Ontology type: schema:ScholarlyArticle
2006-01
AUTHORSDi Kim Nguyen, Christine M Disteche
ABSTRACTMonosomy of the X chromosome owing to divergence between the sex chromosomes leads to dosage compensation mechanisms to restore balanced expression between the X and the autosomes. In Drosophila melanogaster, upregulation of the male X leads to dosage compensation. It has been hypothesized that mammals likewise upregulate their active X chromosome. Together with X inactivation, this mechanism would maintain balanced expression between the X chromosome and autosomes and between the sexes. Here, we show that doubling of the global expression level of the X chromosome leads to dosage compensation in somatic tissues from several mammalian species. X-linked genes are highly expressed in brain tissues, consistent with a role in cognitive functions. Furthermore, the X chromosome is expressed but not upregulated in spermatids and secondary oocytes, preserving balanced expression of the genome in these haploid cells. Upon fertilization, upregulation of the active X must occur to achieve the observed dosage compensation in early embryos. More... »
PAGES47-53
http://scigraph.springernature.com/pub.10.1038/ng1705
DOIhttp://dx.doi.org/10.1038/ng1705
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1023508625
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/16341221
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dosage Compensation, Genetic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drosophila",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Embryonic Development",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation, Developmental",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mammals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Spermatids",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Up-Regulation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "X Chromosome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "X Chromosome Inactivation",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Washington",
"id": "https://www.grid.ac/institutes/grid.34477.33",
"name": [
"Department of Pathology, University of Washington, Seattle, Washington 98195, USA."
],
"type": "Organization"
},
"familyName": "Nguyen",
"givenName": "Di Kim",
"id": "sg:person.01261143276.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261143276.37"
],
"type": "Person"
},
{
"familyName": "Disteche",
"givenName": "Christine M",
"id": "sg:person.01071102663.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071102663.03"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1073/pnas.1635054100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000127644"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-437x(03)00016-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000407342"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0045-6039(72)90039-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002099147"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0045-6039(72)90039-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002099147"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/ddh241",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002197405"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0400782101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002732260"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ydbio.2004.05.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003795125"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.devcel.2004.05.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005766708"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/jbiol30",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006105526",
"https://doi.org/10.1186/jbiol30"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.221465998",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006830883"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03479",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007477207",
"https://doi.org/10.1038/nature03479"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03479",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007477207",
"https://doi.org/10.1038/nature03479"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ydbio.2004.01.027",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009061192"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/jmg.2004.025353",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009873137"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0308725100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010950379"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/bies.20082",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011583430"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/physiolgenomics.00049.2003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013381732"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg1501",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013383518",
"https://doi.org/10.1038/nrg1501"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg1501",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013383518",
"https://doi.org/10.1038/nrg1501"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1484",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014678206",
"https://doi.org/10.1038/ng1484"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1484",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014678206",
"https://doi.org/10.1038/ng1484"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/gb-2004-5-9-r69",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015328328",
"https://doi.org/10.1186/gb-2004-5-9-r69"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0168-9525(01)02446-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015592620"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/dbio.1995.1252",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017521414"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-3-642-88178-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017975083",
"https://doi.org/10.1007/978-3-642-88178-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-3-642-88178-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017975083",
"https://doi.org/10.1007/978-3-642-88178-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4757-0659-8_3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018497554",
"https://doi.org/10.1007/978-1-4757-0659-8_3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/dbio.1996.0305",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019071180"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature02222",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019461459",
"https://doi.org/10.1038/nature02222"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature02222",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019461459",
"https://doi.org/10.1038/nature02222"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00285153",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020498754",
"https://doi.org/10.1007/bf00285153"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/ddh154",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022587008"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1098/rstb.2000.0717",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028099776"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/1050-3862(92)90051-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028578678"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/1050-3862(92)90051-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028578678"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1022935927763",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028969859",
"https://doi.org/10.1023/a:1022935927763"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1095/biolreprod.103.023796",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029185052"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.94.17.9244",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030291699"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gr.2161804",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032511511"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.febslet.2005.03.050",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033243480"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1534-5807(03)00404-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036029081"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0406325101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038120063"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1091/mbc.e03-10-0762",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041187553"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.012025199",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044815609"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/11.26.3249",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045198781"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/ddg217",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045406714"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1095/biolreprod59.1.84",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045791248"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1095/biolreprod59.1.84",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045791248"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1092727",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046251253"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/190372a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048297848",
"https://doi.org/10.1038/190372a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1368",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048971359",
"https://doi.org/10.1038/ng1368"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1368",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048971359",
"https://doi.org/10.1038/ng1368"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000071572",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049637131"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/299838a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050729806",
"https://doi.org/10.1038/299838a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tig.2005.02.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050908692"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-9822(02)00448-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051005894"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1092674",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062449210"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082277044",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082589168",
"type": "CreativeWork"
}
],
"datePublished": "2006-01",
"datePublishedReg": "2006-01-01",
"description": "Monosomy of the X chromosome owing to divergence between the sex chromosomes leads to dosage compensation mechanisms to restore balanced expression between the X and the autosomes. In Drosophila melanogaster, upregulation of the male X leads to dosage compensation. It has been hypothesized that mammals likewise upregulate their active X chromosome. Together with X inactivation, this mechanism would maintain balanced expression between the X chromosome and autosomes and between the sexes. Here, we show that doubling of the global expression level of the X chromosome leads to dosage compensation in somatic tissues from several mammalian species. X-linked genes are highly expressed in brain tissues, consistent with a role in cognitive functions. Furthermore, the X chromosome is expressed but not upregulated in spermatids and secondary oocytes, preserving balanced expression of the genome in these haploid cells. Upon fertilization, upregulation of the active X must occur to achieve the observed dosage compensation in early embryos.",
"genre": "research_article",
"id": "sg:pub.10.1038/ng1705",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1103138",
"issn": [
"1061-4036",
"1546-1718"
],
"name": "Nature Genetics",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "38"
}
],
"name": "Dosage compensation of the active X chromosome in mammals",
"pagination": "47-53",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"70009768e8c28eedcf77ddeae620c31a64c771b0e3f5895c6afd9d15a2d78d1f"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"16341221"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9216904"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/ng1705"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1023508625"
]
}
],
"sameAs": [
"https://doi.org/10.1038/ng1705",
"https://app.dimensions.ai/details/publication/pub.1023508625"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T12:11",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53981_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/ng/journal/v38/n1/full/ng1705.html"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng1705'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng1705'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng1705'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng1705'
This table displays all metadata directly associated to this object as RDF triples.
300 TRIPLES
21 PREDICATES
95 URIs
37 LITERALS
25 BLANK NODES