Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-08

AUTHORS

Fabienne Cléard, Yuri Moshkin, François Karch, Robert K Maeda

ABSTRACT

A cis-regulatory region of nearly 300 kb controls the expression of the three bithorax complex (BX-C) homeotic genes: Ubx, abd-A and Abd-B. Interspersed between the numerous enhancers and silencers within the complex are elements called domain boundaries. Recently, many pieces of evidence have suggested that boundaries function to create autonomous domains by interacting among themselves and forming chromatin loops. In order to test this hypothesis, we used Dam identification to probe for interactions between the Fab-7 boundary and other regions in the BX-C. We were surprised to find that the targeting of Dam methyltransferase (Dam) to the Fab-7 boundary results in a strong methylation signal at the Abd-Bm promoter, approximately 35 kb away. Moreover, this methylation pattern is found primarily in the tissues where Abd-B is not expressed and requires an intact Fab-7 boundary. Overall, our work provides the first documented example of a dynamic, long-distance physical interaction between distal regulatory elements within a living, multicellular organism. More... »

PAGES

931-935

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1833

DOI

http://dx.doi.org/10.1038/ng1833

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035014811

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16823379


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0806", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Information Systems", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/08", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Information and Computing Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Genetically Modified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila melanogaster", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Homeobox", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Insect", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Regulator", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multigene Family", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Site-Specific DNA-Methyltransferase (Adenine-Specific)", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Geneva", 
          "id": "https://www.grid.ac/institutes/grid.8591.5", 
          "name": [
            "Department of Zoology and Animal Biology and National Research Center Frontiers in Genetics, University of Geneva, 30 quai E. Ansermet, 1211 Geneva-4, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cl\u00e9ard", 
        "givenName": "Fabienne", 
        "id": "sg:person.01344047055.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344047055.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Erasmus University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5645.2", 
          "name": [
            "Department of Biochemistry, Erasmus University Medical Centre, Dr. Molewaterplein 50, 3015 Rotterdam, The Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moshkin", 
        "givenName": "Yuri", 
        "id": "sg:person.0774232717.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774232717.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Geneva", 
          "id": "https://www.grid.ac/institutes/grid.8591.5", 
          "name": [
            "Department of Zoology and Animal Biology and National Research Center Frontiers in Genetics, University of Geneva, 30 quai E. Ansermet, 1211 Geneva-4, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karch", 
        "givenName": "Fran\u00e7ois", 
        "id": "sg:person.01343043402.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343043402.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Geneva", 
          "id": "https://www.grid.ac/institutes/grid.8591.5", 
          "name": [
            "Department of Zoology and Animal Biology and National Research Center Frontiers in Genetics, University of Geneva, 30 quai E. Ansermet, 1211 Geneva-4, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maeda", 
        "givenName": "Robert K", 
        "id": "sg:person.0666556155.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666556155.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)00101-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004934399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.291.5503.493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007454261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2005.08.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008123566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2005.08.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008123566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/276565a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009007731", 
          "https://doi.org/10.1038/276565a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.10.24.3195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009273629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.291.5503.495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025624690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.18.8398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027632558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(01)00377-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028548910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.10.24.3202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031200637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81546-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035294751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.22.12418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036456426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/74487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036546793", 
          "https://doi.org/10.1038/74487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/74487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036546793", 
          "https://doi.org/10.1038/74487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.25.9.3682-3689.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038001294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/85871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044489600", 
          "https://doi.org/10.1038/85871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/85871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044489600", 
          "https://doi.org/10.1038/85871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.23.5.1498-1508.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046721823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s000180050125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050489380", 
          "https://doi.org/10.1007/s000180050125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.269503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051624170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.02323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053379290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074478941", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074543945", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074581517", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074687943", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1990.tb07439.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077953510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1990.tb07876.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078571624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1989.tb08408.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079051393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082526099", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1993.tb05750.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082784708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082988316", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083095162", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083271393", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-08", 
    "datePublishedReg": "2006-08-01", 
    "description": "A cis-regulatory region of nearly 300 kb controls the expression of the three bithorax complex (BX-C) homeotic genes: Ubx, abd-A and Abd-B. Interspersed between the numerous enhancers and silencers within the complex are elements called domain boundaries. Recently, many pieces of evidence have suggested that boundaries function to create autonomous domains by interacting among themselves and forming chromatin loops. In order to test this hypothesis, we used Dam identification to probe for interactions between the Fab-7 boundary and other regions in the BX-C. We were surprised to find that the targeting of Dam methyltransferase (Dam) to the Fab-7 boundary results in a strong methylation signal at the Abd-Bm promoter, approximately 35 kb away. Moreover, this methylation pattern is found primarily in the tissues where Abd-B is not expressed and requires an intact Fab-7 boundary. Overall, our work provides the first documented example of a dynamic, long-distance physical interaction between distal regulatory elements within a living, multicellular organism.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ng1833", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "name": "Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification", 
    "pagination": "931-935", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a6cc39448502e4ab63e8a56f12d624bd6c7e63b95a3230cad933bb0c4f047197"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16823379"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9216904"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng1833"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035014811"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng1833", 
      "https://app.dimensions.ai/details/publication/pub.1035014811"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87083_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/ng1833"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng1833'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng1833'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng1833'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng1833'


