte Activation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Interleukin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "STAT3 Transcription Factor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocytes, Helper-Inducer", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Toxoplasmosis, Animal", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Schering-Plough Biopharma, Palo Alto, California 94304, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "McGeachy", 
            "givenName": "Mandy J", 
            "id": "sg:person.01003516413.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003516413.49"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Chen", 
            "givenName": "Yi", 
            "id": "sg:person.01020333244.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020333244.46"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Tato", 
            "givenName": "Cristina M", 
            "id": "sg:person.01004421755.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004421755.97"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Laurence", 
            "givenName": "Arian", 
            "id": "sg:person.0744137763.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744137763.95"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Joyce-Shaikh", 
            "givenName": "Barbara", 
            "id": "sg:person.01102467200.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102467200.00"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Blumenschein", 
            "givenName": "Wendy M", 
            "id": "sg:person.01307504503.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307504503.01"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "McClanahan", 
            "givenName": "Terrill K", 
            "id": "sg:person.01236405645.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236405645.10"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "O'Shea", 
            "givenName": "John J", 
            "id": "sg:person.0611511210.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611511210.03"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Cua", 
            "givenName": "Daniel J", 
            "id": "sg:person.01313460060.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313460060.40"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature01355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001374380", 
              "https://doi.org/10.1038/nature01355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001933444", 
              "https://doi.org/10.1038/ni1539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002269423", 
              "https://doi.org/10.1038/ni1488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2007.02.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002629248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2007.04.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004557776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.179.7.4313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005555088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.178.8.4901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007827201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007842569", 
              "https://doi.org/10.1038/nature05505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007842569", 
              "https://doi.org/10.1038/nature05505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(02)00391-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009123811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2006.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009201806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80605-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009513720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/iai.00621-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010287811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20041257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013395893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa062382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015387041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.c600321200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016034873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20061198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016096057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20030735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016098368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2007.03.104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016447266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019330185", 
              "https://doi.org/10.1038/ni1449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)00070-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023691475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.1995.tb00071.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024931585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2007.11.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030088683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030750872", 
              "https://doi.org/10.1038/ni1261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030750872", 
              "https://doi.org/10.1038/ni1261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.02.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030868651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.it.2005.10.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032591308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.it.2005.10.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032591308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20061308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033164618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20061099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034826951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20030896", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035188143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20062381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035270352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20070663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035281564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05970", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035445598", 
              "https://doi.org/10.1038/nature05970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037247321", 
              "https://doi.org/10.1038/nature04753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037247321", 
              "https://doi.org/10.1038/nature04753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037682433", 
              "https://doi.org/10.1038/nature05969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.168.11.5699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037908336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038187346", 
              "https://doi.org/10.1038/ni1467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1135245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040685270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20060244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043237722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043435108", 
              "https://doi.org/10.1038/ni1497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.175.10.6489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044820585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jid.5701140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046661524", 
              "https://doi.org/10.1038/sj.jid.5701140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.07.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046724496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048891965", 
              "https://doi.org/10.1038/nature02284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048891965", 
              "https://doi.org/10.1038/nature02284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20030725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050712192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051485127", 
              "https://doi.org/10.1038/ni1254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051485127", 
              "https://doi.org/10.1038/ni1254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051631879", 
              "https://doi.org/10.1038/ni1391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051631879", 
              "https://doi.org/10.1038/ni1391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.173.3.1887", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076868453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.177.11.7980", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077326010"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-03", 
        "datePublishedReg": "2009-03-01", 
        "description": "Interleukin 23 (IL-23) is required for autoimmune inflammation mediated by IL-17-producing helper T cells (T(H)-17 cells) and has been linked to many human immune disorders. Here we restricted deficiency in the IL-23 receptor to defined cell populations in vivo to investigate the requirement for IL-23 signaling in the development and function of T(H)-17 cells in autoimmunity, inflammation and infection. In the absence of IL-23, T(H)-17 development was stalled at the early activation stage. T(H)-17 cells failed to downregulate IL-2 and also failed to maintain IL-17 production or upregulate expression of the IL-7 receptor alpha-chain. These defects were associated with less proliferation; consequently, fewer effector T(H)-17 cells were produced in the lymph nodes and hence available to emigrate to the bloodstream and tissues.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ni.1698", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2723475", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1022778", 
            "issn": [
              "1529-2908", 
              "1529-2916"
            ], 
            "name": "Nature Immunology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17\u2013producing effector T helper cells in vivo", 
        "pagination": "314-324", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "9456a40b486ba0ab0859112846499cbbf708bbb657b1f60a08618da79f6564de"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19182808"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100941354"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ni.1698"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1031138082"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ni.1698", 
          "https://app.dimensions.ai/details/publication/pub.1031138082"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:04", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000425.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/ni/journal/v10/n3/full/ni.1698.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ni.1698'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni.1698'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ni.1698'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni.1698'


     

    This table displays all metadata directly associated to this object as RDF triples.

