The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02

AUTHORS

Aurelie T Bauquet, Hulin Jin, Alison M Paterson, Meike Mitsdoerffer, I-Cheng Ho, Arlene H Sharpe, Vijay K Kuchroo

ABSTRACT

The inducible costimulatory molecule ICOS has been suggested to be important in the development of interleukin 17 (IL-17)-producing helper T cells (T(H)-17 cells) and of follicular helper T cells (T(FH) cells). Here we show that ICOS-deficient mice had no defect in T(H)-17 differentiation but had fewer T(H)-17 cells after IL-23 stimulation and fewer T(FH) cells. We also show that T(FH) cells produced IL-17 and that T(FH) cells in ICOS-deficient mice were defective in IL-17 production. Both T(H)-17 and T(FH) cells had higher expression of the transcription factor c-Maf. Genetic loss of c-Maf resulted in a defect in IL-21 production and fewer T(H)-17 and T(FH) cells. Thus our data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of T(H)-17 and T(FH) cells. More... »

PAGES

167-175

References to SciGraph publications

  • 2003-02. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain in NATURE
  • 2006-05. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells in NATURE
  • 2006-05. Transforming growth factor-β induces development of the TH17 lineage in NATURE
  • 2003-08. Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell–dependent B cell responses in NATURE IMMUNOLOGY
  • 2005-05. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity in NATURE
  • 2002-05. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis in NATURE MEDICINE
  • 2001-01. ICOS is critical for CD40-mediated antibody class switching in NATURE
  • 2001-01. ICOS co-stimulatory receptor is essential for T-cell activation and function in NATURE
  • 1997-10. A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis in NATURE
  • 2007-06. TH1 cells control themselves by producing interleukin-10 in NATURE REVIEWS IMMUNOLOGY
  • 2007-11. Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA in NATURE
  • 2007-09. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways in NATURE IMMUNOLOGY
  • 2005-11. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 in NATURE IMMUNOLOGY
  • 2007-07. IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells in NATURE
  • 2001-07. ICOS costimulation: it's not just for TH2 cells anymore in NATURE IMMUNOLOGY
  • 2008-02. Interleukin 17–producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice in NATURE IMMUNOLOGY
  • 1998-10. Interleukin-17 and Interferon-γ Synergize in the Enhancement of Proinflammatory Cytokine Production by Human Keratinocytes in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1999-01. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28 in NATURE
  • 2001-07. Importance of ICOS–B7RP-1 costimulation in acute and chronic allograft rejection in NATURE IMMUNOLOGY
  • 2003-03. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.1690

