Common deletions and SNPs are in linkage disequilibrium in the human genome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-01

AUTHORS

David A Hinds, Andrew P Kloek, Michael Jen, Xiyin Chen, Kelly A Frazer

ABSTRACT

Humans show great variation in phenotypic traits such as height, eye color and susceptibility to disease. Genomic DNA sequence differences among individuals are responsible for the inherited components of these complex traits. Reports suggest that intermediate and large-scale DNA copy number and structural variations are prevalent enough to be an important source of genetic variation between individuals. Because association studies to identify genomic loci associated with particular phenotypic traits have focused primarily on genotyping SNPs, it is important to determine whether common structural polymorphisms are in linkage disequilibrium with common SNPs, and thus can be assessed indirectly in SNP-based studies. Here we examine 100 deletion polymorphisms ranging from 70 bp to 7 kb. We show that common deletions and SNPs ascertained with similar criteria have essentially the same distribution of linkage disequilibrium with surrounding SNPs, indicating that these polymorphisms may share evolutionary history and that most deletion polymorphisms are effectively assayed by proxy in SNP-based association studies. More... »

PAGES

82-85

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1695

DOI

http://dx.doi.org/10.1038/ng1695

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032451322

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16327809


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