 

This table displays all metadata directly associated to this object as RDF triples.

215 TRIPLES      21 PREDICATES      68 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng1833 schema:about N1245787d18f74060883ce5bfc33a0a26
2 N2393617ce5af42a68a72a70e2e5aec98
3 N8f2c285e4e044ce185493296f90304e6
4 N95da5b2f53a846c2a02b2c844d422094
5 Naeef25592f244f35b06e95a719ee50a1
6 Nb1fd5d5530b540d690969e15caa3625a
7 Nc58517cd5cdc4160866408d6d8a22b66
8 Nf2d3f355ff884c6b8d6af51f1544591e
9 Nfe665ddb87ca4b52a3d1432359cfdbc5
10 anzsrc-for:08
11 anzsrc-for:0806
12 schema:author N670093346dac4edfa80c00c500dd2ed0
13 schema:citation sg:pub.10.1007/s000180050125
14 sg:pub.10.1038/276565a0
15 sg:pub.10.1038/74487
16 sg:pub.10.1038/85871
17 https://app.dimensions.ai/details/publication/pub.1074478941
18 https://app.dimensions.ai/details/publication/pub.1074543945
19 https://app.dimensions.ai/details/publication/pub.1074581517
20 https://app.dimensions.ai/details/publication/pub.1074687943
21 https://app.dimensions.ai/details/publication/pub.1082526099
22 https://app.dimensions.ai/details/publication/pub.1082988316
23 https://app.dimensions.ai/details/publication/pub.1083095162
24 https://app.dimensions.ai/details/publication/pub.1083271393
25 https://doi.org/10.1002/j.1460-2075.1989.tb08408.x
26 https://doi.org/10.1002/j.1460-2075.1990.tb07439.x
27 https://doi.org/10.1002/j.1460-2075.1990.tb07876.x
28 https://doi.org/10.1002/j.1460-2075.1993.tb05750.x
29 https://doi.org/10.1016/j.ydbio.2005.08.025
30 https://doi.org/10.1016/s0092-8674(00)81546-9
31 https://doi.org/10.1016/s1097-2765(00)00101-5
32 https://doi.org/10.1016/s1097-2765(01)00377-x
33 https://doi.org/10.1073/pnas.92.18.8398
34 https://doi.org/10.1073/pnas.93.22.12418
35 https://doi.org/10.1101/gad.10.24.3195
36 https://doi.org/10.1101/gad.10.24.3202
37 https://doi.org/10.1101/gad.269503
38 https://doi.org/10.1126/science.291.5503.493
39 https://doi.org/10.1126/science.291.5503.495
40 https://doi.org/10.1128/mcb.23.5.1498-1508.2003
41 https://doi.org/10.1128/mcb.25.9.3682-3689.2005
42 https://doi.org/10.1242/dev.02323
43 schema:datePublished 2006-08
44 schema:datePublishedReg 2006-08-01
45 schema:description A cis-regulatory region of nearly 300 kb controls the expression of the three bithorax complex (BX-C) homeotic genes: Ubx, abd-A and Abd-B. Interspersed between the numerous enhancers and silencers within the complex are elements called domain boundaries. Recently, many pieces of evidence have suggested that boundaries function to create autonomous domains by interacting among themselves and forming chromatin loops. In order to test this hypothesis, we used Dam identification to probe for interactions between the Fab-7 boundary and other regions in the BX-C. We were surprised to find that the targeting of Dam methyltransferase (Dam) to the Fab-7 boundary results in a strong methylation signal at the Abd-Bm promoter, approximately 35 kb away. Moreover, this methylation pattern is found primarily in the tissues where Abd-B is not expressed and requires an intact Fab-7 boundary. Overall, our work provides the first documented example of a dynamic, long-distance physical interaction between distal regulatory elements within a living, multicellular organism.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree false
49 schema:isPartOf N0e538eb9d649480089861bf88cdbc200
50 Na55dccda17c64d94a5c6f4ecfc10a27c
51 sg:journal.1103138
52 schema:name Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification
53 schema:pagination 931-935
54 schema:productId N188cdd80cf6b4dfaac4bb2a27ac4b6e1
55 N211815b2ada240f7b0355ee7d2c2b640
56 N23e185a1d6ca4629b755469cb8fb1230
57 N641a7bc8ef004907acb0f5245b1b05c4
58 Nade51c0f03c74c2dbcfa78345e412c32
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035014811
60 https://doi.org/10.1038/ng1833
61 schema:sdDatePublished 2019-04-11T12:22
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher Na66e0903ec8445d6b80bf645ff9fdea9
64 schema:url http://www.nature.com/articles/ng1833
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N0e538eb9d649480089861bf88cdbc200 schema:issueNumber 8
69 rdf:type schema:PublicationIssue