    DOI

    http://dx.doi.org/10.1038/ni.1690

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044487288

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19098919


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antigens, Differentiation, T-Lymphocyte", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Encephalomyelitis, Autoimmune, Experimental", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enzyme-Linked Immunosorbent Assay", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Flow Cytometry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inducible T-Cell Co-Stimulator Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-17", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Transgenic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oligonucleotide Array Sequence Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins c-maf", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reverse Transcriptase Polymerase Chain Reaction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocyte Subsets", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocytes, Helper-Inducer", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bauquet", 
            "givenName": "Aurelie T", 
            "id": "sg:person.01200406751.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200406751.16"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Jin", 
            "givenName": "Hulin", 
            "id": "sg:person.011171115467.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011171115467.83"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Paterson", 
            "givenName": "Alison M", 
            "id": "sg:person.0715160101.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715160101.73"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Mitsdoerffer", 
            "givenName": "Meike", 
            "id": "sg:person.01265164010.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265164010.29"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Ho", 
            "givenName": "I-Cheng", 
            "id": "sg:person.0764577653.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764577653.99"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Sharpe", 
            "givenName": "Arlene H", 
            "id": "sg:person.01251025322.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251025322.55"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Kuchroo", 
            "givenName": "Vijay K", 
            "id": "sg:person.0700425476.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700425476.95"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature01355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001374380", 
              "https://doi.org/10.1038/nature01355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002269423", 
              "https://doi.org/10.1038/ni1488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.iy.12.040194.001001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003118210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200636484", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005805255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.177.7.4927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006564372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35051107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009086703", 
              "https://doi.org/10.1038/35051107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35051107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009086703", 
              "https://doi.org/10.1038/35051107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2006.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009201806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20061660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010191969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.190.8.1123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010676566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.193.12.1373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011339055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20041257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013395893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013715729", 
              "https://doi.org/10.1038/nri2097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013972387", 
              "https://doi.org/10.1038/nature03555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013972387", 
              "https://doi.org/10.1038/nature03555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200636136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014552785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016533429", 
              "https://doi.org/10.1038/nature06253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20020632", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017876515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0502-500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017909088", 
              "https://doi.org/10.1038/nm0502-500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0502-500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017909088", 
              "https://doi.org/10.1038/nm0502-500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200636138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018012799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.192.11.1553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021344568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023001086", 
              "https://doi.org/10.1038/ni947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023001086", 
              "https://doi.org/10.1038/ni947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m207577200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026977842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80432-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029071855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35051100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029587160", 
              "https://doi.org/10.1038/35051100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35051100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029587160", 
              "https://doi.org/10.1038/35051100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.175.4.2340", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029773796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030750872", 
              "https://doi.org/10.1038/ni1261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030750872", 
              "https://doi.org/10.1038/ni1261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/89731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032717308", 
              "https://doi.org/10.1038/89731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/89731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032717308", 
              "https://doi.org/10.1038/89731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(03)00144-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033539397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05970", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035445598", 
              "https://doi.org/10.1038/nature05970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/135245859900500206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036705868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/135245859900500206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036705868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/135245859900500206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036705868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037247321", 
              "https://doi.org/10.1038/nature04753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037247321", 
              "https://doi.org/10.1038/nature04753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-08-2416", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038056272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038439169", 
              "https://doi.org/10.1038/ni902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038439169", 
              "https://doi.org/10.1038/ni902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038491172", 
              "https://doi.org/10.1038/ni1552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)00011-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038551385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.177.1.566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040036581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/immu.200310013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041785172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/89709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043850653", 
              "https://doi.org/10.1038/89709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/89709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043850653", 
              "https://doi.org/10.1038/89709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1747.1998.00347.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045568153", 
              "https://doi.org/10.1046/j.1523-1747.1998.00347.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/16717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046244067", 
              "https://doi.org/10.1038/16717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/16717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046244067", 
              "https://doi.org/10.1038/16717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.07.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046724496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-07-2955", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050105372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.179.12.8180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050784974"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/39614", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053642209", 
              "https://doi.org/10.1038/39614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/39614", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053642209", 
              "https://doi.org/10.1038/39614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1191/135245899678847275", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064157533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.166.6.3659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074780127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.168.3.991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074984103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.171.11.6173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076602214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.173.1.68", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076855486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083390095", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-02", 
        "datePublishedReg": "2009-02-01", 
        "description": "The inducible costimulatory molecule ICOS has been suggested to be important in the development of interleukin 17 (IL-17)-producing helper T cells (T(H)-17 cells) and of follicular helper T cells (T(FH) cells). Here we show that ICOS-deficient mice had no defect in T(H)-17 differentiation but had fewer T(H)-17 cells after IL-23 stimulation and fewer T(FH) cells. We also show that T(FH) cells produced IL-17 and that T(FH) cells in ICOS-deficient mice were defective in IL-17 production. Both T(H)-17 and T(FH) cells had higher expression of the transcription factor c-Maf. Genetic loss of c-Maf resulted in a defect in IL-21 production and fewer T(H)-17 and T(FH) cells. Thus our data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of T(H)-17 and T(FH) cells.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ni.1690", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2560720", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2454480", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2558363", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2633952", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2437405", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2435119", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2636123", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2560640", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2434988", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1022778", 
            "issn": [
              "1529-2908", 
              "1529-2916"
            ], 
            "name": "Nature Immunology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells", 
        "pagination": "167-175", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d3e8eac28946fc3c0947f79d3ad5fcfa05c78b620272602499f7831fa46a42c9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19098919"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100941354"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ni.1690"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1044487288"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ni.1690", 
          "https://app.dimensions.ai/details/publication/pub.1044487288"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:45", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000426.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/ni/journal/v10/n2/full/ni.1690.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ni.1690'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni.1690'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ni.1690'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni.1690'


     

    This table displays all metadata directly associated to this object as RDF triples.

