Dosage compensation of the active X chromosome in mammals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-01

AUTHORS

Di Kim Nguyen, Christine M Disteche

ABSTRACT

Monosomy of the X chromosome owing to divergence between the sex chromosomes leads to dosage compensation mechanisms to restore balanced expression between the X and the autosomes. In Drosophila melanogaster, upregulation of the male X leads to dosage compensation. It has been hypothesized that mammals likewise upregulate their active X chromosome. Together with X inactivation, this mechanism would maintain balanced expression between the X chromosome and autosomes and between the sexes. Here, we show that doubling of the global expression level of the X chromosome leads to dosage compensation in somatic tissues from several mammalian species. X-linked genes are highly expressed in brain tissues, consistent with a role in cognitive functions. Furthermore, the X chromosome is expressed but not upregulated in spermatids and secondary oocytes, preserving balanced expression of the genome in these haploid cells. Upon fertilization, upregulation of the active X must occur to achieve the observed dosage compensation in early embryos. More... »

PAGES

47-53

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1705

DOI

http://dx.doi.org/10.1038/ng1705

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023508625

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16341221


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng1705'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng1705'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng1705'


 

This table displays all metadata directly associated to this object as RDF triples.

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