Genetic reconstruction of a functional transcriptional regulatory network View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-05

AUTHORS

Zhanzhi Hu, Patrick J Killion, Vishwanath R Iyer

ABSTRACT

Although global analyses of transcription factor binding provide one view of potential transcriptional regulatory networks, regulation also occurs at levels distinct from transcription factor binding. Here, we use a genetic approach to identify targets of transcription factors in yeast and reconstruct a functional regulatory network. First, we profiled transcriptional responses in S. cerevisiae strains with individual deletions of 263 transcription factors. Then we used directed-weighted graph modeling and regulatory epistasis analysis to identify indirect regulatory relationships between these transcription factors, and from this we reconstructed a functional transcriptional regulatory network. The enrichment of promoter motifs and Gene Ontology annotations provide insight into the biological functions of the transcription factors. More... »

PAGES

683-687

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng2012

DOI

http://dx.doi.org/10.1038/ng2012

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005200656

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17417638


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