    363 TRIPLES      21 PREDICATES      97 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ni.1690 schema:about N068f6f1fc34c4d529747a44290b0c8cb
    2 N0b699d1b0d6f4454a0f951ff98eee079
    3 N0f2913ec20004ab684590fa6dec1f131
    4 N180e99b5f156469a99c0b48214940e04
    5 N1c4c7e0cc1654e869ced185422394068
    6 N24b6842ebf4045678d52ca8f4a7583df
    7 N3af12c992e0a427b983b5b04d884db31
    8 N3b368c57fefe43acaf6abb5052b98410
    9 N4563ec6df39a48f3b4558613bd4ec941
    10 N513406fe3bf841e0873bfefc66d8636a
    11 N7a2d214716224354990032e8b5f9307e
    12 N8087a51a95f44d07a14c1cd414c43a0b
    13 N8896c13d39b647cc8114964cb61d505c
    14 N92b6a9d4eb4a43b0893e0369d5e02b11
    15 N9a5c47f8ffec4d6d832d701c2f1bcd93
    16 Nd3a5518295ca4900ae78035413955701
    17 Ne63e72664d264d258b188ff7709c8ecf
    18 Nfa4fcb8bfcfc4021bfecc97337eed43f
    19 anzsrc-for:11
    20 anzsrc-for:1107
    21 schema:author Nc6397afc4f6d473f88a4ef209c7c39d3
    22 schema:citation sg:pub.10.1038/16717
    23 sg:pub.10.1038/35051100
    24 sg:pub.10.1038/35051107
    25 sg:pub.10.1038/39614
    26 sg:pub.10.1038/89709
    27 sg:pub.10.1038/89731
    28 sg:pub.10.1038/nature01355
    29 sg:pub.10.1038/nature03555
    30 sg:pub.10.1038/nature04753
    31 sg:pub.10.1038/nature04754
    32 sg:pub.10.1038/nature05970
    33 sg:pub.10.1038/nature06253
    34 sg:pub.10.1038/ni1261
    35 sg:pub.10.1038/ni1488
    36 sg:pub.10.1038/ni1552
    37 sg:pub.10.1038/ni902
    38 sg:pub.10.1038/ni947
    39 sg:pub.10.1038/nm0502-500
    40 sg:pub.10.1038/nri2097
    41 sg:pub.10.1046/j.1523-1747.1998.00347.x
    42 https://app.dimensions.ai/details/publication/pub.1083390095
    43 https://doi.org/10.1002/eji.200636136
    44 https://doi.org/10.1002/eji.200636138
    45 https://doi.org/10.1002/eji.200636484
    46 https://doi.org/10.1002/immu.200310013
    47 https://doi.org/10.1016/j.cell.2006.07.035
    48 https://doi.org/10.1016/j.immuni.2006.01.001
    49 https://doi.org/10.1016/s1074-7613(00)00011-x
    50 https://doi.org/10.1016/s1074-7613(00)80432-x
    51 https://doi.org/10.1016/s1074-7613(03)00144-4
    52 https://doi.org/10.1074/jbc.m207577200
    53 https://doi.org/10.1084/jem.190.8.1123
    54 https://doi.org/10.1084/jem.192.11.1553
    55 https://doi.org/10.1084/jem.193.12.1373
    56 https://doi.org/10.1084/jem.20020632
    57 https://doi.org/10.1084/jem.20041257
    58 https://doi.org/10.1084/jem.20061660
    59 https://doi.org/10.1146/annurev.iy.12.040194.001001
    60 https://doi.org/10.1177/135245859900500206
    61 https://doi.org/10.1182/blood-2002-08-2416
    62 https://doi.org/10.1182/blood-2005-07-2955
    63 https://doi.org/10.1191/135245899678847275
    64 https://doi.org/10.4049/jimmunol.166.6.3659
    65 https://doi.org/10.4049/jimmunol.168.3.991
    66 https://doi.org/10.4049/jimmunol.171.11.6173
    67 https://doi.org/10.4049/jimmunol.173.1.68
    68 https://doi.org/10.4049/jimmunol.175.4.2340
    69 https://doi.org/10.4049/jimmunol.177.1.566
    70 https://doi.org/10.4049/jimmunol.177.7.4927
    71 https://doi.org/10.4049/jimmunol.179.12.8180
    72 schema:datePublished 2009-02
    73 schema:datePublishedReg 2009-02-01
    74 schema:description The inducible costimulatory molecule ICOS has been suggested to be important in the development of interleukin 17 (IL-17)-producing helper T cells (T(H)-17 cells) and of follicular helper T cells (T(FH) cells). Here we show that ICOS-deficient mice had no defect in T(H)-17 differentiation but had fewer T(H)-17 cells after IL-23 stimulation and fewer T(FH) cells. We also show that T(FH) cells produced IL-17 and that T(FH) cells in ICOS-deficient mice were defective in IL-17 production. Both T(H)-17 and T(FH) cells had higher expression of the transcription factor c-Maf. Genetic loss of c-Maf resulted in a defect in IL-21 production and fewer T(H)-17 and T(FH) cells. Thus our data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of T(H)-17 and T(FH) cells.
    75 schema:genre research_article
    76 schema:inLanguage en
    77 schema:isAccessibleForFree true
    78 schema:isPartOf N5db2609184c04afe91c60769711fd3b6
    79 Nb642d37fe1d94662acc2bd7d16703c9a
    80 sg:journal.1022778
    81 schema:name The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    82 schema:pagination 167-175
    83 schema:productId N560c228b39804ac4bc2941f22a36b606
    84 N797d19d031b64c51aec155753947f6e7
    85 Nb4b6d36b3ed349ac9cdfa8ecce04d04c
    86 Nccbee6180978430393f5b66c8d125baf
    87 Nd8b44cb3a1c347fba6fd69521c845cdd
    88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044487288
    89 https://doi.org/10.1038/ni.1690
    90 schema:sdDatePublished 2019-04-10T19:45
    91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    92 schema:sdPublisher Ncced46b5193448ad84b0767366215c8b
    93 schema:url http://www.nature.com/ni/journal/v10/n2/full/ni.1690.html
    94 sgo:license sg:explorer/license/
    95 sgo:sdDataset articles
    96 rdf:type schema:ScholarlyArticle
    97 N068f6f1fc34c4d529747a44290b0c8cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Interleukin-17
