Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-07

AUTHORS

John A Todd, Neil M Walker, Jason D Cooper, Deborah J Smyth, Kate Downes, Vincent Plagnol, Rebecca Bailey, Sergey Nejentsev, Sarah F Field, Felicity Payne, Christopher E Lowe, Jeffrey S Szeszko, Jason P Hafler, Lauren Zeitels, Jennie H M Yang, Adrian Vella, Sarah Nutland, Helen E Stevens, Helen Schuilenburg, Gillian Coleman, Meeta Maisuria, William Meadows, Luc J Smink, Barry Healy, Oliver S Burren, Alex A C Lam, Nigel R Ovington, James Allen, Ellen Adlem, Hin-Tak Leung, Chris Wallace, Joanna M M Howson, Cristian Guja, Constantin Ionescu-Tîrgovişte, Matthew J Simmonds, Joanne M Heward, Stephen C L Gough, David B Dunger, Linda S Wicker, David G Clayton

ABSTRACT

The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows associations at P < 5 x 10(-7) between T1D and six chromosome regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27. Here, we attempted to validate these and six other top findings in 4,000 individuals with T1D, 5,000 controls and 2,997 family trios independent of the WTCCC study. We confirmed unequivocally the associations of 12q24, 12q13, 16p13 and 18p11 (P(follow-up) More... »

PAGES

857-864

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng2068

DOI

http://dx.doi.org/10.1038/ng2068

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049634155

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17554260


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