    338 TRIPLES      21 PREDICATES      92 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ni.1698 schema:about N064d87bd6d494636b6505b02c3e14a47
    2 N1cef574beaba4c1db96aba95bbc97af1
    3 N25ee8a08fe3145f284fa8668766997a7
    4 N3d8d88eb9e3c4d8dbf3ce02662b1437b
    5 N66bfddc0c6e24c1b9e559cfee151106e
    6 N68843593e772418d922d3ad1c5adeff2
    7 N7feeb9e9b2de4af588bbdc44252ce5e4
    8 N8a678fc4b82c4a7fa3727563045dad90
    9 N937d93b9b0134e248b24a549f95928b8
    10 Na098833cfe5a47fb9658dfe1ec1f0448
    11 Nb7c1f799eb604de7bd6078d8f27759bb
    12 Nbc04b40def604918a1896650492e2fc0
    13 Nbd81b6d1b9434d5380f9bf6c93f8707b
    14 Ndaf5e21ca1bb4b018ea36e3e0cc4cda1
    15 Ndb0a98a1ff8c4cfab85f00d7a837de75
    16 anzsrc-for:11
    17 anzsrc-for:1107
    18 schema:author Nb1e3a9017a2a49e791aad42782dea233
    19 schema:citation sg:pub.10.1038/nature01355
    20 sg:pub.10.1038/nature02284
    21 sg:pub.10.1038/nature04753
    22 sg:pub.10.1038/nature04754
    23 sg:pub.10.1038/nature05505
    24 sg:pub.10.1038/nature05969
    25 sg:pub.10.1038/nature05970
    26 sg:pub.10.1038/ni1254
    27 sg:pub.10.1038/ni1261
    28 sg:pub.10.1038/ni1391
    29 sg:pub.10.1038/ni1449
    30 sg:pub.10.1038/ni1467
    31 sg:pub.10.1038/ni1488
    32 sg:pub.10.1038/ni1497
    33 sg:pub.10.1038/ni1539
    34 sg:pub.10.1038/sj.jid.5701140
    35 https://doi.org/10.1016/j.cell.2006.07.035
    36 https://doi.org/10.1016/j.coi.2007.04.015
    37 https://doi.org/10.1016/j.immuni.2006.01.001
    38 https://doi.org/10.1016/j.immuni.2007.02.009
    39 https://doi.org/10.1016/j.immuni.2007.11.016
    40 https://doi.org/10.1016/j.immuni.2008.02.019
    41 https://doi.org/10.1016/j.it.2005.10.003
    42 https://doi.org/10.1016/s1074-7613(00)00070-4
    43 https://doi.org/10.1016/s1074-7613(00)80605-6
    44 https://doi.org/10.1016/s1074-7613(02)00391-6
    45 https://doi.org/10.1053/j.gastro.2007.03.104
    46 https://doi.org/10.1056/nejmoa062382
    47 https://doi.org/10.1074/jbc.c600321200
    48 https://doi.org/10.1084/jem.20030725
    49 https://doi.org/10.1084/jem.20030735
    50 https://doi.org/10.1084/jem.20030896
    51 https://doi.org/10.1084/jem.20041257
    52 https://doi.org/10.1084/jem.20060244
    53 https://doi.org/10.1084/jem.20061099
    54 https://doi.org/10.1084/jem.20061198
    55 https://doi.org/10.1084/jem.20061308
    56 https://doi.org/10.1084/jem.20062381
    57 https://doi.org/10.1084/jem.20070663
    58 https://doi.org/10.1111/j.1600-065x.1995.tb00071.x
    59 https://doi.org/10.1126/science.1135245
    60 https://doi.org/10.1128/iai.00621-06
    61 https://doi.org/10.4049/jimmunol.168.11.5699
    62 https://doi.org/10.4049/jimmunol.173.3.1887
    63 https://doi.org/10.4049/jimmunol.175.10.6489
