Evidence for an instructive mechanism of de novo methylation in cancer cells View Full Text


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Article Info

DATE

2006-01-24

AUTHORS

Ilana Keshet, Yeshayahu Schlesinger, Shlomit Farkash, Eyal Rand, Merav Hecht, Eran Segal, Eli Pikarski, Richard A Young, Alain Niveleau, Howard Cedar, Itamar Simon

ABSTRACT

DNA methylation has a role in the regulation of gene expression during normal mammalian development but can also mediate epigenetic silencing of CpG island genes in cancer and other diseases. Many individual genes (including tumor suppressors) have been shown to undergo de novo methylation in specific tumor types, but the biological logic inherent in this process is not understood. To decipher this mechanism, we have adopted a new approach for detecting CpG island DNA methylation that can be used together with microarray technology. Genome-wide analysis by this technique demonstrated that tumor-specific methylated genes belong to distinct functional categories, have common sequence motifs in their promoters and are found in clusters on chromosomes. In addition, many are already repressed in normal cells. These results are consistent with the hypothesis that cancer-related de novo methylation may come about through an instructive mechanism. More... »

PAGES

149-153

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1719

DOI

http://dx.doi.org/10.1038/ng1719

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017063597

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16444255


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