    99 rdf:type schema:DefinedTerm
    100 N07121b3d5904466dbbd709cf545b2e0b rdf:first sg:person.0700425476.95
    101 rdf:rest rdf:nil
    102 N0b699d1b0d6f4454a0f951ff98eee079 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Antigens, Differentiation, T-Lymphocyte
    104 rdf:type schema:DefinedTerm
    105 N0f2913ec20004ab684590fa6dec1f131 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Mice, Transgenic
    107 rdf:type schema:DefinedTerm
    108 N180e99b5f156469a99c0b48214940e04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Oligonucleotide Array Sequence Analysis
    110 rdf:type schema:DefinedTerm
    111 N1c4c7e0cc1654e869ced185422394068 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name T-Lymphocyte Subsets
    113 rdf:type schema:DefinedTerm
    114 N24b6842ebf4045678d52ca8f4a7583df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Flow Cytometry
    116 rdf:type schema:DefinedTerm
    117 N36df99e31b844fee9aee28172866ef0f schema:name Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
    118 rdf:type schema:Organization
    119 N3af12c992e0a427b983b5b04d884db31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Interleukins
    121 rdf:type schema:DefinedTerm
    122 N3b368c57fefe43acaf6abb5052b98410 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Reverse Transcriptase Polymerase Chain Reaction
    124 rdf:type schema:DefinedTerm
    125 N4563ec6df39a48f3b4558613bd4ec941 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Cell Proliferation
    127 rdf:type schema:DefinedTerm
    128 N4cad445e5daf43849788b358cd39e340 rdf:first sg:person.011171115467.83
    129 rdf:rest N9f92c8e0face49b3acbe338b72063387
    130 N513406fe3bf841e0873bfefc66d8636a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Animals
    132 rdf:type schema:DefinedTerm
    133 N560c228b39804ac4bc2941f22a36b606 schema:name dimensions_id
    134 schema:value pub.1044487288
    135 rdf:type schema:PropertyValue
    136 N5db2609184c04afe91c60769711fd3b6 schema:volumeNumber 10
    137 rdf:type schema:PublicationVolume
    138 N797d19d031b64c51aec155753947f6e7 schema:name readcube_id
    139 schema:value d3e8eac28946fc3c0947f79d3ad5fcfa05c78b620272602499f7831fa46a42c9
    140 rdf:type schema:PropertyValue
    141 N7a2d214716224354990032e8b5f9307e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Gene Expression Regulation
    143 rdf:type schema:DefinedTerm
    144 N8087a51a95f44d07a14c1cd414c43a0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Enzyme-Linked Immunosorbent Assay
    146 rdf:type schema:DefinedTerm
    147 N8896c13d39b647cc8114964cb61d505c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Mice
    149 rdf:type schema:DefinedTerm
    150 N8e4a8eb571484c708da31f060797bff7 rdf:first sg:person.01251025322.55
    151 rdf:rest N07121b3d5904466dbbd709cf545b2e0b
    152 N92b6a9d4eb4a43b0893e0369d5e02b11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name T-Lymphocytes, Helper-Inducer
    154 rdf:type schema:DefinedTerm
    155 N9a5c47f8ffec4d6d832d701c2f1bcd93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Cell Differentiation
    157 rdf:type schema:DefinedTerm
    158 N9f92c8e0face49b3acbe338b72063387 rdf:first sg:person.0715160101.73
    159 rdf:rest Naa0bc7aaa8a144599ca771eda159856b
    160 Naa0bc7aaa8a144599ca771eda159856b rdf:first sg:person.01265164010.29
    161 rdf:rest Nea171e346b1a44b59fd5f2249b74eafb
    162 Nb4b6d36b3ed349ac9cdfa8ecce04d04c schema:name pubmed_id
    163 schema:value 19098919
    164 rdf:type schema:PropertyValue
    165 Nb642d37fe1d94662acc2bd7d16703c9a schema:issueNumber 2
    166 rdf:type schema:PublicationIssue
    167 Nc6397afc4f6d473f88a4ef209c7c39d3 rdf:first sg:person.01200406751.16
    168 rdf:rest N4cad445e5daf43849788b358cd39e340
    169 Nccbee6180978430393f5b66c8d125baf schema:name nlm_unique_id
    170 schema:value 100941354
    171 rdf:type schema:PropertyValue
    172 Ncced46b5193448ad84b0767366215c8b schema:name Springer Nature - SN SciGraph project
    173 rdf:type schema:Organization
    174 Nd3a5518295ca4900ae78035413955701 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Inducible T-Cell Co-Stimulator Protein
    176 rdf:type schema:DefinedTerm
    177 Nd8b44cb3a1c347fba6fd69521c845cdd schema:name doi
    178 schema:value 10.1038/ni.1690
    179 rdf:type schema:PropertyValue
    180 Ne63e72664d264d258b188ff7709c8ecf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Proto-Oncogene Proteins c-maf
    182 rdf:type schema:DefinedTerm
    183 Nea171e346b1a44b59fd5f2249b74eafb rdf:first sg:person.0764577653.99
    184 rdf:rest N8e4a8eb571484c708da31f060797bff7
    185 Nfa4fcb8bfcfc4021bfecc97337eed43f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Encephalomyelitis, Autoimmune, Experimental
    187 rdf:type schema:DefinedTerm
    188 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    189 schema:name Medical and Health Sciences
    190 rdf:type schema:DefinedTerm
    191 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    192 schema:name Immunology
