Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-04

AUTHORS

Mario F Fraga, Esteban Ballestar, Ana Villar-Garea, Manuel Boix-Chornet, Jesus Espada, Gunnar Schotta, Tiziana Bonaldi, Claire Haydon, Santiago Ropero, Kevin Petrie, N Gopalakrishna Iyer, Alberto Pérez-Rosado, Enrique Calvo, Juan A Lopez, Amparo Cano, Maria J Calasanz, Dolors Colomer, Miguel Angel Piris, Natalie Ahn, Axel Imhof, Carlos Caldas, Thomas Jenuwein, Manel Esteller

ABSTRACT

CpG island hypermethylation and global genomic hypomethylation are common epigenetic features of cancer cells. Less attention has been focused on histone modifications in cancer cells. We characterized post-translational modifications to histone H4 in a comprehensive panel of normal tissues, cancer cell lines and primary tumors. Using immunodetection, high-performance capillary electrophoresis and mass spectrometry, we found that cancer cells had a loss of monoacetylated and trimethylated forms of histone H4. These changes appeared early and accumulated during the tumorigenic process, as we showed in a mouse model of multistage skin carcinogenesis. The losses occurred predominantly at the acetylated Lys16 and trimethylated Lys20 residues of histone H4 and were associated with the hypomethylation of DNA repetitive sequences, a well-known characteristic of cancer cells. Our data suggest that the global loss of monoacetylation and trimethylation of histone H4 is a common hallmark of human tumor cells. More... »

PAGES

391-400

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1531

DOI

http://dx.doi.org/10.1038/ng1531

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029978023

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15765097


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