Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription View Full Text


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Article Info

DATE

2007-01

AUTHORS

Daniel Zilberman, Mary Gehring, Robert K Tran, Tracy Ballinger, Steven Henikoff

ABSTRACT

Cytosine methylation, a common form of DNA modification that antagonizes transcription, is found at transposons and repeats in vertebrates, plants and fungi. Here we have mapped DNA methylation in the entire Arabidopsis thaliana genome at high resolution. DNA methylation covers transposons and is present within a large fraction of A. thaliana genes. Methylation within genes is conspicuously biased away from gene ends, suggesting a dependence on RNA polymerase transit. Genic methylation is strongly influenced by transcription: moderately transcribed genes are most likely to be methylated, whereas genes at either extreme are least likely. In turn, transcription is influenced by methylation: short methylated genes are poorly expressed, and loss of methylation in the body of a gene leads to enhanced transcription. Our results indicate that genic transcription and DNA methylation are closely interwoven processes. More... »

PAGES

61-69

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1929

DOI

http://dx.doi.org/10.1038/ng1929

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036244128

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17128275


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