    193 rdf:type schema:DefinedTerm
    194 sg:grant.2434988 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1690
    195 rdf:type schema:MonetaryGrant
    196 sg:grant.2435119 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1690
    197 rdf:type schema:MonetaryGrant
    198 sg:grant.2437405 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1690
    199 rdf:type schema:MonetaryGrant
    200 sg:grant.2454480 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1690
    201 rdf:type schema:MonetaryGrant
    202 sg:grant.2558363 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1690
    203 rdf:type schema:MonetaryGrant
    204 sg:grant.2560640 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1690
    205 rdf:type schema:MonetaryGrant
    206 sg:grant.2560720 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1690
    207 rdf:type schema:MonetaryGrant
    208 sg:grant.2633952 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1690
    209 rdf:type schema:MonetaryGrant
    210 sg:grant.2636123 http://pending.schema.org/fundedItem sg:pub.10.1038/ni.1690
    211 rdf:type schema:MonetaryGrant
    212 sg:journal.1022778 schema:issn 1529-2908
    213 1529-2916
    214 schema:name Nature Immunology
    215 rdf:type schema:Periodical
    216 sg:person.011171115467.83 schema:familyName Jin
    217 schema:givenName Hulin
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011171115467.83
    219 rdf:type schema:Person
    220 sg:person.01200406751.16 schema:affiliation N36df99e31b844fee9aee28172866ef0f
    221 schema:familyName Bauquet
    222 schema:givenName Aurelie T
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200406751.16
    224 rdf:type schema:Person
    225 sg:person.01251025322.55 schema:familyName Sharpe
    226 schema:givenName Arlene H
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251025322.55
    228 rdf:type schema:Person
    229 sg:person.01265164010.29 schema:familyName Mitsdoerffer
    230 schema:givenName Meike
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265164010.29
    232 rdf:type schema:Person
    233 sg:person.0700425476.95 schema:familyName Kuchroo
    234 schema:givenName Vijay K
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700425476.95
    236 rdf:type schema:Person
    237 sg:person.0715160101.73 schema:familyName Paterson
    238 schema:givenName Alison M
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715160101.73
    240 rdf:type schema:Person
    241 sg:person.0764577653.99 schema:familyName Ho
    242 schema:givenName I-Cheng
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764577653.99
    244 rdf:type schema:Person
    245 sg:pub.10.1038/16717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046244067
    246 https://doi.org/10.1038/16717
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/35051100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029587160
    249 https://doi.org/10.1038/35051100
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/35051107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009086703
    252 https://doi.org/10.1038/35051107
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/39614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053642209
    255 https://doi.org/10.1038/39614
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/89709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043850653
    258 https://doi.org/10.1038/89709
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/89731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032717308
    261 https://doi.org/10.1038/89731
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/nature01355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001374380
    264 https://doi.org/10.1038/nature01355
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/nature03555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013972387
    267 https://doi.org/10.1038/nature03555
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/nature04753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037247321
    270 https://doi.org/10.1038/nature04753
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/nature04754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043278106
    273 https://doi.org/10.1038/nature04754
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nature05970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035445598
    276 https://doi.org/10.1038/nature05970
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nature06253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016533429
    279 https://doi.org/10.1038/nature06253
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/ni1261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030750872
    282 https://doi.org/10.1038/ni1261
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/ni1488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002269423
    285 https://doi.org/10.1038/ni1488
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/ni1552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038491172