70 N1245787d18f74060883ce5bfc33a0a26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Animals
72 rdf:type schema:DefinedTerm
73 N188cdd80cf6b4dfaac4bb2a27ac4b6e1 schema:name pubmed_id
74 schema:value 16823379
75 rdf:type schema:PropertyValue
76 N211815b2ada240f7b0355ee7d2c2b640 schema:name readcube_id
77 schema:value a6cc39448502e4ab63e8a56f12d624bd6c7e63b95a3230cad933bb0c4f047197
78 rdf:type schema:PropertyValue
79 N2393617ce5af42a68a72a70e2e5aec98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Drosophila melanogaster
81 rdf:type schema:DefinedTerm
82 N23e185a1d6ca4629b755469cb8fb1230 schema:name doi
83 schema:value 10.1038/ng1833
84 rdf:type schema:PropertyValue
85 N2438808aed574d5682c8b00677a571c5 rdf:first sg:person.0774232717.13
86 rdf:rest Nc56e05131e1848c2a4541fed69fe323f
87 N641a7bc8ef004907acb0f5245b1b05c4 schema:name nlm_unique_id
88 schema:value 9216904
89 rdf:type schema:PropertyValue
90 N670093346dac4edfa80c00c500dd2ed0 rdf:first sg:person.01344047055.75
91 rdf:rest N2438808aed574d5682c8b00677a571c5
92 N72d5402f869f41d28a09dfdb2020e98f rdf:first sg:person.0666556155.32
93 rdf:rest rdf:nil
94 N8f2c285e4e044ce185493296f90304e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Genes, Insect
96 rdf:type schema:DefinedTerm
97 N95da5b2f53a846c2a02b2c844d422094 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Genes, Homeobox
99 rdf:type schema:DefinedTerm
100 Na55dccda17c64d94a5c6f4ecfc10a27c schema:volumeNumber 38
101 rdf:type schema:PublicationVolume
102 Na66e0903ec8445d6b80bf645ff9fdea9 schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 Nade51c0f03c74c2dbcfa78345e412c32 schema:name dimensions_id
105 schema:value pub.1035014811
106 rdf:type schema:PropertyValue
107 Naeef25592f244f35b06e95a719ee50a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Animals, Genetically Modified
109 rdf:type schema:DefinedTerm
110 Nb1fd5d5530b540d690969e15caa3625a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Genes, Regulator
112 rdf:type schema:DefinedTerm
113 Nc56e05131e1848c2a4541fed69fe323f rdf:first sg:person.01343043402.10
114 rdf:rest N72d5402f869f41d28a09dfdb2020e98f
115 Nc58517cd5cdc4160866408d6d8a22b66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name DNA Methylation
117 rdf:type schema:DefinedTerm
118 Nf2d3f355ff884c6b8d6af51f1544591e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Multigene Family
120 rdf:type schema:DefinedTerm
121 Nfe665ddb87ca4b52a3d1432359cfdbc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Site-Specific DNA-Methyltransferase (Adenine-Specific)
123 rdf:type schema:DefinedTerm
124 anzsrc-for:08 schema:inDefinedTermSet anzsrc-for:
125 schema:name Information and Computing Sciences
126 rdf:type schema:DefinedTerm
127 anzsrc-for:0806 schema:inDefinedTermSet anzsrc-for:
128 schema:name Information Systems
129 rdf:type schema:DefinedTerm
130 sg:journal.1103138 schema:issn 1061-4036
131 1546-1718
132 schema:name Nature Genetics
133 rdf:type schema:Periodical
134 sg:person.01343043402.10 schema:affiliation https://www.grid.ac/institutes/grid.8591.5
135 schema:familyName Karch
136 schema:givenName François
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343043402.10
138 rdf:type schema:Person
139 sg:person.01344047055.75 schema:affiliation https://www.grid.ac/institutes/grid.8591.5
140 schema:familyName Cléard
141 schema:givenName Fabienne
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344047055.75
143 rdf:type schema:Person
144 sg:person.0666556155.32 schema:affiliation https://www.grid.ac/institutes/grid.8591.5
145 schema:familyName Maeda
146 schema:givenName Robert K
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666556155.32
148 rdf:type schema:Person
149 sg:person.0774232717.13 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
150 schema:familyName Moshkin
151 schema:givenName Yuri
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774232717.13
153 rdf:type schema:Person
154 sg:pub.10.1007/s000180050125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050489380
155 https://doi.org/10.1007/s000180050125
156 rdf:type schema:CreativeWork
157 sg:pub.10.1038/276565a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009007731
