Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling View Full Text


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Article Info

DATE

2006-02-19

AUTHORS

Tae Joo Park, Saori L Haigo, John B Wallingford

ABSTRACT

The vertebrate planar cell polarity (PCP) pathway has previously been found to control polarized cell behaviors rather than cell fate. We report here that disruption of Xenopus laevis orthologs of the Drosophila melanogaster PCP effectors inturned (in) or fuzzy (fy) affected not only PCP-dependent convergent extension but also elicited embryonic phenotypes consistent with defective Hedgehog signaling. These defects in Hedgehog signaling resulted from a broad requirement for Inturned and Fuzzy in ciliogenesis. We show that these proteins govern apical actin assembly and thus control the orientation, but not assembly, of ciliary microtubules. Finally, accumulation of Dishevelled and Inturned near the basal apparatus of cilia suggests that these proteins function in a common pathway with core PCP components to regulate ciliogenesis. Together, these data highlight the interrelationships between cell polarity, cellular morphogenesis, signal transduction and cell fate specification. More... »

PAGES

303-311

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  • 2005-09-18. Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates in NATURE GENETICS
  • 2002-09-17. XHRT-1, a hairy and Enhancer of split related gene with expression in floor plate and hypochord during early Xenopus embryogenesis in DEVELOPMENT GENES AND EVOLUTION
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    http://scigraph.springernature.com/pub.10.1038/ng1753

    DOI

    http://dx.doi.org/10.1038/ng1753

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012389040

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16493421


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