A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-06-04

AUTHORS

Alex Clop, Fabienne Marcq, Haruko Takeda, Dimitri Pirottin, Xavier Tordoir, Bernard Bibé, Jacques Bouix, Florian Caiment, Jean-Michel Elsen, Francis Eychenne, Catherine Larzul, Elisabeth Laville, Françoise Meish, Dragan Milenkovic, James Tobin, Carole Charlier, Michel Georges

ABSTRACT

Texel sheep are renowned for their exceptional meatiness. To identify the genes underlying this economically important feature, we performed a whole-genome scan in a Romanov × Texel F2 population. We mapped a quantitative trait locus with a major effect on muscle mass to chromosome 2 and subsequently fine-mapped it to a chromosome interval encompassing the myostatin (GDF8) gene. We herein demonstrate that the GDF8 allele of Texel sheep is characterized by a G to A transition in the 3′ UTR that creates a target site for mir1 and mir206, microRNAs (miRNAs) that are highly expressed in skeletal muscle. This causes translational inhibition of the myostatin gene and hence contributes to the muscular hypertrophy of Texel sheep. Analysis of SNP databases for humans and mice demonstrates that mutations creating or destroying putative miRNA target sites are abundant and might be important effectors of phenotypic variation. More... »

PAGES

813-818

Journal

TITLE

Nature Genetics

ISSUE

7

VOLUME

38

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1810

DOI

http://dx.doi.org/10.1038/ng1810

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013209642

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16751773


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertrophy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MicroRNAs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myostatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quantitative Trait Loci", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sheep", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clop", 
        "givenName": "Alex", 
        "id": "sg:person.01367315062.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367315062.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marcq", 
        "givenName": "Fabienne", 
        "id": "sg:person.0606525064.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606525064.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeda", 
        "givenName": "Haruko", 
        "id": "sg:person.01022652137.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022652137.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pirottin", 
        "givenName": "Dimitri", 
        "id": "sg:person.01205270411.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205270411.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tordoir", 
        "givenName": "Xavier", 
        "id": "sg:person.01262632164.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262632164.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut National de la Recherche Agronomique\u2013Station d'Am\u00e9lioration G\u00e9n\u00e9tique des Animaux (INRA-SAGA), BP 52627, 31326, Castanet-Tolosan, CEDEX, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institut National de la Recherche Agronomique\u2013Station d'Am\u00e9lioration G\u00e9n\u00e9tique des Animaux (INRA-SAGA), BP 52627, 31326, Castanet-Tolosan, CEDEX, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bib\u00e9", 
        "givenName": "Bernard", 
        "id": "sg:person.0105410267.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0105410267.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut National de la Recherche Agronomique\u2013Station d'Am\u00e9lioration G\u00e9n\u00e9tique des Animaux (INRA-SAGA), BP 52627, 31326, Castanet-Tolosan, CEDEX, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institut National de la Recherche Agronomique\u2013Station d'Am\u00e9lioration G\u00e9n\u00e9tique des Animaux (INRA-SAGA), BP 52627, 31326, Castanet-Tolosan, CEDEX, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouix", 
        "givenName": "Jacques", 
        "id": "sg:person.01151362254.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151362254.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caiment", 
        "givenName": "Florian", 
        "id": "sg:person.01230614734.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230614734.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut National de la Recherche Agronomique\u2013Station d'Am\u00e9lioration G\u00e9n\u00e9tique des Animaux (INRA-SAGA), BP 52627, 31326, Castanet-Tolosan, CEDEX, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institut National de la Recherche Agronomique\u2013Station d'Am\u00e9lioration G\u00e9n\u00e9tique des Animaux (INRA-SAGA), BP 52627, 31326, Castanet-Tolosan, CEDEX, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elsen", 
        "givenName": "Jean-Michel", 
        "id": "sg:person.0711725652.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711725652.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut National de la Recherche Agronomique\u2013Station d'Am\u00e9lioration G\u00e9n\u00e9tique des Animaux (INRA-SAGA), BP 52627, 31326, Castanet-Tolosan, CEDEX, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institut National de la Recherche Agronomique\u2013Station d'Am\u00e9lioration G\u00e9n\u00e9tique des Animaux (INRA-SAGA), BP 52627, 31326, Castanet-Tolosan, CEDEX, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eychenne", 
        "givenName": "Francis", 
        "id": "sg:person.01066145606.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066145606.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut National de la Recherche Agronomique\u2013Station d'Am\u00e9lioration G\u00e9n\u00e9tique des Animaux (INRA-SAGA), BP 52627, 31326, Castanet-Tolosan, CEDEX, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institut National de la Recherche Agronomique\u2013Station d'Am\u00e9lioration G\u00e9n\u00e9tique des Animaux (INRA-SAGA), BP 52627, 31326, Castanet-Tolosan, CEDEX, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larzul", 
        "givenName": "Catherine", 
