Common genetic variants account for differences in gene expression among ethnic groups View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-02

AUTHORS

Richard S Spielman, Laurel A Bastone, Joshua T Burdick, Michael Morley, Warren J Ewens, Vivian G Cheung

ABSTRACT

Variation in DNA sequence contributes to individual differences in quantitative traits, but in humans the specific sequence variants are known for very few traits. We characterized variation in gene expression in cells from individuals belonging to three major population groups. This quantitative phenotype differs significantly between European-derived and Asian-derived populations for 1,097 of 4,197 genes tested. For the phenotypes with the strongest evidence of cis determinants, most of the variation is due to allele frequency differences at cis-linked regulators. The results show that specific genetic variation among populations contributes appreciably to differences in gene expression phenotypes. Populations differ in prevalence of many complex genetic diseases, such as diabetes and cardiovascular disease. As some of these are probably influenced by the level of gene expression, our results suggest that allele frequency differences at regulatory polymorphisms also account for some population differences in prevalence of complex diseases. More... »

PAGES

226-231

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1955

DOI

http://dx.doi.org/10.1038/ng1955

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051601706

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17206142


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