The t complex–encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-09

AUTHORS

Hermann Bauer, Jürgen Willert, Birgit Koschorz, Bernhard G Herrmann

ABSTRACT

Transmission ratio distortion in the mouse is caused by several t-complex distorters (Tcds) acting in trans on the t-complex responder (Tcr). Tcds additively affect the flagellar movement of all spermatozoa derived from t/+ males; sperm carrying Tcr are rescued, resulting in an advantage for t sperm in fertilization. Here we show that Tagap1, a GTPase-activating protein, can act as a distorter. Tagap1 maps to the Tcd1 interval and has four t loci, which encode altered proteins including a C-terminally truncated form. Overexpression of wild-type Tagap1 in sperm cells phenocopied Tcd function, whereas a loss-of-function Tagap1 allele reduced the transmission rate of the t6 haplotype. The combined data strongly suggest that the t loci of Tagap1 produce Tcd1a. Our results unravel the molecular nature of a Tcd and demonstrate the importance of small G proteins in transmission ratio distortion in the mouse. More... »

PAGES

969-973

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1617

DOI

http://dx.doi.org/10.1038/ng1617

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045487331

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16116428


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