The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02

AUTHORS

Aurelie T Bauquet, Hulin Jin, Alison M Paterson, Meike Mitsdoerffer, I-Cheng Ho, Arlene H Sharpe, Vijay K Kuchroo

ABSTRACT

The inducible costimulatory molecule ICOS has been suggested to be important in the development of interleukin 17 (IL-17)-producing helper T cells (T(H)-17 cells) and of follicular helper T cells (T(FH) cells). Here we show that ICOS-deficient mice had no defect in T(H)-17 differentiation but had fewer T(H)-17 cells after IL-23 stimulation and fewer T(FH) cells. We also show that T(FH) cells produced IL-17 and that T(FH) cells in ICOS-deficient mice were defective in IL-17 production. Both T(H)-17 and T(FH) cells had higher expression of the transcription factor c-Maf. Genetic loss of c-Maf resulted in a defect in IL-21 production and fewer T(H)-17 and T(FH) cells. Thus our data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of T(H)-17 and T(FH) cells. More... »

PAGES

167-175

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni.1690

    DOI

    http://dx.doi.org/10.1038/ni.1690

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044487288

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19098919


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