        "id": "sg:person.01161472736.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161472736.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Station de Recherches sur la Viande, INRA, Theix, 63122, Saint-gen\u00e8s-Champanelle, France", 
          "id": "http://www.grid.ac/institutes/grid.507621.7", 
          "name": [
            "Station de Recherches sur la Viande, INRA, Theix, 63122, Saint-gen\u00e8s-Champanelle, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laville", 
        "givenName": "Elisabeth", 
        "id": "sg:person.01367354544.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367354544.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meish", 
        "givenName": "Fran\u00e7oise", 
        "id": "sg:person.0630135713.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630135713.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "INRA/Universit\u00e9 de Limoges, Facult\u00e9 des Sciences, 87060, Limoges Cedex, France", 
          "id": "http://www.grid.ac/institutes/grid.9966.0", 
          "name": [
            "INRA/Universit\u00e9 de Limoges, Facult\u00e9 des Sciences, 87060, Limoges Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milenkovic", 
        "givenName": "Dragan", 
        "id": "sg:person.01104764635.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104764635.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular and Metabolic Diseases, Wyeth Research, 87 Cambridge Park Drive, 02140, Cambridge, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Cardiovascular and Metabolic Diseases, Wyeth Research, 87 Cambridge Park Drive, 02140, Cambridge, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tobin", 
        "givenName": "James", 
        "id": "sg:person.0744364313.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744364313.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Charlier", 
        "givenName": "Carole", 
        "id": "sg:person.01077502076.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077502076.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Li\u00e8ge (B43), 20 Boulevard de Colonster, 4000, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Georges", 
        "givenName": "Michel", 
        "id": "sg:person.01052036106.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052036106.26"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature03817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035771095", 
          "https://doi.org/10.1038/nature03817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050742226", 
          "https://doi.org/10.1038/nature03441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/78040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039260538", 
          "https://doi.org/10.1038/78040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019747892", 
          "https://doi.org/10.1038/nrg1328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00818163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032495505", 
          "https://doi.org/10.1007/bf00818163"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-06-04", 
    "datePublishedReg": "2006-06-04", 
    "description": "Texel sheep are renowned for their exceptional meatiness. To identify the genes underlying this economically important feature, we performed a whole-genome scan in a Romanov \u00d7 Texel F2 population. We mapped a quantitative trait locus with a major effect on muscle mass to chromosome 2 and subsequently fine-mapped it to a chromosome interval encompassing the myostatin (GDF8) gene. We herein demonstrate that the GDF8 allele of Texel sheep is characterized by a G to A transition in the 3\u2032 UTR that creates a target site for mir1 and mir206, microRNAs (miRNAs) that are highly expressed in skeletal muscle. This causes translational inhibition of the myostatin gene and hence contributes to the muscular hypertrophy of Texel sheep. Analysis of SNP databases for humans and mice demonstrates that mutations creating or destroying putative miRNA target sites are abundant and might be important effectors of phenotypic variation.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ng1810", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6770556", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "keywords": [
      "myostatin gene", 
      "target site", 
      "putative miRNA target sites", 
      "quantitative trait loci", 
      "miRNA target sites", 
      "microRNA target sites", 
      "whole-genome scan", 
      "Texel sheep", 
      "chromosome intervals", 
      "trait loci", 
      "phenotypic variation", 
      "F2 population", 
      "translational inhibition", 
      "chromosome 2", 
      "SNP database", 
      "genes", 
      "important effectors", 
      "skeletal muscle", 
      "mutations", 
      "MIR1", 
      "major effect", 
      "UTR", 
      "loci", 
      "sites", 
      "microRNAs", 
      "effectors", 
      "miR206", 
      "alleles", 
      "sheep", 
      "muscular hypertrophy", 
      "muscle mass", 
      "inhibition", 
      "humans", 
      "population", 
      "mice", 
      "variation", 
      "muscle", 
      "important features", 
      "analysis", 
      "hypertrophy", 
      "mass", 
      "meatiness", 
      "effect", 
      "database", 
      "transition", 
      "features", 
      "muscularity", 
      "interval", 
      "scans"
    ], 
    "name": "A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep", 
    "pagination": "813-818", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013209642"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng1810"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16751773"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng1810", 
      "https://app.dimensions.ai/details/publication/pub.1013209642"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_420.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ng1810"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng1810'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng1810'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng1810'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng1810'


