Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-05

AUTHORS

Idoya Lahortiga, Kim De Keersmaecker, Pieter Van Vlierberghe, Carlos Graux, Barbara Cauwelier, Frederic Lambert, Nicole Mentens, H Berna Beverloo, Rob Pieters, Frank Speleman, Maria D Odero, Marijke Bauters, Guy Froyen, Peter Marynen, Peter Vandenberghe, Iwona Wlodarska, Jules P P Meijerink, Jan Cools

ABSTRACT

We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL. More... »

PAGES

593-595

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng2025

DOI

http://dx.doi.org/10.1038/ng2025

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025795238

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17435759


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312 https://www.grid.ac/institutes/grid.4861.b schema:alternateName University of Liège
313 schema:name Department of Human Genetics, Center for Biomedical Integrated Genoproteomics, University of Liège, Belgium.
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315 https://www.grid.ac/institutes/grid.5596.f schema:alternateName KU Leuven
316 schema:name Human Genome Laboratory, Center for Human Genetics, Katholieke Universiteit (K.U.) Leuven, Leuven, Belgium.
317 Human Genome Laboratory, Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium.
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319 https://www.grid.ac/institutes/grid.5645.2 schema:alternateName Erasmus University Medical Center
320 schema:name Department of Clinical Genetics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
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322 https://www.grid.ac/institutes/grid.5924.a schema:alternateName University of Navarra
323 schema:name Division of Oncology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.
324 Human Genome Laboratory, Center for Human Genetics, Katholieke Universiteit (K.U.) Leuven, Leuven, Belgium.
325 Human Genome Laboratory, Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium.
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327 https://www.grid.ac/institutes/grid.7942.8 schema:alternateName Université Catholique de Louvain
328 schema:name Department of Hematology, Cliniques Universitaires UCL (Université Catholique de Louvain) Mont-Godinne, Yvoir, Belgium.
329 Human Genome Laboratory, Center for Human Genetics, Katholieke Universiteit (K.U.) Leuven, Leuven, Belgium.
330 Human Genome Laboratory, Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium.
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