Parameters for reliable results in genetic association studies in common disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-01-22

AUTHORS

Ingrid Dahlman, Iain A. Eaves, Roman Kosoy, V. Anne Morrison, Joanne Heward, Stephen C.L. Gough, Amit Allahabadia, Jayne A. Franklyn, Jaakko Tuomilehto, Eva Tuomilehto-Wolf, Francesco Cucca, Cristian Guja, Constantin Ionescu-Tirgoviste, Helen Stevens, Philippa Carr, Sarah Nutland, Patricia McKinney, Julian P. Shield, William Wang, Heather J. Cordell, Neil Walker, John A. Todd, Patrick Concannon

ABSTRACT

It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable. More... »

PAGES

149-150

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng825

DOI

http://dx.doi.org/10.1038/ng825

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013433302

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11799396


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N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng825'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng825'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng825'


 

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