Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-07

AUTHORS

Miles Parkes, Jeffrey C Barrett, Natalie J Prescott, Mark Tremelling, Carl A Anderson, Sheila A Fisher, Roland G Roberts, Elaine R Nimmo, Fraser R Cummings, Dianne Soars, Hazel Drummond, Charlie W Lees, Saud A Khawaja, Richard Bagnall, Denis A Burke, Catherine E Todhunter, Tariq Ahmad, Clive M Onnie, Wendy McArdle, David Strachan, Graeme Bethel, Claire Bryan, Cathryn M Lewis, Panos Deloukas, Alastair Forbes, Jeremy Sanderson, Derek P Jewell, Jack Satsangi, John C Mansfield, Lon Cardon, Christopher G Mathew

ABSTRACT

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13. More... »

PAGES

830-832

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng2061

DOI

http://dx.doi.org/10.1038/ng2061

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032812994

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17554261


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