    64 https://doi.org/10.4049/jimmunol.177.11.7980
    65 https://doi.org/10.4049/jimmunol.178.8.4901
    66 https://doi.org/10.4049/jimmunol.179.7.4313
    67 schema:datePublished 2009-03
    68 schema:datePublishedReg 2009-03-01
    69 schema:description Interleukin 23 (IL-23) is required for autoimmune inflammation mediated by IL-17-producing helper T cells (T(H)-17 cells) and has been linked to many human immune disorders. Here we restricted deficiency in the IL-23 receptor to defined cell populations in vivo to investigate the requirement for IL-23 signaling in the development and function of T(H)-17 cells in autoimmunity, inflammation and infection. In the absence of IL-23, T(H)-17 development was stalled at the early activation stage. T(H)-17 cells failed to downregulate IL-2 and also failed to maintain IL-17 production or upregulate expression of the IL-7 receptor alpha-chain. These defects were associated with less proliferation; consequently, fewer effector T(H)-17 cells were produced in the lymph nodes and hence available to emigrate to the bloodstream and tissues.
    70 schema:genre research_article
    71 schema:inLanguage en
    72 schema:isAccessibleForFree true
    73 schema:isPartOf N93b5cea31f00400089ab2124e704a266
    74 Nc5c806d337384ebdb436716ef94d18f0
    75 sg:journal.1022778
    76 schema:name The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo
    77 schema:pagination 314-324
    78 schema:productId N0c4edd4702fc4bad94c38eff0fb19b8f
    79 N105d461d17d645e28f98f9f63551c6b8
    80 N3c34a464ce144e5485544dcbb693d18e
    81 Nbb5eb7c516d14450a0cff6d2fb5a195c
    82 Nfbbecf756a9c4e438ee40ec41ad550d8
    83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031138082
    84 https://doi.org/10.1038/ni.1698
    85 schema:sdDatePublished 2019-04-11T00:04
    86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    87 schema:sdPublisher Nf2535f5357274215b0d4eee1d506a07d
    88 schema:url http://www.nature.com/ni/journal/v10/n3/full/ni.1698.html
    89 sgo:license sg:explorer/license/
    90 sgo:sdDataset articles
    91 rdf:type schema:ScholarlyArticle
    92 N04332f83ac0c406c8e35a8cddc06fe0b rdf:first sg:person.01102467200.00
    93 rdf:rest Ndad2fc6930064d9ba5d07edbcbccbf6e
    94 N064d87bd6d494636b6505b02c3e14a47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name T-Lymphocytes, Helper-Inducer
    96 rdf:type schema:DefinedTerm
    97 N0c4edd4702fc4bad94c38eff0fb19b8f schema:name nlm_unique_id
    98 schema:value 100941354
    99 rdf:type schema:PropertyValue
    100 N105d461d17d645e28f98f9f63551c6b8 schema:name readcube_id
    101 schema:value 9456a40b486ba0ab0859112846499cbbf708bbb657b1f60a08618da79f6564de