    288 https://doi.org/10.1038/ni1552
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/ni902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038439169
    291 https://doi.org/10.1038/ni902
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/ni947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023001086
    294 https://doi.org/10.1038/ni947
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/nm0502-500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017909088
    297 https://doi.org/10.1038/nm0502-500
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/nri2097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013715729
    300 https://doi.org/10.1038/nri2097
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1046/j.1523-1747.1998.00347.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045568153
    303 https://doi.org/10.1046/j.1523-1747.1998.00347.x
    304 rdf:type schema:CreativeWork
    305 https://app.dimensions.ai/details/publication/pub.1083390095 schema:CreativeWork
    306 https://doi.org/10.1002/eji.200636136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014552785
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1002/eji.200636138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018012799
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1002/eji.200636484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005805255
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1002/immu.200310013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041785172
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/j.cell.2006.07.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046724496
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/j.immuni.2006.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009201806
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/s1074-7613(00)00011-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038551385
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/s1074-7613(00)80432-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029071855
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/s1074-7613(03)00144-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033539397
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1074/jbc.m207577200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026977842
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1084/jem.190.8.1123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010676566
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1084/jem.192.11.1553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021344568
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1084/jem.193.12.1373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011339055
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1084/jem.20020632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017876515
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1084/jem.20041257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013395893
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1084/jem.20061660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010191969
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1146/annurev.iy.12.040194.001001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003118210
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1177/135245859900500206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036705868
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1182/blood-2002-08-2416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038056272
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1182/blood-2005-07-2955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050105372
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1191/135245899678847275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064157533
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.4049/jimmunol.166.6.3659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074780127
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.4049/jimmunol.168.3.991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074984103
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.4049/jimmunol.171.11.6173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076602214
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.4049/jimmunol.173.1.68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076855486
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.4049/jimmunol.175.4.2340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029773796
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.4049/jimmunol.177.1.566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040036581
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.4049/jimmunol.177.7.4927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006564372
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.4049/jimmunol.179.12.8180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050784974
    363 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...