 

This table displays all metadata directly associated to this object as RDF triples.

312 TRIPLES      21 PREDICATES      93 URIs      80 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng1810 schema:about N0ca871256ec64fbe8a8ea698c8e8fe91
2 N0f0c001e68a4429b954bb2e26508c08e
3 N42e9ef5861e1420abb8be18ad0f405ee
4 N6876fc45df19401793393c2e60151a1a
5 N7918c547514d42c8b19328440c97ced2
6 N7b4e07fef1ab4dc184bfd55f15623e93
7 N83477a34c968443c8cfe65a65da12645
8 N8b3f5b8d683e470cb2bcb71f9859c707
9 Nba3226ebb7e64d10b718bbbe5cf55dfd
10 Nbfeb4d11d5f748c0b51144c63207979f
11 Nc09ea414f7fd4c09ae4086e691552ba6
12 Nd2762d6eefc34555b9244efc362f6412
13 Nd3485499e6ab4fb89dcc8863c7d4cdbd
14 Ne6dd6ffa730543f8bb4e9831dc89dcb0
15 anzsrc-for:06
16 anzsrc-for:0604
17 schema:author Nba2b5fdb1fff4cd5a576dd13cc84ae61
18 schema:citation sg:pub.10.1007/bf00818163
19 sg:pub.10.1038/78040
20 sg:pub.10.1038/nature03441
21 sg:pub.10.1038/nature03817
22 sg:pub.10.1038/nrg1328
23 schema:datePublished 2006-06-04
24 schema:datePublishedReg 2006-06-04
25 schema:description Texel sheep are renowned for their exceptional meatiness. To identify the genes underlying this economically important feature, we performed a whole-genome scan in a Romanov × Texel F2 population. We mapped a quantitative trait locus with a major effect on muscle mass to chromosome 2 and subsequently fine-mapped it to a chromosome interval encompassing the myostatin (GDF8) gene. We herein demonstrate that the GDF8 allele of Texel sheep is characterized by a G to A transition in the 3′ UTR that creates a target site for mir1 and mir206, microRNAs (miRNAs) that are highly expressed in skeletal muscle. This causes translational inhibition of the myostatin gene and hence contributes to the muscular hypertrophy of Texel sheep. Analysis of SNP databases for humans and mice demonstrates that mutations creating or destroying putative miRNA target sites are abundant and might be important effectors of phenotypic variation.
26 schema:genre article
27 schema:isAccessibleForFree false
28 schema:isPartOf Ne9389100ba7a4adc9262d77de6092f7f
29 Nf40c689b7b4948bf8f1362ab82d35624
30 sg:journal.1103138
31 schema:keywords F2 population
32 MIR1
33 SNP database
34 Texel sheep
35 UTR
36 alleles
37 analysis
38 chromosome 2
39 chromosome intervals
40 database
41 effect
42 effectors
43 features
44 genes
45 humans
46 hypertrophy
47 important effectors
48 important features
49 inhibition
50 interval
51 loci
52 major effect
53 mass
54 meatiness
55 miR206
56 miRNA target sites
57 mice
58 microRNA target sites
59 microRNAs
60 muscle
61 muscle mass
62 muscular hypertrophy
63 muscularity
64 mutations
65 myostatin gene
66 phenotypic variation
67 population
68 putative miRNA target sites
69 quantitative trait loci
70 scans
71 sheep
72 sites
73 skeletal muscle
74 target site
75 trait loci
76 transition
77 translational inhibition
78 variation
79 whole-genome scan
80 schema:name A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
81 schema:pagination 813-818
82 schema:productId N770f3a71d3844b31beef472f44ab26fc
83 Nd16422875af54591b7d6bc0cbd607b48
84 Nf56a135cfbcc44b0a60f665ac5d67bf5
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013209642
86 https://doi.org/10.1038/ng1810
87 schema:sdDatePublished 2022-09-02T15:51
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher N55efb17223c643faa64c30494dc17753
90 schema:url https://doi.org/10.1038/ng1810
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N0ca871256ec64fbe8a8ea698c8e8fe91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Humans
96 rdf:type schema:DefinedTerm
97 N0f0c001e68a4429b954bb2e26508c08e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Polymorphism, Single Nucleotide
