A common variant associated with prostate cancer in European and African populations View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-05-07

AUTHORS

Laufey T Amundadottir, Patrick Sulem, Julius Gudmundsson, Agnar Helgason, Adam Baker, Bjarni A Agnarsson, Asgeir Sigurdsson, Kristrun R Benediktsdottir, Jean-Baptiste Cazier, Jesus Sainz, Margret Jakobsdottir, Jelena Kostic, Droplaug N Magnusdottir, Shyamali Ghosh, Kari Agnarsson, Birgitta Birgisdottir, Louise Le Roux, Adalheidur Olafsdottir, Thorarinn Blondal, Margret Andresdottir, Olafia Svandis Gretarsdottir, Jon T Bergthorsson, Daniel Gudbjartsson, Arnaldur Gylfason, Gudmar Thorleifsson, Andrei Manolescu, Kristleifur Kristjansson, Gudmundur Geirsson, Helgi Isaksson, Julie Douglas, Jan-Erik Johansson, Katarina Bälter, Fredrik Wiklund, James E Montie, Xiaoying Yu, Brian K Suarez, Carole Ober, Kathleen A Cooney, Henrik Gronberg, William J Catalona, Gudmundur V Einarsson, Rosa B Barkardottir, Jeffrey R Gulcher, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson

ABSTRACT

With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele −8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 × 10−11). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of ∼8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry. More... »

PAGES

652-658

Journal

TITLE

Nature Genetics

ISSUE

6

VOLUME

38

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1808

DOI

http://dx.doi.org/10.1038/ng1808

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008387561

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16682969


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