158 https://doi.org/10.1038/276565a0
159 rdf:type schema:CreativeWork
160 sg:pub.10.1038/74487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036546793
161 https://doi.org/10.1038/74487
162 rdf:type schema:CreativeWork
163 sg:pub.10.1038/85871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044489600
164 https://doi.org/10.1038/85871
165 rdf:type schema:CreativeWork
166 https://app.dimensions.ai/details/publication/pub.1074478941 schema:CreativeWork
167 https://app.dimensions.ai/details/publication/pub.1074543945 schema:CreativeWork
168 https://app.dimensions.ai/details/publication/pub.1074581517 schema:CreativeWork
169 https://app.dimensions.ai/details/publication/pub.1074687943 schema:CreativeWork
170 https://app.dimensions.ai/details/publication/pub.1082526099 schema:CreativeWork
171 https://app.dimensions.ai/details/publication/pub.1082988316 schema:CreativeWork
172 https://app.dimensions.ai/details/publication/pub.1083095162 schema:CreativeWork
173 https://app.dimensions.ai/details/publication/pub.1083271393 schema:CreativeWork
174 https://doi.org/10.1002/j.1460-2075.1989.tb08408.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079051393
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1002/j.1460-2075.1990.tb07439.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1077953510
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1002/j.1460-2075.1990.tb07876.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1078571624
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1002/j.1460-2075.1993.tb05750.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082784708
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.ydbio.2005.08.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008123566
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/s0092-8674(00)81546-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035294751
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/s1097-2765(00)00101-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004934399
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/s1097-2765(01)00377-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028548910
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1073/pnas.92.18.8398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027632558
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1073/pnas.93.22.12418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036456426
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1101/gad.10.24.3195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009273629
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1101/gad.10.24.3202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031200637
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1101/gad.269503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051624170
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1126/science.291.5503.493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007454261
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1126/science.291.5503.495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025624690
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1128/mcb.23.5.1498-1508.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046721823
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1128/mcb.25.9.3682-3689.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038001294
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1242/dev.02323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053379290
209 rdf:type schema:CreativeWork
210 https://www.grid.ac/institutes/grid.5645.2 schema:alternateName Erasmus University Medical Center
211 schema:name Department of Biochemistry, Erasmus University Medical Centre, Dr. Molewaterplein 50, 3015 Rotterdam, The Netherlands.
212 rdf:type schema:Organization
213 https://www.grid.ac/institutes/grid.8591.5 schema:alternateName University of Geneva
214 schema:name Department of Zoology and Animal Biology and National Research Center Frontiers in Genetics, University of Geneva, 30 quai E. Ansermet, 1211 Geneva-4, Switzerland.
215 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...