99 rdf:type schema:DefinedTerm
100 N1ca80de3d16945c3a034b408bbff72af rdf:first sg:person.01230614734.17
101 rdf:rest N29d3005a1a4c4500a50a98204b2d0c72
102 N23c6384c6f8f4837a347805522bcbec9 rdf:first sg:person.0744364313.54
103 rdf:rest Nc6794dc6869e4a5b9dc87ff234e60ed6
104 N29d3005a1a4c4500a50a98204b2d0c72 rdf:first sg:person.0711725652.68
105 rdf:rest Na7a8918368e544c68bad05cf259349be
106 N3e95ec74343d4a2ea468d33e8e27f598 rdf:first sg:person.01161472736.42
107 rdf:rest N6b9cf14d84c04311b446f95b38777701
108 N42e9ef5861e1420abb8be18ad0f405ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Binding Sites
110 rdf:type schema:DefinedTerm
111 N4adf7b1b290243da87dd0e4e113d3538 rdf:first sg:person.01262632164.46
112 rdf:rest N9563cd17a6a84ec7b1cb9d58af6060d2
113 N55efb17223c643faa64c30494dc17753 schema:name Springer Nature - SN SciGraph project
114 rdf:type schema:Organization
115 N55f22c1c1be8480ba8d52d80b59298c5 rdf:first sg:person.0606525064.25
116 rdf:rest N77a601811a9a4c32a2b3c70598cd4689
117 N6876fc45df19401793393c2e60151a1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Transforming Growth Factor beta
119 rdf:type schema:DefinedTerm
120 N6b9cf14d84c04311b446f95b38777701 rdf:first sg:person.01367354544.13
121 rdf:rest Ne588448e3d6e45b5b05fadab5600952a
122 N770f3a71d3844b31beef472f44ab26fc schema:name dimensions_id
123 schema:value pub.1013209642
124 rdf:type schema:PropertyValue
125 N77a601811a9a4c32a2b3c70598cd4689 rdf:first sg:person.01022652137.51
126 rdf:rest Na4899abdcf7d480986aaa75f8c9b5330
127 N7918c547514d42c8b19328440c97ced2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Hypertrophy
129 rdf:type schema:DefinedTerm
130 N7b4e07fef1ab4dc184bfd55f15623e93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Chromosome Mapping
132 rdf:type schema:DefinedTerm
133 N83477a34c968443c8cfe65a65da12645 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name MicroRNAs
135 rdf:type schema:DefinedTerm
136 N8b3f5b8d683e470cb2bcb71f9859c707 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Sheep
138 rdf:type schema:DefinedTerm
139 N9563cd17a6a84ec7b1cb9d58af6060d2 rdf:first sg:person.0105410267.70
140 rdf:rest Nef67bd71873b43979082153136ccca64
141 Na4899abdcf7d480986aaa75f8c9b5330 rdf:first sg:person.01205270411.37
142 rdf:rest N4adf7b1b290243da87dd0e4e113d3538
143 Na7a8918368e544c68bad05cf259349be rdf:first sg:person.01066145606.84
144 rdf:rest N3e95ec74343d4a2ea468d33e8e27f598
145 Nba2b5fdb1fff4cd5a576dd13cc84ae61 rdf:first sg:person.01367315062.09
146 rdf:rest N55f22c1c1be8480ba8d52d80b59298c5
147 Nba3226ebb7e64d10b718bbbe5cf55dfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Mutation
149 rdf:type schema:DefinedTerm
150 Nbd219485b4574964a06c44a825cf3163 rdf:first sg:person.01052036106.26
151 rdf:rest rdf:nil
152 Nbfeb4d11d5f748c0b51144c63207979f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Muscle, Skeletal
154 rdf:type schema:DefinedTerm
155 Nc09ea414f7fd4c09ae4086e691552ba6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Myostatin
157 rdf:type schema:DefinedTerm
158 Nc6794dc6869e4a5b9dc87ff234e60ed6 rdf:first sg:person.01077502076.34
159 rdf:rest Nbd219485b4574964a06c44a825cf3163
160 Nc745e0a179604f41b426f4e5f51d4b6b rdf:first sg:person.01104764635.09
161 rdf:rest N23c6384c6f8f4837a347805522bcbec9
162 Nd16422875af54591b7d6bc0cbd607b48 schema:name doi
163 schema:value 10.1038/ng1810
164 rdf:type schema:PropertyValue
165 Nd2762d6eefc34555b9244efc362f6412 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Quantitative Trait Loci
167 rdf:type schema:DefinedTerm
168 Nd3485499e6ab4fb89dcc8863c7d4cdbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Mice
170 rdf:type schema:DefinedTerm
171 Ne588448e3d6e45b5b05fadab5600952a rdf:first sg:person.0630135713.97
