A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-06-04

AUTHORS

Alex Clop, Fabienne Marcq, Haruko Takeda, Dimitri Pirottin, Xavier Tordoir, Bernard Bibé, Jacques Bouix, Florian Caiment, Jean-Michel Elsen, Francis Eychenne, Catherine Larzul, Elisabeth Laville, Françoise Meish, Dragan Milenkovic, James Tobin, Carole Charlier, Michel Georges

ABSTRACT

Texel sheep are renowned for their exceptional meatiness. To identify the genes underlying this economically important feature, we performed a whole-genome scan in a Romanov × Texel F2 population. We mapped a quantitative trait locus with a major effect on muscle mass to chromosome 2 and subsequently fine-mapped it to a chromosome interval encompassing the myostatin (GDF8) gene. We herein demonstrate that the GDF8 allele of Texel sheep is characterized by a G to A transition in the 3′ UTR that creates a target site for mir1 and mir206, microRNAs (miRNAs) that are highly expressed in skeletal muscle. This causes translational inhibition of the myostatin gene and hence contributes to the muscular hypertrophy of Texel sheep. Analysis of SNP databases for humans and mice demonstrates that mutations creating or destroying putative miRNA target sites are abundant and might be important effectors of phenotypic variation. More... »

PAGES

813-818

Journal

TITLE

Nature Genetics

ISSUE

7

VOLUME

38

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1810

DOI

http://dx.doi.org/10.1038/ng1810

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013209642

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16751773


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