    102 rdf:type schema:PropertyValue
    103 N1cef574beaba4c1db96aba95bbc97af1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Female
    105 rdf:type schema:DefinedTerm
    106 N25ee8a08fe3145f284fa8668766997a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Mice, Inbred C57BL
    108 rdf:type schema:DefinedTerm
    109 N32e8fb04933a4eb582ef862a3ed167b4 rdf:first sg:person.0744137763.95
    110 rdf:rest N04332f83ac0c406c8e35a8cddc06fe0b
    111 N3c34a464ce144e5485544dcbb693d18e schema:name doi
    112 schema:value 10.1038/ni.1698
    113 rdf:type schema:PropertyValue
    114 N3d8d88eb9e3c4d8dbf3ce02662b1437b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Lymphocyte Activation
    116 rdf:type schema:DefinedTerm
    117 N66bfddc0c6e24c1b9e559cfee151106e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Toxoplasmosis, Animal
    119 rdf:type schema:DefinedTerm
    120 N68843593e772418d922d3ad1c5adeff2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Receptors, Interleukin
    122 rdf:type schema:DefinedTerm
    123 N69a3c2bd804f47c49fcc0b1ad12607f5 schema:name Schering-Plough Biopharma, Palo Alto, California 94304, USA.
    124 rdf:type schema:Organization
    125 N7feeb9e9b2de4af588bbdc44252ce5e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Animals
    127 rdf:type schema:DefinedTerm
    128 N8a678fc4b82c4a7fa3727563045dad90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Encephalomyelitis, Autoimmune, Experimental
    130 rdf:type schema:DefinedTerm
    131 N937d93b9b0134e248b24a549f95928b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name STAT3 Transcription Factor
    133 rdf:type schema:DefinedTerm
    134 N93b5cea31f00400089ab2124e704a266 schema:issueNumber 3
    135 rdf:type schema:PublicationIssue
    136 Na098833cfe5a47fb9658dfe1ec1f0448 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Mice
    138 rdf:type schema:DefinedTerm
    139 Nab06a6e8661e4b508a8a703140956c06 rdf:first sg:person.01313460060.40
    140 rdf:rest rdf:nil
    141 Nb1e3a9017a2a49e791aad42782dea233 rdf:first sg:person.01003516413.49
    142 rdf:rest Nf9340175de984369a93ced742fe9bb6a
    143 Nb7c1f799eb604de7bd6078d8f27759bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Interleukin-2
    145 rdf:type schema:DefinedTerm
    146 Nbb5eb7c516d14450a0cff6d2fb5a195c schema:name dimensions_id
    147 schema:value pub.1031138082
    148 rdf:type schema:PropertyValue
    149 Nbc04b40def604918a1896650492e2fc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Mice, Knockout
    151 rdf:type schema:DefinedTerm
    152 Nbd81b6d1b9434d5380f9bf6c93f8707b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Interleukin-17
    154 rdf:type schema:DefinedTerm
    155 Nbe4a1eeb20b5481fb0ac82f8558f2352 rdf:first sg:person.01004421755.97
    156 rdf:rest N32e8fb04933a4eb582ef862a3ed167b4
    157 Nc5c806d337384ebdb436716ef94d18f0 schema:volumeNumber 10
    158 rdf:type schema:PublicationVolume
    159 Ndad2fc6930064d9ba5d07edbcbccbf6e rdf:first sg:person.01307504503.01
    160 rdf:rest Ne84ee13621154059a4d2fd1bfad44d7f
    161 Ndaf5e21ca1bb4b018ea36e3e0cc4cda1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Cell Proliferation
    163 rdf:type schema:DefinedTerm
    164 Ndb0a98a1ff8c4cfab85f00d7a837de75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Cell Differentiation
    166 rdf:type schema:DefinedTerm
    167 Ne1526f3c0444470db8c8223009525ef4 rdf:first sg:person.0611511210.03
    168 rdf:rest Nab06a6e8661e4b508a8a703140956c06
    169 Ne84ee13621154059a4d2fd1bfad44d7f rdf:first sg:person.01236405645.10
    170 rdf:rest Ne1526f3c0444470db8c8223009525ef4
    171 Nf2535f5357274215b0d4eee1d506a07d schema:name Springer Nature - SN SciGraph project
    172 rdf:type schema:Organization
    173 Nf9340175de984369a93ced742fe9bb6a rdf:first sg:person.01020333244.46
    174 rdf:rest Nbe4a1eeb20b5481fb0ac82f8558f2352
    175 Nfbbecf756a9c4e438ee40ec41ad550d8 schema:name pubmed_id
    176 schema:value 19182808
    177 rdf:type schema:PropertyValue
    178 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Medical and Health Sciences
    180 rdf:type schema:DefinedTerm
    181 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    182 schema:name Immunology
    183 rdf:type schema:DefinedTerm
    184 sg:grant.2723475 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1698
    185 rdf:type schema:MonetaryGrant
    186 sg:journal.1022778 schema:issn 1529-2908
    187 1529-2916
    188 schema:name Nature Immunology
    189 rdf:type schema:Periodical
    190 sg:person.01003516413.49 schema:affiliation N69a3c2bd804f47c49fcc0b1ad12607f5
    191 schema:familyName McGeachy
    192 schema:givenName Mandy J
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003516413.49
    194 rdf:type schema:Person
    195 sg:person.01004421755.97 schema:familyName Tato
    196 schema:givenName Cristina M
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004421755.97
    198 rdf:type schema:Person
    199 sg:person.01020333244.46 schema:familyName Chen
    200 schema:givenName Yi
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020333244.46
    202 rdf:type schema:Person
    203 sg:person.01102467200.00 schema:familyName Joyce-Shaikh
    204 schema:givenName Barbara
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102467200.00
    206 rdf:type schema:Person
    207 sg:person.01236405645.10 schema:familyName McClanahan
    208 schema:givenName Terrill K
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236405645.10
    210 rdf:type schema:Person
    211 sg:person.01307504503.01 schema:familyName Blumenschein
    212 schema:givenName Wendy M
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307504503.01
    214 rdf:type schema:Person
    215 sg:person.01313460060.40 schema:familyName Cua
    216 schema:givenName Daniel J
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313460060.40
    218 rdf:type schema:Person
    219 sg:person.0611511210.03 schema:familyName O'Shea
    220 schema:givenName John J
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611511210.03
    222 rdf:type schema:Person
    223 sg:person.0744137763.95 schema:familyName Laurence
    224 schema:givenName Arian
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744137763.95
    226 rdf:type schema:Person
    227 sg:pub.10.1038/nature01355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001374380
    228 https://doi.org/10.1038/nature01355
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/nature02284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048891965
    231 https://doi.org/10.1038/nature02284