172 rdf:rest Nc745e0a179604f41b426f4e5f51d4b6b
173 Ne6dd6ffa730543f8bb4e9831dc89dcb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Animals
175 rdf:type schema:DefinedTerm
176 Ne9389100ba7a4adc9262d77de6092f7f schema:volumeNumber 38
177 rdf:type schema:PublicationVolume
178 Nef67bd71873b43979082153136ccca64 rdf:first sg:person.01151362254.26
179 rdf:rest N1ca80de3d16945c3a034b408bbff72af
180 Nf40c689b7b4948bf8f1362ab82d35624 schema:issueNumber 7
181 rdf:type schema:PublicationIssue
182 Nf56a135cfbcc44b0a60f665ac5d67bf5 schema:name pubmed_id
183 schema:value 16751773
184 rdf:type schema:PropertyValue
185 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
186 schema:name Biological Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
189 schema:name Genetics
190 rdf:type schema:DefinedTerm
191 sg:grant.6770556 http://pending.schema.org/fundedItem sg:pub.10.1038/ng1810
192 rdf:type schema:MonetaryGrant
193 sg:journal.1103138 schema:issn 1061-4036
194 1546-1718
195 schema:name Nature Genetics
196 schema:publisher Springer Nature
197 rdf:type schema:Periodical
198 sg:person.01022652137.51 schema:affiliation grid-institutes:grid.4861.b
199 schema:familyName Takeda
200 schema:givenName Haruko
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022652137.51
202 rdf:type schema:Person
203 sg:person.01052036106.26 schema:affiliation grid-institutes:grid.4861.b
204 schema:familyName Georges
205 schema:givenName Michel
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052036106.26
207 rdf:type schema:Person
208 sg:person.0105410267.70 schema:affiliation grid-institutes:None
209 schema:familyName Bibé
210 schema:givenName Bernard
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0105410267.70
212 rdf:type schema:Person
213 sg:person.01066145606.84 schema:affiliation grid-institutes:None
214 schema:familyName Eychenne
215 schema:givenName Francis
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066145606.84
217 rdf:type schema:Person
218 sg:person.01077502076.34 schema:affiliation grid-institutes:grid.4861.b
219 schema:familyName Charlier
220 schema:givenName Carole
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077502076.34
222 rdf:type schema:Person
223 sg:person.01104764635.09 schema:affiliation grid-institutes:grid.9966.0
224 schema:familyName Milenkovic
225 schema:givenName Dragan
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104764635.09
227 rdf:type schema:Person
228 sg:person.01151362254.26 schema:affiliation grid-institutes:None
229 schema:familyName Bouix
230 schema:givenName Jacques
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151362254.26
232 rdf:type schema:Person
233 sg:person.01161472736.42 schema:affiliation grid-institutes:None
234 schema:familyName Larzul
235 schema:givenName Catherine
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161472736.42
237 rdf:type schema:Person
238 sg:person.01205270411.37 schema:affiliation grid-institutes:grid.4861.b
239 schema:familyName Pirottin
240 schema:givenName Dimitri
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205270411.37
242 rdf:type schema:Person
243 sg:person.01230614734.17 schema:affiliation grid-institutes:grid.4861.b
244 schema:familyName Caiment
245 schema:givenName Florian
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230614734.17
247 rdf:type schema:Person
248 sg:person.01262632164.46 schema:affiliation grid-institutes:grid.4861.b
249 schema:familyName Tordoir
250 schema:givenName Xavier
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262632164.46
252 rdf:type schema:Person
253 sg:person.01367315062.09 schema:affiliation grid-institutes:grid.4861.b
254 schema:familyName Clop
255 schema:givenName Alex
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367315062.09