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nature04753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037247321
    234 https://doi.org/10.1038/nature04753
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nature04754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043278106
    237 https://doi.org/10.1038/nature04754
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nature05505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007842569
    240 https://doi.org/10.1038/nature05505
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nature05969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037682433
    243 https://doi.org/10.1038/nature05969
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nature05970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035445598
    246 https://doi.org/10.1038/nature05970
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/ni1254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051485127
    249 https://doi.org/10.1038/ni1254
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/ni1261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030750872
    252 https://doi.org/10.1038/ni1261
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/ni1391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051631879
    255 https://doi.org/10.1038/ni1391
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/ni1449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019330185
    258 https://doi.org/10.1038/ni1449
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/ni1467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038187346
    261 https://doi.org/10.1038/ni1467
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/ni1488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002269423
    264 https://doi.org/10.1038/ni1488
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/ni1497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043435108
    267 https://doi.org/10.1038/ni1497
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/ni1539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001933444
    270 https://doi.org/10.1038/ni1539
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/sj.jid.5701140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046661524
    273 https://doi.org/10.1038/sj.jid.5701140
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.cell.2006.07.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046724496
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.coi.2007.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004557776
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.immuni.2006.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009201806
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.immuni.2007.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002629248
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.immuni.2007.11.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030088683
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.immuni.2008.02.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030868651
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.it.2005.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032591308
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/s1074-7613(00)00070-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023691475
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/s1074-7613(00)80605-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009513720
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/s1074-7613(02)00391-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009123811
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1053/j.gastro.2007.03.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016447266
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1056/nejmoa062382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015387041
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1074/jbc.c600321200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016034873
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1084/jem.20030725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050712192
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1084/jem.20030735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016098368
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1084/jem.20030896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035188143
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1084/jem.20041257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013395893
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1084/jem.20060244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043237722
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1084/jem.20061099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034826951
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1084/jem.20061198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016096057
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1084/jem.20061308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033164618
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1084/jem.20062381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035270352
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1084/jem.20070663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035281564
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1111/j.1600-065x.1995.tb00071.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024931585
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1126/science.1135245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040685270
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1128/iai.00621-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010287811
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.4049/jimmunol.168.11.5699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037908336
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.4049/jimmunol.173.3.1887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076868453
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.4049/jimmunol.175.10.6489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044820585
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.4049/jimmunol.177.11.7980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077326010
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.4049/jimmunol.178.8.4901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007827201
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.4049/jimmunol.179.7.4313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005555088
    338 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...