257 rdf:type schema:Person
258 sg:person.01367354544.13 schema:affiliation grid-institutes:grid.507621.7
259 schema:familyName Laville
260 schema:givenName Elisabeth
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367354544.13
262 rdf:type schema:Person
263 sg:person.0606525064.25 schema:affiliation grid-institutes:grid.4861.b
264 schema:familyName Marcq
265 schema:givenName Fabienne
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606525064.25
267 rdf:type schema:Person
268 sg:person.0630135713.97 schema:affiliation grid-institutes:grid.4861.b
269 schema:familyName Meish
270 schema:givenName Françoise
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630135713.97
272 rdf:type schema:Person
273 sg:person.0711725652.68 schema:affiliation grid-institutes:None
274 schema:familyName Elsen
275 schema:givenName Jean-Michel
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711725652.68
277 rdf:type schema:Person
278 sg:person.0744364313.54 schema:affiliation grid-institutes:grid.410513.2
279 schema:familyName Tobin
280 schema:givenName James
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744364313.54
282 rdf:type schema:Person
283 sg:pub.10.1007/bf00818163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032495505
284 https://doi.org/10.1007/bf00818163
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/78040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039260538
287 https://doi.org/10.1038/78040
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/nature03441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050742226
290 https://doi.org/10.1038/nature03441
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/nature03817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035771095
293 https://doi.org/10.1038/nature03817
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/nrg1328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019747892
296 https://doi.org/10.1038/nrg1328
297 rdf:type schema:CreativeWork
298 grid-institutes:None schema:alternateName Institut National de la Recherche Agronomique–Station d'Amélioration Génétique des Animaux (INRA-SAGA), BP 52627, 31326, Castanet-Tolosan, CEDEX, France
299 schema:name Institut National de la Recherche Agronomique–Station d'Amélioration Génétique des Animaux (INRA-SAGA), BP 52627, 31326, Castanet-Tolosan, CEDEX, France
300 rdf:type schema:Organization
301 grid-institutes:grid.410513.2 schema:alternateName Cardiovascular and Metabolic Diseases, Wyeth Research, 87 Cambridge Park Drive, 02140, Cambridge, Massachusetts, USA
302 schema:name Cardiovascular and Metabolic Diseases, Wyeth Research, 87 Cambridge Park Drive, 02140, Cambridge, Massachusetts, USA
303 rdf:type schema:Organization
304 grid-institutes:grid.4861.b schema:alternateName Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Liège (B43), 20 Boulevard de Colonster, 4000, Liège, Belgium
305 schema:name Department of Animal Production, Unit of Animal Genomics, Faculty of Veterinary Medicine & Centre for Biomedical Integrative Genoproteomics, University of Liège (B43), 20 Boulevard de Colonster, 4000, Liège, Belgium
306 rdf:type schema:Organization
307 grid-institutes:grid.507621.7 schema:alternateName Station de Recherches sur la Viande, INRA, Theix, 63122, Saint-genès-Champanelle, France
308 schema:name Station de Recherches sur la Viande, INRA, Theix, 63122, Saint-genès-Champanelle, France
309 rdf:type schema:Organization
310 grid-institutes:grid.9966.0 schema:alternateName INRA/Université de Limoges, Faculté des Sciences, 87060, Limoges Cedex, France
311 schema:name INRA/Université de Limoges, Faculté des Sciences, 87060, Limoges Cedex, France
312 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...